Abstract: A device for applying active substances to surfaces of medical implants (11) has a base station (22) and a replaceable cartridge (10) that can be mounted on the base station, the cartridge (10) having a holder for the implants (11) and also a nozzle for spraying the active substance onto the surface. The base station (22) has a drive unit (75) for moving the holder and the nozzle in relation to each other. For this purpose, the cartridge (10) has a basically cylindrical first housing part (14) which has the holder and a basically cylindrical second housing part (15) which has the nozzle. The first and second housing parts (14, 15) are formed so that they fit into each other and are arranged so that they can be moved, and preferably rotated, relative to each other (FIG. 8).