Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: Systems and methods are described for receiving a plurality of input images, a plurality of depth images, and a plurality of view parameters for generating a virtual view of a target subject. The systems and methods may generate a plurality of warped images based on the plurality of input images, the plurality of view parameters, and at least one of the plurality of depth images. In response to providing the plurality of depth images, the plurality of view parameters, and the plurality of warped images to a neural network, the systems and methods may receive, from the neural network, blending weights for assigning color to pixels of the virtual view of the target subject and may generate, based on the blending weights and the virtual view, a synthesized image according to the view parameters.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

Abstract: A positive displacement pump for conveying material to be conveyed is described, including a measuring assembly with at least one measuring channel, through which at least a portion of the material to be conveyed, which is conveyed by the pump, can flow, wherein the at least one measuring channel has a non-circular cross section and the measuring assembly has a pressure sensor assembly for detecting pressures, which act at positions, which are spaced apart in the flow-through direction of the at least one measuring channel, when the at least one portion of the material to be conveyed, which is conveyed by the pump, flows through the at least one measuring channel. A system with the positive displacement pump and a control unit is further described.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. Compositions optionally comprising a nanoparticle carrier and nucleic acid sequence(s) encoding for (i) a cytokine; and (ii) an innate immune stimulator are provided. Further provided are compositions optionally comprising a nanoparticle carrier; an innate immune stimulator; and a nucleic acid sequence encoding for a cytokine. Methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.

Abstract: The present invention features compositions and methods for amplifying a target oligonucleotide in a sample, including detection of the target oligonucleotide in real time.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: An agitator mill including a grinding chamber containing grinding bodies and an agitator shaft, which revolves therein around a horizontal axis and which supports several grinding disks, which are connected thereto and which are spaced apart from one another in the direction of the horizontal axis and which move the grinding bodies, wherein grinding disks preferably in each case have slits or apertures, wherein adjacent grinding disks are arranged on the agitator shaft so that the ratio of the grinding chamber length to the radial grinding chamber height is greater than or equal to 2:3, and that the radial distance between the outer jacket surface of the grinding disks and the inner wall of the grinding container limiting the grinding chamber is more than 20% of the radial grinding chamber height.

Abstract: This invention relates to recombinant human antibody molecules. The antibodies bind fungal antigens, for example from Candida spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.

Abstract: There is provided mechanisms for selecting links for running cooperative communication between access points in a communication network. A method is performed by a controller. The method comprises estimating, as a function of live network data obtained from the access points, a link utility for each link between each pair of access points as achieved if running the cooperative communication on said link. The method comprises selecting, as a function of the respective estimated link utility for each pair of access points, a subset of all links between the access points yielding optimal total aggregated link utility for a condition on a maximum number of links per access points for running the cooperative communication.

Abstract: Systems and methods for training a neural radiance field model for noisy scenes can leverage raw noisy images in linear high dynamic range color space to train a neural radiance field model to generate view synthesis of low light and/or high contrast scenes. The trained model can then be utilized to accurately complete view rendering tasks without the preprocessing used for generating low dynamic range images. In some implementations, training on unprocessed data of a low light scene can allow for training a neural radiance field model to generate high quality view renderings of a low light scene.

Abstract: An end effector for handling a sheet of flexible material. The end effector includes a support frame and manipulator assemblies, each attached to the support frame by a support mount. The manipulator assemblies include a holding tool having a lifting surface. The manipulator assemblies include a linear actuator, and the holding tool is connected to the linear actuator by a multiaxial joint. A drive provides—the displacement of the holding tool by the linear actuator. The end effector includes resilient members each rigidly affixed to two adjacent holding tools and positioned in a space providing a mutual distance between opposing faces of the adjacent holding tools, where each holding tool is connected to—adjacent holding tools—by the resilient members. The resilient members are configured to non-permanently deform in the space when adjacent holding tools are displaced relative to each other along displacement axes.

Abstract: The disclosure provides nanoparticle and nucleic acid compositions and methods of making and using the same to deliver multiple bioactive agents such as a nucleic acid encoding a viral antigen or a tumor antigen to a subject. Various nanoparticle carriers are described. Various nucleic acids encoding viral and tumor antigens are described. In some instances, the nanoparticle component may include a hydrophobic core having an inorganic particle, and optionally a membrane having a cationic lipid.

Abstract: A process for line production of plant growth medium pots or bags with a closed bottom end includes the steps of: i) continuously folding the free end of a continuous length of water and air permeable sheet material into a sheet material tube around and beyond a free end of a growth medium feeding tube; ii) forming a first sealing in the sheet material tube; iii) filling the sheet material tube with a measured amount of growth medium; iv) forming a second sealing in the sheet material tube; v) separating the part of the sheet material tube positioned downstream from the second sealing to form a first plant growth medium pot or bag with a closed end, repeating as needed to form a plurality of plant growth medium pots or bags.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

Abstract: A connector for electric vehicle supply equipment includes: a housing that includes one or more electrical coupling members that are connectable between the electric vehicle supply equipment and a mating inlet of an electric vehicle to supply electric power to the vehicle. The housing includes a sensor for detecting light within the housing and outputting a signal in response to a detection of light within the housing to interrupt or disable the supply of electric power to the vehicle through the connector.

Abstract: An electric Vehicle Supply Equipment (EVSE) multichannel insulation monitoring device (MIMD) for insulation monitoring or earth leakage current monitoring, wherein the EVSE multichannel insulation monitoring device comprises multiple monitoring channels and wherein the EVSE multichannel insulation monitoring device includes a control and monitor device configured to individually monitor the insulation or earth leakage current of each monitoring channel.

Abstract: The disclosure provides nanoparticle compositions and methods of making and using the same to deliver a bioactive agent such as a nucleic acid which is a PRR agonist to a subject. Various nanoparticle carriers are described. In some instances, the nanoparticle component may include a hydrophobic core having an inorganic particle, and optionally a membrane having a cationic lipid. Various PRR agonists are described. In some instances, the PRR agonist is a RIG-I agonist or a TLR3 agonist.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: A connector for electric vehicle supply equipment includes: a housing; a first electrical coupling member supported by the housing and that mates with an inlet of an electric vehicle, the first electrical coupling member including a first pin part; a second electrical coupling member supported by the housing and that mates with the inlet, the second electrical coupling member including a second pin part; and a conductive barrier supported by the housing that extends between the first and second pin parts. The conductive barrier interacts with at least one of the first and second pin parts to provide a conduction path for electrical power monitorable to evaluate electrical isolation of the first and second electrical coupling members and avoid electrical arcing or short-circuiting.