Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a new abeta immunogen variants that enables efficient treatment of Alzheimer's Disease patients by raising specific antibodies against oligimeric and toxic abeta deposits in the brain of Alzheimer's patients.

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.

Abstract: A submersible downhole pump (1) includes an elongate pump unit (3) defining a longitudinal pump axis (L) and a pump unit diameter (D), and at least one cable lug (13) for attaching a cable. The at least one cable lug (13) is connected to the pump unit (3) and pivotable around a pivot axis (P) perpendicular to the longitudinal axis (L) between a defined first position and a defined second position. The at least one cable lug (13) is positioned, in the first position, fully within the pump unit diameter (D). In the second position, the at least one cable lug (13) is positioned at least partially protruding outside the pump unit diameter (D).

Abstract: An electric motor with an electronics housing (6) includes a removable cover (10) as well as an operating unit. The operating unit includes an operating panel (20) fastened on the cover (10). The cover (10) with the operating panel (20) is connectable to a lower part (8) of the electronics housing (6) in at least two alternative alignments. A pump assembly is also provided with such an electric motor.

Abstract: The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Abstract: The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.

Abstract: The present invention relates to new pneumococcal vaccines. The invention also relates to vaccination of subjects, in particular immunocompromised subjects, against pneumoccocal infections using said novel pneumococcal vaccines.

Abstract: An electric motor with a stator housing (2) and with an electronics housing (8), has a first section (A) of the electronics housing arranged on the radial side of the stator housing (2), and a fan (24) arranged on a first axial end (22) of the stator housing (2). The electronics housing (8) extends in the axial direction (X) beyond the first axial end (22) of the stator housing in a manner such that a second section (B) of the electronics housing (8), in whose inside at least one first heat-producing electronic component (58, 60) is arranged, is situated on the radial side of the fan (24). A pump assembly with such an electric motor is also provided.

Abstract: The present invention relates to uses and methods involving Panobinostat and HIV-1. In particular relates the present invention to Panobinostat for use in the treatment of HIV-1 and especially latent HIV-1. This is done using a low dosage of Panobinostat which is highly effective in depleting the HIV-1 reservoir.

Abstract: An electric motor with an electronics housing (6) includes a removable cover (10) as well as an operating unit. The operating unit includes an operating panel (20) fastened on the cover (10). The cover (10) with the operating panel (20) is connectable to a lower part (8) of the electronics housing (6) in at least two alternative alignments. A pump assembly is also provided with such an electric motor.

Abstract: The inventive rotational direction indicator for an electric motor having a cooling fan has a baffle element movable between two positions and which can be arranged on an electric motor with a cooling fan in such a way that the baffle element is positioned in an airstream of the cooling fan whose direction depends on the rotational direction of the electric motor. The baffle element is respectively moved into one of its two positions by the electric motor as a function of the direction of the airstream. The rotational direction indicator has a display unit designed to visually indicate the position of the baffle element and can be arranged on an outer side of the electric motor. The rotational direction indicator has a display actuating unit which connects the display unit and baffle element to one another, and transmits the position of the baffle element to the display unit.

Abstract: The impeller for a centrifugal pump includes a carrier disk and possibly a shroud. The blades of the impeller are identical, but are arranged in pairs such that impellers of different hydraulic characteristics are formed with blades of the same shape.

Abstract: The present invention relates to new pneumococcal vaccines. The invention also relates to vaccination of subjects, in particular immunocompromised subjects, against pneumoccocal infections using said novel pneumococcal vaccines.

Abstract: The invention relates to chimeric polytropic viral envelope polypeptides and uses thereof, as well as to polynucleotides encoding said chimeric polypeptides and constructs comprising said polypeptides and/or polynucleotides. The invention also relates to chimeric retroviral envelope polypeptides, polynucleotides and vectors encoding said chimeric retroviral envelope polypeptides, virus particles and cells harboring said chimeric envelope polypeptides. Said chimeric polypeptide comprise an envelope polypeptide, or fragment thereof, and a polypeptide sequence of a receptor binding region, ligand or polypeptide sequence of a ligand binding region, and optionally a linker sequence. The invention include methods of targeting receptors, methods of treatment and methods for delivery of agents using said chimeric retroviral envelope polypeptides. The invention is applicable for directed targeting and controlled fusion of virus particles with other cellular membranes.

Abstract: An axial face seal (13), which seals a pump housing in the region of the pump shaft (12), is constructed in an axially compact manner. Spring holders (24, 25), which transmit the required pressing force of a compression spring (23), are connected to one another with a positive fit in a rotation direction, and hold a rotating axial face seal ring (19) in a rotationally fixed manner to the pump shaft (12). The spring holders (24, 25) are compact and enclose an abutment ring (33) for pump impellers as well as the compression spring (23). A motor-side spring (24) engages over the rotating axial face seal ring (19), by which an axially extremely short constructional length is achieved.

Abstract: The present invention relates to new pneumococcal vaccines. The invention also relates to vaccination of subjects, in particular immunocompromised subjects, against pneumococcal infections using said novel pneumococcal vaccines.

Abstract: The inventive rotational direction indicator for an electric motor having a cooling fan has a baffle element which can be moved between two positions and which can be arranged on an electric motor with a cooling fan in such a way that the baffle element is positioned in an airstream of the cooling fan whose direction depends on the rotational direction of the electric motor, and said baffle element is respectively moved into one of its two positions by said electric motor as a function of the direction of the airstream. The rotational direction indicator has a display unit which is designed to visually indicate the position of the baffle element and can be arranged on an outer side of the electric motor. In addition, the rotational direction indicator has a display actuating unit which connects the display unit and baffle element to one another, and transmits the position of the baffle element to the display unit.