Patents by Inventor Lars Stiens

Lars Stiens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZING THE PRODUCTION OF ANTIBODIES
    Publication number: 20190218305
    Abstract: A general method is provided for the production of purified antibodies by separation of an antibody molecule from an antibody variant by chromatographic methods, e.g. to enhance therapeutic efficacy, by for example choosing a specific harvesting time point and/or a specific purification scheme.
    Type: Application
    Filed: July 26, 2018
    Publication date: July 18, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Josef Burg, Bernhard Hilger, Thorsten Kaiser, Wolfgang Kuhne, Lars Stiens, Claus Wallerius, Frank Zettl
  • OPTIMIZING THE PRODUCTION OF ANTIBODIES
    Publication number: 20160102149
    Abstract: A general method is provided for the production of purified antibodies by separation of an antibody molecule from an antibody variant by chromatographic methods, e.g. to enhance therapeutic efficacy, by for example choosing a specific harvesting time point and/or a specific purification scheme. The current invention thus reports a method for producing an antibody composition comprising an antibody molecule and a variant thereof, comprising the following steps: providing a sample comprising the antibody molecule and a variant thereof, determining the presence of the antibody molecule and/or a variant thereof and/or the ratio of the amount of the antibody molecule or variant thereof to the sum of the amounts of the antibody molecule and the variant thereof, in an aliquot of said sample, determining a subsequent harvesting time point and/or antibody purification scheme on basis of the data obtained before, thereby producing an antibody composition comprising the antibody molecule and a variant thereof.
    Type: Application
    Filed: December 18, 2015
    Publication date: April 14, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Josef Burg, Bernhard Hilger, Thorsten Kaiser, Wolfgang Kuhne, Lars Stiens, Claus Wallerius, Frank Zettl
  • OPTIMIZING THE PRODUCTION OF ANTIBODIES
    Publication number: 20120177640
    Abstract: A general method is provided for the production of purified antibodies by separation of an antibody molecule from an antibody variant by chromatographic methods, e.g. to enhance therapeutic efficacy, by for example choosing a specific harvesting time point and/or a specific purification scheme. The current invention thus reports a method for producing an antibody composition comprising an antibody molecule and a variant thereof, comprising the following steps: providing a sample comprising the antibody molecule and a variant thereof, determining the presence of the antibody molecule and/or a variant thereof and/or the ratio of the amount of the antibody molecule or variant thereof to the sum of the amounts of the antibody molecule and the variant thereof, in an aliquot of said sample, determining a subsequent harvesting time point and/or antibody purification scheme on basis of the data obtained before, thereby producing an antibody composition comprising the antibody molecule and a variant thereof.
    Type: Application
    Filed: July 22, 2010
    Publication date: July 12, 2012
    Inventors: Josef Burg, Bernhard Hilger, Thorsten Kaiser, Wolfgang Kuhne, Lars Stiens, Claus Wallerius, Frank Zettl