Patents by Inventor Laszlo Szlavik

Laszlo Szlavik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR THE PRODUCTION OF LUMATEPERONE AND ITS SALTS
    Publication number: 20230331727
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X = I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Application
    Filed: February 16, 2023
    Publication date: October 19, 2023
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ
  • Method for the production of lumateperone and its salts
    Patent number: 11655251
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: May 23, 2023
    Assignee: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor Berecz, Bálint Nyulasi, Mátyás Milen, Gyula Simig, András Mravik, Gábor Németh, Adrienn Keszthelyi, Beatrix Bali, Balázs Volk, László Szlávik, Zoltán Varga, Daniel Ulej
  • METHOD FOR THE PRODUCTION OF LUMATEPERONE AND ITS SALTS
    Publication number: 20210070755
    Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X?I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.
    Type: Application
    Filed: November 27, 2018
    Publication date: March 11, 2021
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Gábor BERECZ, Bálint NYULASI, Mátyás MILEN, Gyula SIMIG, András MRAVIK, Gábor NÉMETH, Adrienn KESZTHELYI, Beatrix BALI, Balázs VOLK, László SZLÁVIK, Zoltán VARGA, Daniel ULEJ
  • PROCESS FOR THE PRODUCTION OF OZANIMOD
    Publication number: 20200087269
    Abstract: The present invention relates a new process for the preparation of ozanimod of the formula and acid addition salts, via new intermediates and a new polimop form of ozanimod base.
    Type: Application
    Filed: May 18, 2018
    Publication date: March 19, 2020
    Applicant: EGIS GYOGYSZERGYAR ZRT.
    Inventors: Marta PORCS-MAKKAY, Gyula SIMIG, Eniko MOLNAR, Janos PETHO, Balazs VOLK, Laszlo SZLAVIK, Eva SZABO, Judit HALASZ
  • Pharmaceutical intermediates and process for the preparation thereof
    Patent number: 9260421
    Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: February 16, 2016
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
  • Method for purifying diatomaceous earth
    Patent number: 8883860
    Abstract: A method for purifying diatomaceous earth, whose natural colloidal structure is retained, which includes preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: November 11, 2014
    Assignees: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, ONP Holdings SE
    Inventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
  • PHARMACEUTICAL INTERMEDIATES AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20140155614
    Abstract: The present invention relates to a process for the preparation of dabigatran etexilate of the formula or pharmaceutically accepted salts thereof.
    Type: Application
    Filed: May 10, 2012
    Publication date: June 5, 2014
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Imre Kiraly, Tibor Szabo, Gyula Simig, Balazs Volk, Laszlo Szlavik, Jozsef Barkoczy, Gyorgy Ruzsics, Gyula Lukacs, Laszlo Pongo, Andras Boza, Maria Tothne Lauritz, Maria Kovacs
  • METHOD FOR PREPARATION OF AN EXCIPIENT SUITABLE FOR PHARMACEUTICAL USE
    Publication number: 20130225695
    Abstract: The present invention is related to a method for purifying diatomaceous earth wherein the natural colloidal structure of the material is retained, which comprises preparing a suspension of diatomaceous earth in a liquid wherein diatomaceous earth is insoluble, separating diatomaceous earth from the suspension, treating diatomaceous earth with an inorganic or organic acid, heat-treating the thus obtained product at a temperature not higher than 300° C., subjecting the product obtained to oxidative treatment and drying the purified product. The invention also relates to a product obtainable by the above-mentioned method.
    Type: Application
    Filed: October 12, 2011
    Publication date: August 29, 2013
    Applicants: ONP HOLDINGS SE, EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Endre Mikulásik, Tamás Spaits, Kálmán Nagy, Gyula Lukács, Imre Markovits, Krisztina Fodorné Kocsmár, Livia Gregorné Boros, Tamás Mórász, László Szlávik, Máté Hudák, Gyöngyi Heréb, Réka Eszter Puskás, Zoltán Varga, Imre Kapui, György Clementis, Gábor Attila Bacher, Beatrix Bánkövi, Gitta Kiss, Ottó Albrecht
  • Pharmaceutical composition having synergistic analgesic activity
    Patent number: 3954986
    Abstract: An analgesic substitute for morphine comprising the synergistic combination of azidomorphine or azidocodeine with a pyrimidazolium.
    Type: Grant
    Filed: November 14, 1973
    Date of Patent: May 4, 1976
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.
    Inventors: Jozsef Knoll, Zsuzsanna Furst, Zoltan Meszaros, Peter Szentmiklosi, Agoston David, Istvan Hermecz, Attila Mandi, Rezso Bognar, Sandor Makleit, Gyula Valovics, Laszlo Szlavik, Sandor Nagy