Abstract: A cartridge for holding a liquid and for use in a medical delivery device has an elongate barrel provided with a central axis and having a first opening at a first end thereof and a second opening at a second end thereof. The first opening is sealed off by a first sealing means provided with a puncturing area to be punctured by a conduit, such as a hollow needle, and the second opening is sealed off by a stopper that is in intimate contact with a general inner surface of the barrel and is movable within the barrel towards the first sealing means. The puncturing area of the first sealing means is located radially outside the general inner surface of the barrel.