Abstract: The disclosure provides, at least in part, to a method for producing high titer lentiviral vectors, and for producing lentiviral particles carrying a transgene of interest and under satisfactory safety conditions. The disclosure also provides at least in part, methods of purification of such lentiviral particle, e.g., from a cell culture. The disclosure also provides a formulation to lentiviral preparations that maintain structural integrity of the viral vector during purification, storage, and gene transfer events.

Abstract: According to an aspect there is provided an inflation apparatus (10) for use in an inflation-based non-invasive blood pressure, NIBP, measurement apparatus, the inflation apparatus comprising: an outlet (110) configured to be coupled to a cuff of the inflation-based NIBP measurement apparatus; a plurality of pumps (120) each configured to output a flow of gas to the outlet; and a control unit (130) configured to enable at least one of the plurality of pumps to output a flow of gas to the outlet based on a required flow rate to inflate the cuff and/or to control a flow rate of at least one of the plurality of pumps to output a flow of gas to the outlet based on a required flow rate to inflate the cuff.

Abstract: The present invention relates to a device, system and method for detection of pulse and/or pulse-related information of a patient.

Abstract: According to an aspect there is provided a method of determining a calibration parameter for a first blood pressure, BP, measurement device, the method comprising obtaining a first physiological characteristic measurement of a subject using the first BP measurement device, wherein the first BP measurement device is for obtaining physiological characteristic measurements of a physiological characteristic of the subject and for determining a BP measurement of the subject from the physiological characteristic measurements using the calibration parameter, wherein the first physiological characteristic measurement is obtained when a torso of the subject is in a first posture; obtaining a second physiological characteristic measurement of the subject using the first BP measurement device, wherein the second physiological characteristic measurement is obtained when the torso of the subject is in a second, different, posture; determining the change in the posture of the torso from the first posture to the second post

Abstract: The present invention relates to an apparatus and method for determining blood pressure of a subject. To automatically trigger calibration the apparatus comprises a sensor signal input configured to obtain an arterial pulse wave sensor signal of the subject, a feature extraction unit configured to extract multiple features from the obtained arterial pulse wave sensor signal, an estimation unit configured to determine multiple blood pressure estimation values for individual extracted features and/or groups of extracted features and to determine the subject's blood pressure from said multiple blood pressure estimation values, a calibration unit configured to calibrate the estimation unit based on blood pressure reference measurements, and a calibration trigger unit configured to trigger calibration by the calibration unit if the multiple blood pressure estimation values diverge more than a divergence limit.

Abstract: A method for monitoring fetal health. The method of the present disclosure comprises transmitting (100) an ultrasound signal from an at least one transducer element in an array towards a maternal abdomen. An at least one ultrasonic echo signal corresponding to an at least one depth of the maternal abdomen is then received (102) by the at least one transducer element. The at least one Doppler signal is determined after the echo is received by the at least one transducer element is then processed (104) in an at least one channel. A multidimensional map is then generated (106) from the processed Doppler signal. A feedback (114) to reposition the at least one transducer element is then provided when the fetal heart is determined to lie outside an ultrasound beam volume.

Abstract: The present invention relates to a pregnancy monitoring system, the system comprising a fetal monitoring transducer (20) arranged to detect fetal medical condition information; and a control device (48) comprising a motion assessment unit (50) and a signal output unit (52); wherein the fetal monitoring transducer (20) is arranged to detect fetal movement indicative information, wherein the motion assessment unit (50) is arranged to process fetal movement grading information, in addition to the fetal movement indicative information, wherein the signal output unit (52) is arranged to simultaneously output a fetal condition signal, particularly a fetal heart rate signal, and an augmented fetal movement signal based on the fetal movement indicative information and the fetal movement grading information, wherein a characteristic property of the original fetal movement information is still present in the augmented fetal movement signal. The disclosure further relates to a corresponding pregnancy monitoring method.

Abstract: According to an aspect, there is provided a method of operating a non-invasive blood pressure, NIBP, monitor to measure the blood pressure of a subject, the NIBP monitor comprising a cuff, a pressure sensor for measuring the pressure in the cuff and for outputting a pressure signal representing the pressure in the cuff and a physiological parameter sensor, the method comprising obtaining a first measurement of a physiological parameter for the subject during inflation of the cuff, the first measurement being obtained from the pressure signal; obtaining a second measurement of the physiological parameter for the subject during inflation of the cuff, the second measurement being obtained from the physiological parameter sensor; comparing the first measurement and the second measurement; and estimating the reliability of a blood pressure measurement obtained by the NIBP monitor during inflation of the cuff based on the result of the step of comparing.

Abstract: The present invention relates to a pregnancy monitoring system, the system comprising a fetal monitoring transducer (20) arranged to detect fetal medical condition information; and a control device (48) comprising a motion assessment unit (50) and a signal output unit (52); wherein the fetal monitoring transducer (20) is arranged to detect fetal movement indicative information, wherein the motion assessment unit (50) is arranged to process fetal movement grading information, in addition to the fetal movement indicative information, wherein the signal output unit (52) is arranged to simultaneously output a fetal condition signal, particularly a fetal heart rate signal, and an augmented fetal movement signal based on the fetal movement indicative information and the fetal movement grading information, wherein a characteristic property of the original fetal movement information is still present in the augmented fetal movement signal. The disclosure further relates to a corresponding pregnancy monitoring method.

Abstract: The present invention relates to a pregnancy monitoring system (10) and to a method for detecting medical condition information from a pregnant subject of interest (12).

Abstract: There is provided an apparatus (12) for use with a wearable cuff (14). The wearable cuff (14) is for use in measuring blood pressure. The apparatus (12) is configured to acquire a plurality of pressure signals. Each of the plurality of pressure signals are indicative of a pressure in the wearable cuff (14) during a period for measuring blood pressure. The apparatus (12) is configured to, for each of the plurality of acquired pressure signals, determine a measure of a quality of the acquired pressure signal based on one or more parameters derived from artifacts identified in the acquired pressure signal. The apparatus (12) is also configured to determine a measure of a quality of the wearable cuff (14) based on the determined measures of the quality of the acquired pressure signals.

Abstract: According to an aspect, there is provided a computer-implemented method of estimating a trend in a blood pressure surrogate, the method comprising obtaining a set of blood pressure surrogate measurement values of a blood pressure surrogate for a subject; obtaining, for each blood pressure surrogate measurement value, an error value indicating a measurement error for the blood pressure surrogate measurement value; and analysing the set of blood pressure surrogate measurement values and the respective error values using Bayesian inference to determine a trend (4) in the blood pressure surrogate over time.

Abstract: The present invention relates to an apparatus (18) for providing a control signal for a blood pressure measurement device, comprising: an input interface (24) for obtaining a health state parameter being indicative of a health state of a patient (12); a processing unit (28) for determining one or more operation settings of a blood pressure measurement device (14) based on the health state parameter, said one or more operation settings including a parameter that can be adjusted at the blood pressure measurement device (14) when conducting a blood pressure measurement with the device and that affects a precision of said blood pressure measurement and a patient comfort resulting from said blood pressure measurement; and a control interface (30) for providing a control signal for a blood pressure measurement device (14) to perform a blood pressure measurement based on said one or more operation settings. The present invention further relates to a corresponding method.

Abstract: According to an aspect there is provided an inflation apparatus (10) for use with an inflation-based non-invasive blood pressure, NIBP, measurement apparatus, the inflation apparatus comprising: an outlet (110) configured to be coupled to a cuff of the inflation-based NIBP measurement apparatus; a pump (120) configured to output a flow of gas at an output flow rate; a valve (130) disposed along a flow path between the pump and the outlet to selectively pass part of the flow of gas output by the pump; and a control unit (140) configured to control the flow resistance of the valve to provide a flow of gas to the outlet at a required flow rate for inflating the cuff.

Abstract: According to an aspect there is provided an inflation apparatus (10) for use in an inflation-based non-invasive blood pressure, NIBP, measurement apparatus, the inflation apparatus comprising: an outlet (110) configured to be coupled to a cuff of the inflation-based NIBP measurement apparatus; a plurality of pumps (120) each configured to output a flow of gas to the outlet; and a control unit (130) configured to enable at least one of the plurality of pumps to output a flow of gas to the outlet based on a required flow rate to inflate the cuff and/or to control a flow rate of at least one of the plurality of pumps to output a flow of gas to the outlet based on a required flow rate to inflate the cuff.

Abstract: The present invention relates to an apparatus and method for determining blood pressure of a subject. To automatically trigger calibration the apparatus comprises a sensor signal input (31) configured to obtain an arterial pulse wave sensor signal (11) of the subject, a feature extraction unit (32) configured to extract multiple features (42) from the obtained arterial pulse wave sensor signal, an estimation unit (33) configured to determine multiple blood pressure estimation values (43) for individual extracted features and/or groups of extracted features and to determine the subject's blood pressure (44) from said multiple blood pressure estimation values, a calibration unit (34) configured to calibrate the estimation unit (33) based on blood pressure reference measurements (21), and a calibration trigger unit (35) configured to trigger calibration by the calibration unit (34) if the multiple blood pressure estimation values diverge more than a divergence limit.

Abstract: The present invention relates to a device, system and method for detection of pulse and/or pulse-related information of a patient.

Abstract: Method of operating a non-invasive blood pressure, NIBP, monitor to measure the blood pressure of a subject, the NIBP monitor comprising a cuff, a pressure sensor for measuring the pressure in the cuff and for outputting a pressure signal representing the pressure in the cuff and a physiological parameter sensor, the method comprising obtaining a first measurement of pulse rate or heart rate for the subject during inflation of the cuff, the first measurement being obtained from the pressure signal; obtaining a second measurement of the pulse rate or heart rate for the subject during inflation of the cuff, the second measurement being obtained from the physiological parameter sensor; comparing the first measurement and the second measurement; and estimating the reliability of a blood pressure measurement obtained by the NIBP monitor during inflation of the cuff based on the result of the step of comparing.

Abstract: According to an aspect there is provided a method of determining a calibration parameter for a first blood pressure, BP, measurement device, the method comprising obtaining a first physiological characteristic measurement of a subject using the first BP measurement device, wherein the first BP measurement device is for obtaining physiological characteristic measurements of a physiological characteristic of the subject and for determining a BP measurement of the subject from the physiological characteristic measurements using the calibration parameter, wherein the first physiological characteristic measurement is obtained when a torso of the subject is in a first posture; obtaining a second physiological characteristic measurement of the subject using the first BP measurement device, wherein the second physiological characteristic measurement is obtained when the torso of the subject is in a second, different, posture; determining the change in the posture of the torso from the first posture to the second post

Abstract: According to an aspect, there is provided a method of operating a non-invasive blood pressure, NIBP, monitor to measure the blood pressure of a subject, the NIBP monitor comprising a cuff, a pressure sensor for measuring the pressure in the cuff and for outputting a pressure signal representing the pressure in the cuff and a physiological parameter sensor, the method comprising obtaining a first measurement of a physiological parameter for the subject during inflation of the cuff, the first measurement being obtained from the pressure signal; obtaining a second measurement of the physiological parameter for the subject during inflation of the cuff, the second measurement being obtained from the physiological parameter sensor; comparing the first measurement and the second measurement; and estimating the reliability of a blood pressure measurement obtained by the NIBP monitor during inflation of the cuff based on the result of the step of comparing.