Abstract: A system and method for generating a mask layout file to eliminate antenna effects in an integrated circuit are disclosed. The method includes analyzing a pattern in a mask layout file to identify a region including an antenna ratio less than a first design rule. A feature located in the identified region is moved based on a second design rule from a first position to a second position in the mask layout file. A grounding feature is placed in the space and automatically connected to a gate feature in the mask layout file such that the antenna ratio is increased to greater than or approximately equal to the first design rule.

Abstract: The present invention is directed to crystals comprising at least part of the estrogen receptor &agr; (ER&agr;) ligand binding domain, optionally bound to a ligand. The present invention is also directed to ligands that bind to ER receptors, and method of designing them. The present invention is also directed to a homology model of the ER&bgr; receptor.

Abstract: The present invention is directed to a culture medium for insect cells, particularly for culturing insect cells for the expression of proteins using a baculovirus expression system, characterized in that the medium does not contain glutamine.