Abstract: A cover glass is provided that includes a silica based glass ceramic with a thickness between 0.4 mm and 0.85 mm. The glass ceramic has a transmittance of more than 80% from 380 nm to 780 nm and a stress attribute selected from: an overall compressive stress (CS) of at least 250 MPa and at most 1500 MPa, a compressive stress at a depth of 30 ?m (CS30) from one of the two faces of at least 160 MPa and at most 525 MPa, a depth of the compression layer (DoCL) of at least 0.2 times the thickness and less than 0.5 times the thickness, and any combinations thereof. The glass ceramic has at least one silica based crystal phase having in a near-surface layer a unit cell volume of at least 1% by volume larger than that of a core where the crystal phase has minimum stresses.

Abstract: Systems and methods are provided for determining patterns, trends, anomalies, and/or abnormalities in data relating to operation of an insulin delivery pump and user outcomes relating to an insulin delivery pump and determining certain actions and/or operational adjustments to improve the user outcomes, such as blood glucose levels. For example, troubleshooting actions may be recommended upon determining a pattern, trend, abnormality, and/or anomaly in blood glucose levels that is undesirable. In another example, operation of the insulin delivery pump may be adjusted based habits and/or behaviors of the user. For example, insulin delivery timing may be adjusted based on exercise, activity and/or eating patterns. Based on the detected patterns, trends, anomalies, and/or abnormalities, a user device such as a mobile phone or smart device may present prompts for more information, alerts, status updates, and other information intended to improve the user experience.

Abstract: A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.

Abstract: A cover glass made of a glass ceramic that is silica based and has a main crystal phase of high quartz solid solution or keatite solid solution is provided. The cover glass has a stress profile with at least one inflection point at a depth of the cover glass of more than 10 ?m, a thickness from 0.1 mm to 2 mm, and a chemical tempering structure with a surface compressive stress of at least 250 MPa and at most 1500 MPa. A process for producing the cover glass is provided that includes producing a silica based green glass, hot shaping the silica based green glass, thermally treating the silica based green glass with a nucleation step and a ceramization step, and performing an ion exchange at an exchange bath temperature for a duration of time in an exchange bath.

Abstract: A cover glass is provided that includes a silica based glass ceramic with a thickness between 0.4 mm and 0.85 mm. The glass ceramic has a transmittance of more than 80% from 380 nm to 780 nm and a stress attribute selected from: an overall compressive stress (CS) of at least 250 MPa and at most 1500 MPa, a compressive stress at a depth of 30 ?m (CS30) from one of the two faces of at least 160 MPa and at most 525 MPa, a depth of the compression layer (DoCL) of at least 0.2 times the thickness and less than 0.5 times the thickness, and any combinations thereof. The glass ceramic has at least one silica based crystal phase having in a near-surface layer a unit cell volume of at least 1% by volume larger than that of a core where the crystal phase has minimum stresses.

Abstract: The present disclosure provides methods for inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual using an RNA vaccine or using an RNA vaccine in combination with a PD-1 axis binding antagonist. Also provided herein are PD-1 axis binding antagonists and RNA vaccines that include one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual for use in methods of inducing neoepitope-specific CD8+ T cells in an individual or for inducing trafficking of neoepitope-specific CD8+ T cells to a tumor in an individual.

Abstract: A method for multi-dimensional, relaxation-diffusion magnetic resonance fingerprinting (MRF) includes performing, using a magnetic resonance imaging (MRI) system, a pulse sequence that integrates free-waveform b-tensor diffusion encoding into a magnet resonance fingerprinting pulse sequence to perform a multi-dimensional, relaxation-diffusion encoding while acquiring MRF signal evolutions, processing, using a processor, the acquired MRF signal evolutions to determine at least one relaxation parameter and at least one diffusivity parameter, and generating, using the processor, a report including at least one of the at least one relaxation parameter and the at least diffusivity parameter.

Abstract: The present disclosure provides methods, uses, and kits for treating cancer in an individual. The methods comprise administering to the individual a PD-1 axis binding antagonist (such as an anti-PD-1 or anti-PD-L1 antibody) and an RNA vaccine (e.g., a personalized cancer vaccine that comprises one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual). Further provided herein are RNA molecules (e.g., a personalized RNA cancer vaccine that comprises one or more polynucleotides encoding one or more neoepitopes resulting from cancer-specific somatic mutations present in a tumor specimen obtained from the individual), as well as DNA molecules and methods useful for production or use of RNA vaccines.

Abstract: A rail vehicle includes a fuel tank having a tank wall delimiting a tank interior space for storing fuel. At least portions of a first support are connected to the tank wall. A longitudinal support includes first and second longitudinal support portions being offset in longitudinal direction of the vehicle. The fuel tank is disposed in longitudinal direction between the first and second longitudinal support portions. The first support is coupled to the first and second longitudinal support portions. At least portions of the first support are disposed in the tank interior space in the longitudinal direction. The first support running in the longitudinal direction is disposed between the first and second longitudinal support portions. The first support is configured for fully transmitting a force acting between the first and second longitudinal support portions in longitudinal direction of the vehicle.

Abstract: A rail vehicle includes a fuel tank having a tank wall delimiting a tank interior space for storing fuel. At least portions of a first support are connected to the tank wall. A longitudinal support includes first and second longitudinal support portions being offset in longitudinal direction of the vehicle. The fuel tank is disposed in longitudinal direction between the first and second longitudinal support portions. The first support is coupled to the first and second longitudinal support portions. At least portions of the first support are disposed in the tank interior space in the longitudinal direction. The first support running in the longitudinal direction is disposed between the first and second longitudinal support portions. The first support is configured for fully transmitting a force acting between the first and second longitudinal support portions in longitudinal direction of the vehicle.

Abstract: The present invention discloses a new communication infrastructure between a device and a web application that is extended by an inventive proxy. The proxy combines the functionality of each mode of communication of a single device, and presents it as a single device to the web application. This is achieved by the inventive session management of the proxy. The proxy generates for each mode of communication of a single device with the proxy an own single session identifier (ID). Communicating with the web application, the proxy uses only one common session for each single device independently which mode of communication is currently active. The common session is mapped to the respective session of the currently active mode of communication preferably by a common device identifier representing a single device. Each communication between Proxy and device is established by using the session ID of the respective mode of communication.