Abstract: The invention relates to methods for screening selective modulators of half transporter proteins of the ABCG family, more closely of ABCG1 and ABCG4. In particular the invention relates to methods for determining whether a substance is a selective activator, an inhibitor or a substrate of an ABCG1 or ABCG4 homodimer or of an ABCG1/ABCG4 heterodimer protein, methods for detection of ABCG1 protein in a biological sample, methods for modulating the function of said proteins, and methods for detecting the presence of and/or quantitating ABCG1/ABCG4 heterodimer activity in a biological sample. Moreover, the invention relates to isolated ABCG1/ABCG4 heterodimer proteins and antibodies selective for ABCG1 or ABCG4. The closely related human ABC half-transporters, ABCG1 and ABCG4, have been suggested to play an important role in cellular lipid/sterol regulation. ABCG1 and ABCG4 and mutants thereof have been expressed and studied by the present inventors in whole cells as well as isolated membrane preparations.

Abstract: An apparatus for indicating and controlling the vehicle speed and load of a mobile foliage chopping machine. As rotational speed of the chopping drum increases over its permissible minimum, a vehicle increasing speed control is carried out. Correspondingly, a decrease in speed due to increase in the working load of the chopping drum is compensated by a reduction of gear transmission of the driving machinery. Thus, the adjusted speed is held but in case of chopping drum overload, when rotational speed of the drum starts to fall below the permissible minimum, the vehicle speed control is discontinued, i.e., a speed decreasing intervention is done, therefore the permissible working load of chopping machine is held, while overload is avoided.