Patents by Inventor Lars Stoeckl

Lars Stoeckl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20240002841
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 5, 2023
    Publication date: January 4, 2024
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20230374501
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 5, 2023
    Publication date: November 23, 2023
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • Means and methods for modifying multiple alleles
    Patent number: 11713458
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: August 1, 2023
    Assignee: Octapharma AG
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • METHODS AND COMPOSITIONS FOR PREPARING SURFACTANT PROTEIN D (SP-D)
    Publication number: 20220042036
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Application
    Filed: March 25, 2021
    Publication date: February 10, 2022
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • Methods and compositions for preparing surfactant protein D (SP-D)
    Patent number: 10975389
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: April 13, 2021
    Assignee: Airway Therapeutics, Inc.
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • METHODS, COMPOSITIONS AND CELLS FOR PREPARING SURFACTANT PROTEIN D (SP-D)
    Publication number: 20200407747
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Application
    Filed: July 16, 2020
    Publication date: December 31, 2020
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • Methods, compositions and cells for preparing surfactant protein D (SP-D)
    Patent number: 10752914
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: August 25, 2020
    Assignees: Airway Therapeutics, Inc., Glycotope GmbH
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • USE OF HUMAN CELLS OF MYELOID LEUKAEMIA ORIGIN FOR EXPRESSION OF ANTIBODIES
    Publication number: 20190359731
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Application
    Filed: April 5, 2019
    Publication date: November 28, 2019
    Inventors: Steffen GOLETZ, Antje DANIELCZYK, Hans BAUMEISTER, Renate STAHN, Anja LOEFFLER, Lars STOECKL
  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20190185848
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 20, 2017
    Publication date: June 20, 2019
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • Use of human cells of myeloid leukemia origin for expression of antibodies
    Patent number: 10280230
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: May 7, 2019
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Antje Danielczyk, Hans Baumeister, Renate Stahn, Anja Loeffler, Lars Stoeckl
  • METHODS AND COMPOSITIONS FOR PREPARING SURFACTANT PROTEIN D (SP-D)
    Publication number: 20190071694
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 7, 2019
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • METHODS, COMPOSITIONS AND CELLS FOR PREPARING SURFACTANT PROTEIN D (SP-D)
    Publication number: 20190071693
    Abstract: Some embodiments of the methods and compositions provided herein relate to the preparation surfactant protein-D (SP-D). Some embodiments include the expression of human SP-D in certain cell lines, and the purification of human SP-D from such cell lines. Some embodiments include the preparation of certain oligomeric forms of human SP-D.
    Type: Application
    Filed: September 4, 2018
    Publication date: March 7, 2019
    Inventors: Jan Susan Rosenbaum, Frederick Gyapon Quast, Matthias Kaup, Lars Stöckl
  • MAMMALIAN FOLLICLE-STIMULATING HORMONE COMPOSITION WITH INCREASED STABILITY
    Publication number: 20180264086
    Abstract: The present invention pertains to the field of gonadotropins. In particular, an improved composition comprising recombinant human follicle-stimulating hormone and chlorocresol is provided. This improved composition has an increased stability at high temperatures and is useful in the treatment of infertility, in particular in human patients.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 20, 2018
    Inventors: Steffen Goletz, Lars Stoeckl
  • CONTROLLED OVARIAN HYPERSTIMULATION WITH IMPROVED RECOMBINANT HUMAN FOLLICLE-STIMULATING HORMONE
    Publication number: 20170035854
    Abstract: The present invention pertains to methods for controlled ovarian hyperstimulation in a female subject using improved recombinant human follicle-stimulating hormone (rhFSH). The methods result in a high number of fertilizable oocytes even at low amounts of FSH administered to the female subject.
    Type: Application
    Filed: April 17, 2015
    Publication date: February 9, 2017
    Inventors: Steffen GOLETZ, Lars STÖCKL
  • Recombinant human follicle-stimulating hormone
    Patent number: 9527899
    Abstract: The present invention pertains to improved FSH preparations which are capable of stimulating sex steroid release at much lower concentration than the commonly used urinary FSH or recombinant FSH obtained from CHO cells and which act independent of cAMP signaling These improved FSH preparations can be used in infertility treatment.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: December 27, 2016
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Lars Stöckl
  • Fab-glycosylated antibodies
    Patent number: 9359439
    Abstract: The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates attached to the Fab part of the antibodies. Furthermore, the present invention provides antibodies having an increased circulation half-life.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: June 7, 2016
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Antje Danielczyk, Lars Stoeckl
  • USE OF HUMAN CELLS OF MYELOID LEUKAEMIA ORIGIN FOR EXPRESSION OF ANTIBODIES
    Publication number: 20150368363
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Application
    Filed: May 4, 2015
    Publication date: December 24, 2015
    Inventors: Steffen GOLETZ, Antje DANIELCZYK, Hans BAUMEISTER, Renate STAHN, Anja LOEFFLER, Lars STOECKL
  • Use of human cells of myeloid leukaemia origin for expression of antibodies
    Patent number: 9051356
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: June 9, 2015
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Antje Danielczyk, Hans Baumeister, Renate Stahn, Anja Löffler, Lars Stöckl
  • FAB-GLYCOSYLATED ANTIBODIES
    Publication number: 20130209458
    Abstract: The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates attached to the Fab part of the antibodies. Furthermore, the present invention provides antibodies having an increased circulation half-life.
    Type: Application
    Filed: August 10, 2011
    Publication date: August 15, 2013
    Applicant: GLYCOTOPE GMBH
    Inventors: Steffen Goletz, Antje Danielczyk, Lars Stoeckl
  • PROCESS FOR THE PURIFICATION OF GLYCOPROTEINS
    Publication number: 20120329092
    Abstract: The present invention relates to a process for the purification of a glycoprotein comprising subjecting a liquid containing said glycoprotein to the steps of: a) reverse phase chromatography, b) boronate affinity chromatography, and c) size exclusion chromatography. Also provided is a manufacturing process for producing a glycoprotein of interest.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 27, 2012
    Applicant: Glycotope GmbH
    Inventors: Steffen Goletz, Lars Stöckl