Abstract: The present invention describes 2-methyl-quinazoline compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions. The 2-methyl substituted quinazoline compounds of general formula (I) effectively and selectively inhibit the Ras-Sos interaction without significantly targeting the EGFR receptor. They are therefore useful for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, such as cancer as a sole agent or in combination with other active ingredients.

Abstract: A recuperative gas burner for industrial applications can include a combustion chamber and a burner tip providing an outlet opening of the combustion chamber. The gas burner includes a gas supply for combustion gas having a first gas supply duct and a second gas supply duct. The combustion gas can be provided to the combustion chamber through the first gas supply duct. The combustion gas can also be provided to the burner tip through the second gas supply duct. The gas burner can include an air supply for combustion air and an exhaust gas flow channel for exhaust gas, wherein the exhaust gas flow channel and the air supply are configured such that combustion air can be heated by the exhaust gas.

Abstract: A preconditioned air unit for supplying preconditioned air to an aircraft parked on the ground, the preconditioned air unit comprising a main unit with a housing accommodating a flow duct with an air inlet for ambient air and an air outlet for connection to the parked aircraft, a blower connected with the flow duct for generation of an air flow from the air inlet toward the air outlet, and a plurality of compartments, each of which is configured for accommodation of a self-contained cooling module comprising at least one refrigeration system, each of which includes at least one compressor, at least one condenser, at least one expansion valve, and at least one evaporator connected in a flow circuit containing a refrigerant, and wherein each compartment is further configured so that the at least one evaporator interacts with the air flow in the flow duct when the self-contained cooling module is installed in the compartment, and wherein at least one self-contained cooling module is installed in the plurality of

Abstract: A preconditioned air unit for supplying preconditioned air to an aircraft parked on the ground, the preconditioned air unit comprising a housing accommodating a flow duct with an air inlet for ambient air and an air outlet for connection to the parked aircraft, a blower connected with the flow duct for generation of an air flow from the air inlet toward the air outlet, at least one refrigeration system, each of which includes at least one compressor, at least one condenser, at least one expansion valve, and at least one evaporator connected in a flow circuit containing a refrigerant, and wherein the at least one evaporator interacts with the air flow in the flow duct, and at least one variable frequency driver for power supply of at least one of the at least one compressor of the at least one refrigeration system.

Abstract: A preconditioned air unit for supplying preconditioned air to an aircraft parked on the ground, the preconditioned air unit comprising a main unit with a housing accommodating a flow duct with an air inlet for ambient air and an air outlet for connection to the parked aircraft, a blower connected with the flow duct for generation of an air flow from the air inlet toward the air outlet, and a plurality of compartments, each of which is configured for accommodation of a self-contained cooling module comprising at least one refrigeration system, each of which includes at least one compressor, at least one condenser, at least one expansion valve, and at least one evaporator connected in a flow circuit containing a refrigerant, and wherein each compartment is further configured so that the at least one evaporator interacts with the air flow in the flow duct when the self-contained cooling module is installed in the compartment, and wherein at least one self-contained cooling module is installed in the plurality of

Abstract: A preconditioned air unit for supplying preconditioned air to an aircraft parked on the ground, the preconditioned air unit comprising a housing accommodating a flow duct with an air inlet for ambient air and an air outlet for connection to the parked aircraft, a blower connected with the flow duct for generation of an air flow from the air inlet toward the air outlet, at least one refrigeration system, each of which includes at least one compressor, at least one condenser, at least one expansion valve, and at least one evaporator connected in a flow circuit containing a refrigerant, and wherein the at least one evaporator interacts with the air flow in the flow duct, and at least one variable frequency driver for power supply of at least one of the at least one compressor of the at least one refrigeration system.