Patents by Inventor Laszlo Harsing
Laszlo Harsing has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190109715Abstract: Provided is a method and system for producing message authentication tags and a method and system for producing hash values using bit-mixers. The methods include producing a message authentication or hash value by obtaining a message; segmenting, padding by an electronic processor, the message into a number of equal sized message blocks comprising a first message block, one or more subsequent message blocks, and a final message block; performing, by the electronic processor, a first bit-mixing operation on the first message block with an initialization value; performing, by the electronic processor, subsequent bit-mixing operations on the one or more subsequent message blocks and the final message block with a previous message block; and producing, by the electronic processor, the message authentication tag based on the first bit-mixing operation and the subsequent bit-mixing operations, employing a secret key material.Type: ApplicationFiled: October 6, 2017Publication date: April 11, 2019Inventor: Laszlo HARS
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Publication number: 20080021016Abstract: The invention relates to a combined pharmaceutical composition for the inhibition of the decline of cognitive functions comprising as A) component (1R,2S,4R)-(-)-2-[N,N-(dimethylaminoethoxy)]-2-phenyl-1,7,7-trimethylbicyclo]-2-phenyl-1.7.-trimethylbicyclo[2.2.1]heptane of the formula (I) or a pharmaceutically acceptable acid addition salt thereof and as B) component a nootropic, an inhibitor of the acetylcholinesterase enzyme and/or a further pharmaceutical active ingredient which exhibits a beneficial effect on the cognitive processes in admixture with suitable inert pharmaceutical carriers and/or auxiliary agents. The combined pharmaceutical composition according to the present invention can be particularly used for the treatment of Alzheimer disease or other diseases showing similar symptoms, diseases accompanied by malfunctions of intellectual abilities (e.g.Type: ApplicationFiled: March 12, 2004Publication date: January 24, 2008Inventors: Gyorgy Levay, Istvan Gacsalyi, Laszlo Harsing, Gyula Simig
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Publication number: 20070265300Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I). Compounds according to the invention are useful for the prophylaxis or treatment of the disorders of the central nervous system.Type: ApplicationFiled: May 10, 2005Publication date: November 15, 2007Applicant: Egis gyogyszergyar rt.Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Harsing
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Publication number: 20070244102Abstract: The invention relates to a combined analgesic pharmaceutical composition which comprises as component: A) (1R,2S,4R)-(?)-2-[N,N-(dimethylaminoethoxy)]-2-phenyl-1,7-7-trimethylbicyclo[2.2.1]heptane or a pharmaceutically acceptable acid addition salt thereof and as component B) morphine, an opioide type analgesic and/or a non-opioide type analgesic in admixture with suitable pharmaceutical carriers and/or auxiliary agents. Deramciclane increases the analgesic effect of morphine.Type: ApplicationFiled: March 12, 2004Publication date: October 18, 2007Inventors: Istvan Gacsalyi, Gabor Gigler, Laszlo Harsing, Gyorgy Levay, Gabor Szenasi
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Publication number: 20070232619Abstract: The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.Type: ApplicationFiled: May 11, 2005Publication date: October 4, 2007Applicant: EGIS GYOGYSZERGYAR RT.Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Dezsofi, Endrene Florian, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasl, Andras Egyed, Laszlo Harsing
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Publication number: 20070232662Abstract: The present invention is related to new 3,3-disubstituted indol-2-one derivatives of the general Formula (I). The new compounds are useful for the treatment or prophylaxis of the central nervous system, the gastrointestinal system or the cardiovascular system.Type: ApplicationFiled: May 11, 2005Publication date: October 4, 2007Applicant: Egis Gyogyszergyar RT.Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Harsing
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Publication number: 20070219209Abstract: The present invention is concerned with new indol-2-one derivatives of the general Formula (I). The new compounds are useful for the treatment or prevention of the disorders of the central nervous system or the cardiovascular system.Type: ApplicationFiled: May 10, 2005Publication date: September 20, 2007Applicant: GYÓGYSZERGYÁR RT.Inventors: Balazs Volk, Jozsef Barkoczy, Gyula Simig, Tibor Mezei, Rita Kapillerne Dezsofi, Istvan Gacsalyi, Katalin Pallagi, Gabor Gigler, Gyorgy Levay, Krisztina Moricz, Csilla Leveleki, Nora Sziray, Gabor Szenasi, Andras Egyed, Laszlo Harsing
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Publication number: 20060211703Abstract: The compounds of the general Formula I, wherein R1 stands for hydrogen or lower alkyl; one of symbols X and Y stands for hydrogen or halogen and the other represents a group of the general Formula II, R2 is hydrogen or lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or aryl-lower alkyl; Z is -0-; or R3 and Z together with the intermediate atoms form piperazino ring; Q and W independently from each other stands for —CH? or —N?; and R4, R5 and R6 can be the same or different and stand for hydrogen, halogen, trifluoromethyl or lower alkoxy; or R4 and R5 together form an ethylenedioxy group) and pharmaceutically acceptable salts thereof can be used for the treatment or prophylaxis of malfunctions of memory and/or cognitive decline or prevention of decline of learning abilities.Type: ApplicationFiled: November 13, 2003Publication date: September 21, 2006Inventors: Gyorgy Levay, Istvan Gacsalyi, Bernadett Marko, Eva Schmidt, Andras Egyed, Hajnalka Kompagne, Csilla Leveleki, Aniko Miklosne Koivacs, Gabor Szenasi, Janos Wellmann, Laszlo Harsing, Jozsef Barkoczy, Gyula Simig, Peter Kotay Nagy
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Publication number: 20050215560Abstract: The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C1-4-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety.Type: ApplicationFiled: December 28, 2002Publication date: September 29, 2005Inventors: Jozsef Barkoczy, Istvan Gacsalyi, Laszlo Harsing, Peter Kotay Nagy, Gyorgy Levay, Iva Schmidt
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Publication number: 20050043314Abstract: New substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; X is hydrogen or halogen; R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Q and W independently from each other stand for —N? or —CH?; and R4 and R5 independently from each other represent hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof possess useful anxiolytic and cognition enhancing properties.Type: ApplicationFiled: September 26, 2002Publication date: February 24, 2005Inventors: Jozsef Barkoczy, Andras Egyed, Istvan Gacsalyi, Laszlo Harsing, Hajnalka Kompagne, Peter Kotay Nagy, Gyorgy Levay, Csilla Leveleki, Bernadett Martonne Marko, Aniko Miklosne Kovacs, Eva Schmidt, Gyula Simig, Gabor Szenasi, Janos Wellmann
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Publication number: 20040242873Abstract: The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.Type: ApplicationFiled: June 28, 2004Publication date: December 2, 2004Inventors: Jozsef Barkoczy, Andras Egyed, Istvan Gacsalyi, Laszlo Harsing, Hajnalka Kompagne, Peter Kotay Nagy, Gyorgy Levay, Csilla Leveleki, Bernadett Martonne Marko, Aniko Miklosne Kovacs, Eva Schmidt, Gyula Simig, Gabor Szenasi, Janos Wellmann
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Patent number: 6602865Abstract: Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.Type: GrantFiled: November 15, 1999Date of Patent: August 5, 2003Assignee: IVAX Drug Research Institute, Ltd.Inventors: Ferenc Andrasi, Agnes Angyal nee Pataky, Pal Berzsenyi, Sandor Boros, Laszlo Harsing, Katalin Horvath, Peter Matyus, Imre Moravcsik, Agnes Papp nee Behr, Antal Simay, Erzsebet Szabo nee Bagdy, Katalin Szabo nee Pusztai, Istvan Tarnawa, Ildiko Varga
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Patent number: 4940716Abstract: Diuretic and saluretic tetrahydro-isoquinoline derivatives of the Formula (I) ##STR1## wherein R stands for hydrogen or chlorine,R.sup.1 and R.sup.2 are hydrogen, methoxy or ethoxy, andR.sup.3 and R.sup.4 are hydrogen or methyl,and a process for the preparation thereof as well as pharmaceutical compositions containing as active ingredients isoquinoline derivatives of the Formula (I). The compounds of Formula I are prepared by reacting a 2-amino-tetrahydro-isoquinoline derivative of the Formula (II) ##STR2## with a carboxylic acid derivative of the Formula (III) ##STR3## wherein x stands for chlorine, --OH, --OCH.sub.2 CN, --OCH.sub.3, --OC.sub.2 H.sub.5, --OCOOCH.sub.3 or --OCOOC.sub.2 H.sub.5R.sup.5 and R.sup.6 stand for hydrogen or together from CHN(CH.sub.3).sub.2 and in case of the Formula (Ia) ##STR4## splitting off the protective group in alkaline medium.Type: GrantFiled: December 29, 1988Date of Patent: July 10, 1990Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szyoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Vera Gergely, Peter Kormoczi, Katalin Marmarosi nee Keliner, Sandor Virag
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Patent number: 4916149Abstract: The present invention relates to novel compounds of the general formula ##STR1## wherein R is hydrogen atom or a trifluoromethyl, carboxy, C.sub.2-5 alkoxycarbonyl, cyano, benzoyl, sulfamoyl or C.sub.1-4 alkylsulfonyl group;R.sup.1 is hydrogen atom or a linear or branched chain C.sub.1-4 alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulfonyl, benzylthio, benzylsulfonyl, phenyl, hydroxy or mercapto group; andR.sup.2 is hydrogen or chlorine atom,as well as their pharmaceutically acceptable salts.The compounds according to the invention possess diuretic and saluretic activity with an advantageous Na/K ratio.Type: GrantFiled: December 29, 1988Date of Patent: April 10, 1990Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Endre Palosi, Dezso Korbonits, Erzsebet Molnar nee Bako, Ida Szoboda nee Kanzel, Laszlo Harsing, Gyorgy Simon, Sandor Virag, Vera Gergely, Katalin Marmarosi nee Kellner
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Patent number: 4851416Abstract: The invention relates to novel racemic or optically active berban derivatives of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent independently from the other a hydroxyl, straight or branched chain alkoxy group 1 to 6 carbon atoms or R.sup.1 and R.sup.2 together represent a C.sub.1-3 alkylenedioxy group;R.sup.3 and R.sup.4 represent independently from the other hydrogen, straight or branched chain alkyl group, having 1 to 6 carbon atoms and optionally substituted by hydroxyl group, or a C.sub.2-6 alkoxycarbonyl or cyano group; andR.sup.5 represents hydrogen, straight or branched chain alkyl group having 1 to 6 carbon atoms, C.sub.1-7 aliphatic or aromatic acyl group or C.sub.1-7 alkylsulphonyl or arylsulphonyl group, anda salt thereof, to pharmaceutical compositions containing them, to the use as well as to process for preparing the novel compounds. The compounds of the formula (I) are selective .alpha..sub.Type: GrantFiled: May 23, 1986Date of Patent: July 25, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Szilveszter Vizi, Csaba Szantai, Lajos Szabo, Istvan Toth, Gabor Kovacs, Jeno Marton, Laszlo Harsing, Gyorgy Somogyi, Jozsef Gaal