Patents by Inventor Laszlo Gabor
Laszlo Gabor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8318743Abstract: The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H)pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.Type: GrantFiled: July 3, 2007Date of Patent: November 27, 2012Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo ReszvenytarsasagInventors: Istvan Gacsalyi, Gabor Gigler, Marta Agoston, Hajnalka Kompagne, Szabolcs Kertesz, Krisztina Moricz, Gyoergy Levay, Gabor Szenas, Lászlo Gabor Harsing, Jozsef Barkoczy, Gyula Simig
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Publication number: 20120252784Abstract: Novel 2,3,4-benzothiadiazepines-2,2-dioxides and processes for the preparation thereof are disclosed. The compounds influence the central nervous system and may be used to treat or prevent Alzheimer's disease, Parkinson's disease or Huntington's disease, senile dementia not of the Alzheimer's type, vascular dementia, post-stroke dementia, Korsakoff's syndrome, Down's syndrome, schizophrenia, panic disorder, post-traumatic stress disorder, anxiety or depression.Type: ApplicationFiled: March 13, 2012Publication date: October 4, 2012Inventors: Jozsef FETTER, Ferenc BERTHA, Balazs MOLNAR, Gyula SIMIG, Jozsef BARKOCZY, Balazs VOLK, Gyoergy LEVAY, Istvan GACSALYI, Gabor GIGLER, Hajnalka KOMPAGNE, Bernadett MARKO, Katalin NAGY, Peter KIRICSI, Laszlo Gabor HARSING, Gabor SZENASI
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Publication number: 20120108607Abstract: The present invention relates to the enantiomers of 5,7-dichloro-3-{4-[4-(4-chlorophenyl)-piperazin-1-yl]butyl}-3-ethyl-1,3-dihydro-2H-indol-2-one of the Formula (II) pharmaceutically acceptable salts thereof, process for the preparation thereof, medicinal products containing said enantiomers and the use thereof and their pharmaceutically acceptable salts in the treatment of the disorders of the central nervous system.Type: ApplicationFiled: February 5, 2010Publication date: May 3, 2012Inventors: Balázs Volk, József Barkóczy, István Gacsalyi, Elemér Fogassy, József Schindler, Gábor Gigler, Hajnalka Kompagne, Iidikó Nagyné Gyoenos, Katalin Pallagi, Márta Porcs-Makkay, Gábor Szénási, Tibor Mezel, Gyula Lukács, Gyoergy Lévay, András Egyed, László Gábor Hársing
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Patent number: 7960375Abstract: The invention relates to new 8-chloro-2,3-benzodiazepine derivatives of the general formula (I), wherein R stands for a lower alkyl group or a group of the general formula —NH—R?, wherein R? stands for a lower alkyl or a lower cycloalkyl group), and pharmaceutically acceptable acid addition salts thereof. The invention also encompasses a process for the preparation of said compounds, pharmaceutical compositions containing them and new intermediates useful for the preparation of the new 8-chloro-2,3-benzodiazepine derivatives. The compounds according to the invention possess AMPA/kainate receptor inhibiting activity.Type: GrantFiled: July 29, 2004Date of Patent: June 14, 2011Assignee: Egis Gyogyszergyar Rt.Inventors: Jozsef Barkoczy, Istvan Ling, Gyula Simig, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szücs, Geza Szabo, Miklos Vegh, Laszlo Gabor Harsing
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Patent number: 7910591Abstract: The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favorable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system.Type: GrantFiled: May 11, 2005Date of Patent: March 22, 2011Assignee: EGIS Gyogyszergyar NYRT.Inventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsöfi, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szenasi, András Egyed, László Gábor Hársing
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Patent number: 7786129Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.Type: GrantFiled: May 11, 2005Date of Patent: August 31, 2010Assignee: Egis Gyogyszergyar NyrtInventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsöfi, Endréné Flórian, István Gacsályi, Katalin Pallagi, Gábor Gigler, György Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szénási, András Egyed, László Gábor Hársing
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Publication number: 20100190778Abstract: The present invention is related to new 3,4-dihydroberizo[1,2,3]thiadiazine-1,1-dioxide derivatives of the Formula (I), medicaments containing said new compounds, process for the preparation thereof and the use of said derivatives in the medicine. The compounds according to the present invention are suitable for the treatment or prevention of disorders of the central nervous system.Type: ApplicationFiled: August 13, 2007Publication date: July 29, 2010Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENTARSASAGInventors: Marta Porcs-Makkay, Gyula Lukacs, Gabor Kapus, Istvan Gacsalyi, Gyula Simig, Gyoergy Levay, Tibor Mezei, Miklos Vegh, Szabolcs Kertesz, Jozsef Barkoczy, Csilla Leveleki, Laszlo Gabor Harsing
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Publication number: 20100168087Abstract: The present invention relates to new benzo[1,2,3]thiadiazine-1,1-dioxide derivatives of the general Formula (I), medicaments containing such compounds and the use thereof in the medicine. Benzo[1,2,3]thiadiazine-1,1-dioxide derivatives of the general Formula (I) are suitable for the prevention or treatment of the diseases of the central nervous system.Type: ApplicationFiled: August 13, 2007Publication date: July 1, 2010Inventors: Marta Porcs-Makkay, Gyula Lukacs, Gabor Kapus, Istvan Gacsalyi, Gyula Simig, Gyoergy Levay, Tibor Mezei, Miklos Vegh, Szabolcs Kertesz, Jozsef Barkoczy, Csilla Leveleki, Laszlo Gabor Harsing
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Publication number: 20100075975Abstract: The invention relates the use of 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazole-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or pharmaceutically acceptable salts thereof for the preparation of medicaments suitable for the improvement of cognitive function or obtaining neuroprotective effect. The medicaments containing 4-chloro-5-{2-[4-(6-fluoro-1,2-benz[d]isoxazol-3-yl)piperidin-1-yl]ethyl-amino}-2-methyl-3-(2H) pyridazinone of the Formula (I) or therapeutically acceptable salt thereof can be used for the treatment or prevention of neuronal death, mental decline, sclerosis multiplex, Creuzfeld-Jacobs disease, Huntington-syndrome, amyotrophic lateral sclerosis, Parkinson-disease, memory disturbance, loss of memory, amnesia, stroke or for the improvement of memory function or learning ability.Type: ApplicationFiled: July 3, 2007Publication date: March 25, 2010Inventors: István Gacsalyi, Gábor Gigler, Márta Agoston, Hajnalka Kompagne, Szabolcs Kertesz, Krisztina Moricz, György Levay, Gábor Szenas, László Gábor Harsing, József Barcoczy, Gyula Simig
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Publication number: 20090281137Abstract: The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I) The new compounds are useful for the treatment or prophylaxis of the central nervous system, the gastrointestinal system or the cardiovascular system.Type: ApplicationFiled: July 9, 2009Publication date: November 12, 2009Inventors: Balázs Volk, József Barkóczy, Gyula Simig, Tibor Mezei, Rita Kapillerné Dezsófi, István Gacsályi, Katalin Pallagi, Gábor Gigler, Gyôrgy Lévay, Krisztina Móricz, Csilla Leveleki, Nóra Sziray, Gábor Szénási, András Egyed, László Gábor Hársing
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Publication number: 20090233913Abstract: The present invention relates to dihydro-2,3-benzodiazepine compounds of high enantiomeric purity according to the general formula (I), which contain an asymmetric centre at the position 4 of the dihydro-2,3-benzodiazepine compound, and the preparation thereof and the used intermediates as well. These compounds have anti-convulsiveA muscle relaxant and neuroprotective effect due their non-competitive AMPA antagonistic properties.Type: ApplicationFiled: December 29, 2006Publication date: September 17, 2009Inventors: Istvan Ling, Jozsef Barkoczy, Zoltan Greff, Gabor Szenasi, Gabor Gigler, Szabolcs Kertesz, Gyula Szucs, Mihaly Albert, Gabor Kapus, Geza Szabo, Miklos Vegh, Marta Agoston, Gyorgy Levay, Krisztina Moricz, Laszlo Gabor Harsing
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Publication number: 20080161323Abstract: The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favourable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system.Type: ApplicationFiled: May 11, 2005Publication date: July 3, 2008Applicant: EGIS GYOGYSZERGYAR RT.Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Gabor Harsing
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Patent number: 7317684Abstract: The present invention provides a method for optimizing elastic flows in a multi-path network for a traffic demand by jointly determining a bandwidth for each flow in a set of flows that realize the traffic demand and an optimized path for the traffic demand by maximizing a fairness utility. The present invention can be implemented as a computer program embodied on a computer readable medium in which the functions or steps of the method are implemented as code segments. In addition, the present invention can be implemented as an apparatus that includes a processor and an interface communicably coupling the processor to the multi-path network. The processor jointly determines a bandwidth for each flow in a set of flows that realize the traffic demand and an optimized path for the traffic demand by maximizing a fairness utility.Type: GrantFiled: August 28, 2002Date of Patent: January 8, 2008Assignee: Telefonaktiebolaget LM Ericsson (publ)Inventors: Gábor Fodor, Laszlo Gábor Malicskó, Michal Pióro
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Patent number: 7189711Abstract: The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a C1-4 alkyl group or a group of the formula —NR1R2, wherein R1 and R2 represent, independently, a hydrogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or a C3-6 cycloalkyl group.Type: GrantFiled: December 19, 2001Date of Patent: March 13, 2007Assignee: Egis Gyogyszergyar RT.Inventors: István Ling, József Barkóczy, Gyula Simig, Zoltán Greff, Zoltán Rátkai, Géza Szabó, Miklós Végh, Gábor Gigler, Gábor Szénási, Bernadett Martonné Markó, György Lévay, László Gábor Hársing
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Patent number: 7183283Abstract: The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds.Type: GrantFiled: December 28, 2002Date of Patent: February 27, 2007Assignee: Egis Gyogyszergyar RT.Inventors: József Barkóczy, István Gacsályi, László Gábor Hársing, Péter Kótay Nagy, György Lévay, Éva Schmidt, Gyula Simig
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Publication number: 20040171696Abstract: The compounds of the general Formula (I) (wherein R stands for hydrogen or methyl) can be used for the treatment or prophylaxis of diseases characterized either by the decline and/or damage of cognitive functions, or mental disability accompanying other diseases. As compound of the general Formula I preferably -(1R,2S,4R)-(−)-2-(2-dimethylaminoethoxy)-2-phenyl-1,7,7-trimethylbicyclo[2.2.1]heptane-fumarate can be used.Type: ApplicationFiled: April 15, 2004Publication date: September 2, 2004Inventors: Istvan Gacsalyi, Gyorgy Levay, Ildiko Nagyne Gyonos, Laszlo Gabor Harsing
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Publication number: 20030072327Abstract: The present invention provides a method for optimizing elastic flows in a multi-path network for a traffic demand by jointly determining a bandwidth for each flow in a set of flows that realize the traffic demand and an optimized path for the traffic demand by maximizing a fairness utility. The present invention can be implemented as a computer program embodied on a computer readable medium in which the functions or steps of the method are implemented as code segments. In addition, the present invention can be implemented as an apparatus that includes a processor and an interface communicably coupling the processor to the multi-path network. The processor jointly determines a bandwidth for each flow in a set of flows that realize the traffic demand and an optimized path for the traffic demand by maximizing a fairness utility.Type: ApplicationFiled: August 28, 2002Publication date: April 17, 2003Inventors: Gabor Fodor, Laszlo Gabor Malicsko, Michal Pioro
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Patent number: 4482494Abstract: The invention relates to a novel process for the preparations of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond beween the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.Type: GrantFiled: October 20, 1982Date of Patent: November 13, 1984Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Anna Boor, Jozsef Toth, Tamas Szen, Laszlo Gabor, Piroska Major nee Feistner, Sandor Holly
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Patent number: 4368160Abstract: The invention relates to a novel process for the preparation of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond between the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.Type: GrantFiled: April 2, 1982Date of Patent: January 11, 1983Assignee: Richter Gedeon Vegyeszeti Gyar R.T.Inventors: Anna Boor nee Mezei, Jozsef Toth, Tamas Szen, Laszlo Gabor, Piroska Major nee Fastner, Sandor Holly