Patents by Inventor Lars Stoeckl

Lars Stoeckl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20240002841
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 5, 2023
    Publication date: January 4, 2024
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20230374501
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 5, 2023
    Publication date: November 23, 2023
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • Means and methods for modifying multiple alleles
    Patent number: 11713458
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: August 1, 2023
    Assignee: Octapharma AG
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • USE OF HUMAN CELLS OF MYELOID LEUKAEMIA ORIGIN FOR EXPRESSION OF ANTIBODIES
    Publication number: 20190359731
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Application
    Filed: April 5, 2019
    Publication date: November 28, 2019
    Inventors: Steffen GOLETZ, Antje DANIELCZYK, Hans BAUMEISTER, Renate STAHN, Anja LOEFFLER, Lars STOECKL
  • MEANS AND METHODS FOR MODIFYING MULTIPLE ALLELES
    Publication number: 20190185848
    Abstract: The present invention relates to a method of modifying at least one gene in a cell via CRISPR/Cas, wherein the at least one gene has at least three alleles. The present invention further relates to cells obtainable by the method of the invention. Additionally, the present invention provides a method of producing a protein in a cell obtainable by the method of modifying at least one gene of the invention. Moreover, the invention relates to proteins obtainable by the method of producing a protein and use thereof, for example in therapy.
    Type: Application
    Filed: June 20, 2017
    Publication date: June 20, 2019
    Inventors: Karina Nawrath, Janine Guendel, Sven Bahrke, Lars Stoeckl, Steffen Goletz
  • Use of human cells of myeloid leukemia origin for expression of antibodies
    Patent number: 10280230
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: May 7, 2019
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Antje Danielczyk, Hans Baumeister, Renate Stahn, Anja Loeffler, Lars Stoeckl
  • MAMMALIAN FOLLICLE-STIMULATING HORMONE COMPOSITION WITH INCREASED STABILITY
    Publication number: 20180264086
    Abstract: The present invention pertains to the field of gonadotropins. In particular, an improved composition comprising recombinant human follicle-stimulating hormone and chlorocresol is provided. This improved composition has an increased stability at high temperatures and is useful in the treatment of infertility, in particular in human patients.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 20, 2018
    Inventors: Steffen Goletz, Lars Stoeckl
  • Fab-glycosylated antibodies
    Patent number: 9359439
    Abstract: The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates attached to the Fab part of the antibodies. Furthermore, the present invention provides antibodies having an increased circulation half-life.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: June 7, 2016
    Assignee: Glycotope GmbH
    Inventors: Steffen Goletz, Antje Danielczyk, Lars Stoeckl
  • USE OF HUMAN CELLS OF MYELOID LEUKAEMIA ORIGIN FOR EXPRESSION OF ANTIBODIES
    Publication number: 20150368363
    Abstract: The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition.
    Type: Application
    Filed: May 4, 2015
    Publication date: December 24, 2015
    Inventors: Steffen GOLETZ, Antje DANIELCZYK, Hans BAUMEISTER, Renate STAHN, Anja LOEFFLER, Lars STOECKL
  • FAB-GLYCOSYLATED ANTIBODIES
    Publication number: 20130209458
    Abstract: The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates attached to the Fab part of the antibodies. Furthermore, the present invention provides antibodies having an increased circulation half-life.
    Type: Application
    Filed: August 10, 2011
    Publication date: August 15, 2013
    Applicant: GLYCOTOPE GMBH
    Inventors: Steffen Goletz, Antje Danielczyk, Lars Stoeckl