Abstract: The invention relates to novel partially methylated carboxyacyl-cyclodextrins of the general formula (I), ##STR1## wherein A means the cyclodextrin skeleton of the general formula (II) ##STR2## containing the substituents in the position labelled by the wavy line; W stands for an alkylene, alkenylene or arylene group or the substituted derivatives thereof;R means hydrogen, an alkyl, aryl or aralkyl group;m is 6, 7 or 8;n is an integer from 1 to 2m; andp is 2m-n+z, wherein the value of z is from 0 to 3as well as their salts.The novel derivatives induce less haemolytic effect than the cyclodextrin compounds used as starting materials.

Abstract: The invention relates to new hexitols having the general formula (I) and (II), ##STR1## wherein the hexitol skeleton is dulcitol, mannitol or iditol,X represents halogen, preferably bromine,R is a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, andR.sup.1 is hydrogen, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains a free carboxy group, a saturated or unsaturated C.sub.2-10 alkylcarbonyl group, a saturated or unsaturated C.sub.4-10 alkylcarbonyl group which also contains an alkoxycarbonyl group, or a saturated or unsaturated C.sub.8-10 aralkylcarbonyl group,and salts of these compounds. The new compounds according to the invention have tumor-inhibiting affects.The above compounds are prepared according to the invention so that(a) a compound of the general formula (IX), whereinthe hexitol skeleton is dulcitol, mannitol or iditol,Q is a saturated or unsaturated C.sub.

Abstract: The invention relates to novel anticarcinogenic compounds of formula I, ##STR1## wherein R.sup.1 is halogenR.sup.2 is hydroxy orR.sup.1 and R.sup.2 together form an oxygen bridge,R.sup.3 is methyl,R.sup.4 is hydrogen, methyl or acyl,n is 1 or zero, with the provisos, that in case n is 1 the steric positions of --R.sup.2, OR.sup.3 and --OR.sup.4 groups correspond to dulcitol, mannitol or sorbitol configurations independently of their actual meanings, in case n is zero the steric positions of --R.sup.2 and --OR.sup.3 groups correspond to xylitol configuration independently of their actual meanings.The novel compounds can be used as antitumor agents in themselves or formulated as pharmaceutical preparations.

Abstract: New compounds and a process for making the same, for use in inhibiting aggregation in human blood and inhibiting the growth of tumors, said compounds being of the general formula: ##STR1## wherein R is hydrogen, alkanoyl, substituted alkanoyl, aralkanoyl or aroyl and represents .alpha. or .beta. steric position or .alpha. and .beta. position, with the provision that if R stands for p-phenyl-benzoyl then methoxy in the position 2 may stand only in .alpha. or only in .beta. steric position.

Abstract: Racemic or optically active compounds with antitumor activity of the formula: ##STR1## wherein X is oxygen or sulfur;R.sup.1 is hydrogen, C.sub.1 to C.sub.4 alkanoyl, benzoyl or phenyl-substituted benzoyl;R.sup.2 is hydrogen or C.sub.1 to C.sub.4 alkanoyl;R.sup.3 is C.sub.2 to C.sub.40 straight or branched chain alkyl substituted by hydroxy, epoxy, amino, C.sub.1 to C.sub.6 alkylamino, C.sub.1 to C.sub.6 dialkylamino, C.sub.1 to C.sub.6 alkanoyloxy or, C.sub.1 to C.sub.4 alkoxycarbonyl; cyclohexyl, phenyl unsubstituted or substituted by halogen, amino, C.sub.1 to C.sub.4 alkyl-substituted amino, C.sub.1 to C.sub.4 alkoxy, nitro, or hydroxy; C.sub.1 to C.sub.6 alkanoyl; allyl or phenyl-C.sub.1 to C.sub.4 alkyl unsubstituted or substituted by a C.sub.2 to C.sub.6 alkene group; or where X is sulfur R.sup.3 is as defined above or is C.sub.1 to C.sub.40 straight or branched chain alkyl; and.about. represents the exo- or endo-steric position in the ring and indicates an .alpha.- or .beta.

Abstract: A compound selected from the group which consists of the amidine of formula ##STR1## and the phytotoxically acceptable addition salts, hemihydrates and hydrates thereof,R.sup.1, r.sup.2 and R.sup.3 being phenyl or a phenyl group substituted with chlorine, bromine, iodine or fluorine, alkoxy having 1-4 carbon atoms or alkyl having 1 to 4 carbon atoms,R.sup.4 being methyl.

Abstract: This invention is directed to the preparation of a cytostatic sugar derivative, 1,6-dibromo-1,6-dideoxy-dulcitol and of pharmaceutical compositions containing same.