Abstract: The neutralizing prolactin receptor antibody Mat3, and antigen binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation and for the treatment and prevention of antiestrogen-resistant breast cancer. The antibody blocks prolactin receptor-mediated signalling.

Abstract: The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.

Abstract: The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present invention relates to a control method in a system comprising —a server unit having computer means, communication means and a first data base, said first data base including positioning data and a plurality of work orders, wherein said work orders are related to said positioning data; and —a sawing machine having computer means and communication means, and being arranged for sawing trenches in an area; said method comprising the steps of: —transmitting, by said server unit, a first data flow A comprising a first work order to said sawing machine; and —controlling said sawing machine by means of said first work order. Furthermore, the invention also relates to a system thereof.

Abstract: The present invention relates to a saw blade for a sawing machine, said sawing machine (10) being arranged for cutting micro trenches by means of said saw blade (1), wherein said micro trenches are adapted for receiving at least one duct/cable; wherein said saw blade comprises mechanical coding means (2) selected from the group consisting of holes, depressions and protrusions arranged on said saw blade (1); and said holes, depressions and protrusions being coding elements for forming at least one code symbol (4) representing a unique identity (ID) for said saw blade.

Abstract: The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target mesothelin, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract: The present invention relates to a method for preparing a solution of a refolded, recombinantly expressed or chemically synthesized eukaryotic membrane protein in monodisperse form, to methods for preparing a crystalline form of a recombinantly expressed or chemically synthesized membrane protein, to a crystalline form of a recombinantly expressed, or chemically synthesized eukaryotic membrane protein, and to a crystalline form of a complex of a recombinantly expressed or chemically synthesized eukaryotic membrane protein and of an accessory agent.

Abstract: A method and system are provided for optimal routing of calls in an Internet Protocol-based Base Station System (IP-based BSS), whereby a plurality of new messages are introduced on the A-interface. One such message informs the BSS that the Circuit Identity Codes (CICs) included in the message can be connected to the BSS to provide optimal routing of one or more calls. Another such message informs the BSS that the CICs included in the message are to be restored as separate CICs on the A-interface. The provision of such messages overcomes the significant disadvantages of the existing and developing BSS implementations.

Abstract: The present invention relates to a method for preparing a solution of a refolded, recombinantly expressed or chemically synthesized eukaryotic membrane protein in monodisperse form, to methods for preparing a crystalline form of a recombinantly expressed or chemically synthesized membrane protein, to a crystalline form of a recombinantly expressed, or chemically synthesized eukaryotic membrane protein, and to a crystalline form of a complex of a recombinantly expressed or chemically synthesized eukaryotic membrane protein and of an accessory agent.

Abstract: A sliding door operating mechanism for a vehicle to provide access to the vehicle through an opening in a wall thereof, includes at least one sliding door and a reciprocating power mechanism and a transmission mechanism for transmitting movement of power to the door for performing opening, closing and locking movements thereof. A beam structure carries the door, the power mechanism and the transmission mechanism. The beam structure extends across and is accommodated within an upper portion of the opening so as to be slidingly movably driven by the power mechanism between a relatively retracted position within the opening, in which the door is located in a first plane in a closed position confirmed within the opening, and a relatively less retracted position, in which the door is located in a second plane exteriorly of the opening allowing movement of the door along the second plane.

Abstract: The present invention relates to a packet data communication system and is primarily intended for packet data radio communication systems, such as a GSM-system (PLMN) supporting a GPRS-service. A data frame received from a connected second packet data network (Internet) is divided into a sequence of data segments (DS). Speech packets (SPP) with an origin from a connected telecommunication network and the segments (DS) and are transmitted over a packet data link (PL1) to a radio base station (BTS) with priority given to the speech packets (SPP). The data segments (DS) shall be transmitted on a corresponding radio link (RL2) to a designated mobile station (MS). The problem is that during high traffic loads the segments are subjected to long delays and as a result no segments can be transmitted on the corresponding radio link. Giving priority to a first few data segments of the sequence when transmitted over the packet data link (PL1) solves the problem.

Abstract: A sliding door operating mechanism for a vehicle to provide access to the vehicle through an opening in a wall thereof, includes at least one sliding door and reciprocating power means and transmission means for transmitting movement of the power means to the door for performing opening, closing and locking movements thereof. A beam structure carries the door, the power means and the transmission means. The beam structure extends across and is accommodated with an upper portion of the opening so as to be slidingly movably driven by the power means between a relatively retracted position within the opening, in which the door is located in a first plane in a closed position confined within the opening, and a relatively less retracted position, in which the door is located in a second plane exteriorly of the opening allowing movement of the door means along the second plane.

Abstract: A method and system are provided for optimal routing of calls in an Internet Protocol-based Base Station System (IP-based BSS), whereby a plurality of new messages are introduced on the A-interface. One such message informs the BSS that the Circuit Identity Codes (CICs) included in the message can be connected to the BSS to provide optimal routing of one or more calls. Another such message informs the BSS that the CICs included in the message are to be restored as separate CICs on the A-interface. The provision of such messages overcomes the significant disadvantages of the existing and developing BSS implementations.

Abstract: A method and system are provided for configuring a mobile communications network, such as for example, in an IP-based Base Station System, to ensure high availability of network elements especially during catastrophic events.