Patents by Inventor Lars Kober

Lars Kober has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted aminoquinolones as DGKalpha inhibitors for immune activation
    Patent number: 11998539
    Abstract: The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: November 30, 2022
    Date of Patent: June 4, 2024
    Assignees: BAYER AKTIENGESELLSCHAFT, BAYER PHARMA AKTIENGESELLSCHAFT, DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Norbert Schmees, Lars Wortmann, Dennis Kirchhoff, Thi Thanh Uyen Nguyen, Nicolas Werbeck, Ulf Bömer, Kirstin Petersen, Christina Kober, Christian Lechner, Dirk Kosemund, Rienk Offringa, Mareike Grees, Benjamin Bader
  • CELL CULTURE MEDIUM FOR CULTIVATING CELLS, METHOD FOR CULTIVATING CELLS, AND METHOD FOR EXPRESSING AT LEAST ONE RECOMBINANT PROTEIN IN A CELL CULTURE
    Publication number: 20220298472
    Abstract: Disclosed is a cell culture medium for cultivating cells, containing an iron-citrate-diphosphate complex as an iron source. Also disclosed is a method for cultivating cells, one or more cells being replicated or maintained in the cell culture medium and to a method for expressing at least one recombinant protein in a cell culture, a nucleic acid being introduced into the cell replicated or maintained in the cell culture medium, wherein the nucleic acid causes the production of at least one recombinant protein. The cell culture medium is advantageous in that the iron source contained therein dissolves very efficiently and rapidly in an aqueous solution, can be efficiently imported into the interior of the cells, causes an increased cell viability and an increased product titer during the production of recombinant proteins, and is very inexpensive.
    Type: Application
    Filed: August 14, 2020
    Publication date: September 22, 2022
    Applicant: UGA BIOPHARMA GMBH
    Inventors: Lars KOBER, Sarah HERRMANN
  • Mammalian culture media with polyamine and iron
    Patent number: 8637312
    Abstract: The present invention relates to an improved cell culture additive with a content of polyamines and iron, media containing it and processes for using it for an improved cell growth, cell viability or cellular productivity.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: January 28, 2014
    Assignee: Cellca GmbH
    Inventors: Olaf Krüger, Kerstin Oellers, Lars Kober
  • CULTURE MEDIA ADDITIVE AND PROCESS FOR USING IT
    Publication number: 20100285533
    Abstract: The present invention relates to an improved cell culture additive with a content of polyamines and iron, media containing it and processes for using it for an improved cell growth, cell viability or cellular productivity.
    Type: Application
    Filed: January 7, 2009
    Publication date: November 11, 2010
    Inventors: Olaf Krüger, Kerstin Oellers, Lars Kober