Abstract: Disclosed are method for determining coronaviruses, in particular to methods in which the determination is performed using lectins adapted to bind coronavirus glycoproteins. Also disclosed are kits to facilitate performing the method.

Abstract: The present invention relates to a method for determining a lectin-binding glycan indicative to traumatic brain injury (TBI) wherein the determining is based on detection of the lectin-binding glycan in a fluid sample using lectins of similar glycan binding property for tracing and capturing.

Abstract: Disclosed is a device for conducting a non-invasive diagnostic test in a subject suspected of suffering brain injury. The device for diagnosing a brain injury in a subject includes a probe of a porous matrix, an indicator formulation disposed on the porous matrix and includes at least one lectin and/or antibody capable of selectively binding to a glycan-based biomarker indicative of brain injury in a sample, and a visually detectable label; and a handle in communication with the probe, wherein at least one of the lectin and/or antibody and/or the visually detectable label is immobilized in and/or on a detection zone in the porous matrix, and the visually detectable label develops a color intensity level and becomes visible upon a binding event of the glycan-based biomarker to the lectin and/or antibody. Also provided is a method for using the device described below and methods for producing the same.

Abstract: A high capacity solid phase for bioaffinity assays and other solid phase applications prepared by coating a solid support with an analyte-specific biomolecule in the presence of a zwitterionic additive is described. Structures prepared according to the invention provide high capacity solid phases with enhanced binding properties, which are advantageous for any solid phase based assay.

Abstract: A high capacity solid phase for bioaffinity assays and other solid phase applications prepared by coating a solid support with an analyte-specific biomolecule in the presence of a zwitterionic additive is described. Structures prepared according to the invention provide high capacity solid phases with enhanced binding properties, which are advantageous for any solid phase based assay.