Patent number: 6521606
Abstract: A compound of the general formula I
wherein Y is O or S;
n is 1, 2, 3 or 4;
X represents hydroxamic acid, carboxylic acid, phosphonic acid, acetylthiomethyl group or a mercaptomethyl group;
R1 is
wherein E, when present represents, a bond or optionally substituted methylene or ethylene;
s and t are independently 0, 1, 2 or 3;
A and A′ independently represent a bond, or a saturated or unsaturated, optionally substituted cyclic or heterocyclic hydrocarbon di- or triradical;
Z represents a bond, O, S, C(O), C(O)NR7, NR7C(O) or NR7, wherein R7 is hydrogen, hydroxy, branched or straight, saturated or unsaturated, optionally substituted hydrocarbon radical;
R5 represents a bond, alkane or alkene diradical, one or more ether diradicals (R—O—R′) or amine diradicals (R—N—R′), wherein R and R′ independently represent alkane or alkene diradicals with a C-content from 0 to 3;
R6 represents hydrogen, hydroxy, halogen, cyano, nitro,
Type:
Grant
Filed:
July 6, 2001
Date of Patent:
February 18, 2003
Assignee:
Leo Pharmaceutical Products, Ltd. A/S
Inventors:
Morten Dahl Sørensen, Lars Kristian Albert Blæhr, Mette Knak Christensen