Patents by Inventor Laszlo Szporny

Laszlo Szporny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6656921
    Abstract: The invention relates to pharmaceutical compositions against peptic ulcer as well as to a method of treating peptic ulcer. The compositions contain and the method of treatment employs zinc hyaluronate as an active ingredient having a molecular weight in the range of 500,000 to 1,200,000 daltons.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 2, 2003
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Janos Illes, Judit Matuz, Erzsabet Neszmelyi, Gaborne Forrai, Bela Stefko, Katalin Saghy, Laszlo Szporny
  • Patent number: 5589486
    Abstract: The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula ##STR1## wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that:m is 0 or 2, or both G and I are hydrogen, when A is benzyl or halogen-monosubstituted benzyl group; andm is 1, when A is 2-picolyl, as well as their pharmaceutically acceptable acid addition salts. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic results.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: December 31, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Kalman Harsanyi, Tibor Gizur, Eva Agai-Csongor, Anna Kallai-Sohonyai, Marta Kapolnas-Pap, Eva Csizer, Bela Heged us, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo, Peter Bod, Attila Csehi
  • Patent number: 5547949
    Abstract: Novel, therapeutically active 21-aminosteroids of formula (I) ##STR1## with pregnane skeleton, are disclosed wherein two of X, Y and Z are a nitrogen atom each and the third one is a methine group; R.sup.1 and R.sup.2 are independently from each other, a primary amino group bearing as substituent a branched-chain C.sub.4-8 alkyl -alkenyl or -alkynyl group, or a C.sub.4-10 cycloalkyl group comprising 1 to 3 ring(s) and being optionally substituted by at least one C.sub.1-3 alkyl group; or R.sup.1 and R.sup.2 are each a spiro-heterocyclic secondary amino group containing at most 10 carbon atoms and optionally at least one oxygen atom as additional heteroatom; or one of R.sup.1 and R.sup.2 is an unsubstituted heterocyclic secondary amino group containing 4 to 7 carbon atoms and the other one is an above-identified primary amino group, an above-identified spiro-heterocyclic secondary amino group, or a heterocyclic secondary amino group containing 4 to 7 carbon atoms and substituted by at least one C.sub.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: August 20, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Sandor Maho, Zoltan Tuba, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Erzsebet C. Francsicsne, Anna M. Boorne, Gabor Balogh, Sandor Gorog
  • Patent number: 5510345
    Abstract: The invention relates to novel eburnamenine derivatives of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 as well as R.sup.3 and R.sup.4, independently from each other, stand for hydrogen, C.sub.2-6 alkyl group, C.sub.2-6 alkenyl group; or a C.sub.3-10 alicyclic group involving 1 to 3 rings, and this latter group may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4, together with the adjacent nitrogen atom and optionally with an additional oxygen or nitrogen atom, form a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C.sub.1-6 alkyl or C.sub.2-6 alkenyl group; two of X, Y and Z are nitrogen whereas the third of them means a methine group; n is 1 or 2; W means oxygen or two hydrogen atoms; and the wavy line means .alpha.-/.alpha.-, .alpha.-/.beta.- or .beta.-/.alpha.- steric position, as well as their acid addition salts and solvates.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: April 23, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Zoltan Tuba, Sandor Maho, Aniko Gere, Pal Vittay, Bela Kiss, Eva Palosi, Laszlo Szporny, Csaba Szantay, Ferenc Soti, Zsuzsa Baloghne Kardos, Maria Incze, Gabor Balogh, Maria Gazdag
  • Patent number: 5494909
    Abstract: New compounds with the ability to inhibit calcium uptake in the brains of mammals are disclosed of the Formula (I) ##STR1## wherein R.sup.1 is hydrogen, C.sub.1 to C.sub.4 alkyl, phenyl, or phenyl-C.sub.1 to C.sub.4 alkyl;one of R.sup.2 and R.sup.3 is C.sub.1 to C.sub.4 alkoxy and the other one is phenyl-C.sub.1 to C.sub.4 alkoxy optionally substituted by C.sub.1 to C.sub.4 alkyl in the aromatic nucleus; andR.sup.4 is phenyl optionally substituted by C.sub.1 to C.sub.4 alkyl in the aromatic nucleus, or their solvates, individual optically active and geometric isomers, mixtures of such isomers, as well as pharmaceutically acceptable acid addition salts thereof. The compounds of the Formula (I) are capable of inhibiting calcium uptake to brain cells and have a protective effect on hypobaric hypoxia.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: February 27, 1996
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Jen Kobor, Laszlo Lazar, Imre Huber, Judit Arva, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo, Gabor Bernath, Ferenc Fulop
  • Patent number: 5340823
    Abstract: A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the treatment, a therapeutically effective amount of a compound of the Formula (I) ##STR1## wherein m is 1,2 or 3;R.sub.1 and R.sub.2 each independently stand for hydrogen, C.sub.1 to C.sub.4 straight or branched chain alkyl, C.sub.1 to C.sub.4 alkoxy, C.sub.5 to C.sub.7 cycloalkyl, or halogen; andB is a 5- or 6-membered saturated or unsaturated heterocyclic group containing a nitrogen heteroatom, the heterocyclic group being bound through its heterocyclic nitrogen atom to the remainder of the compound, and which can contain one or two additional heteroatoms selected from the group consisting of an oxygen heteroatom, a sulfur heteroatom, and one or two additional nitrogen heteroatoms, which may be as an .dbd.N--, --NH-- or --NR-- group, where R is a C.sub.1 to C.sub.5 alkyl or C.sub.1 to C.sub.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: August 23, 1994
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Sandor Farkas, Sandor Foldeak, Egon Karpati, Peter Hegyes, Janos Kreidl, Laszlo Szporny, Laszlo Czibula, Szilvia Petofi-Vass
  • Patent number: 5273960
    Abstract: The present invention relates to a process for the preparation of high purity crystalline peptides Arg Lys Asp hydrate acetate and Arg Lys Asp Val from crude, amorphous peptides Arg Lys Asp and Arg Lys Asp Val hydrate acetate.The process is characterized in thatthe crude, amorphous peptide Arg Lys Asp or Arg Lys Asp Val is let stand at room temperature in 5 to 20 unit volume of ethanol containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml,then the crystallized peptide is separated from the crystalline suspension, preferably after cooling.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: December 28, 1993
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Olga Nyeki, Istvan Schon, Laszlo Denes, Gyorgy Hajos, Laszlo Szporny, Geza Ivanyi, Tamas berhardt, Lajos Kovacs, Imre Peter, Maria Gazdag, Zsuzsanna Muck, Iidiko berhardt, Gizella Lorant
  • Patent number: 5225416
    Abstract: The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) ##STR1## wherein R stands for hydrogen or an alkyl group,X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,Y stands for hydrogen or halogen or a trifluoro-methyl groupas well as enantiomers acid addition salts thereof.The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity.
    Type: Grant
    Filed: December 10, 1991
    Date of Patent: July 6, 1993
    Assignee: Richter Gedeon Vegyeszeti Termekek Gyara Rt.
    Inventors: Tibor Gizur, Kalman Harsanyi, Attila Csehi, Aniko Demeter nee Szabo, Ferenc Trischler, Eva Vajda, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Mihaly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmai, Erzsebet Lapis, Sandor Szabo
  • Patent number: 5214045
    Abstract: Novel acrylic amide derivatives of the Formula (I) ##STR1## wherein R.sup.1 represents a hydrogen or a halogen atom or a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group.n is an integer of 0 to 2,A represents an amino acid residue derived from a naturally occurring amino acid or an antipode thereof which is bonded to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid, bonded to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C.sub.1-4 alkyl group or is amidated; or A represents a group of the formula ##STR2## wherein R.sub.2 is a hydrogen atom or a phenyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxycarbonyl group,and their salts which have cytoprotective and antiulcer to activities. A process is also described for the preparation of said compounds.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: May 25, 1993
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tamas Fodor, Janos Fischer, Laszlo Dobay, Elemer Ezer, Judit Matuz, Laszlo Szporny, Gyorgy Hajos
  • Patent number: 5204355
    Abstract: The invention relates to novel 15-nitro-2.beta.,3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R.sup.1 stands for hydrogen;R.sup.2 stands for hydrogen or a C.sub.1-6 alkyl group; and the symbolrepresents a single or double bond as well as their salts.The invention further relates to pharmaceutical compositions containing the above compounds as well as a process for the preparation of the above compounds of formula (I) and of the pharmaceutical compositions.The compounds of formula (I) exert a reducing or inhibitory effect on cerebral edema and show antihypoxic properties. Thus, they are useful for the prevention or treatment of brain injuries of various origin induced by hypoxia of the brain.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: April 20, 1993
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Bela Zsadon, Margit Barta n/e/ e Bukovecz, Maria Szilasi, Tibor Keve, Janos Galambos, Viktoria Bolya nee Kassay, Sandor Szabo, Emilia Repasi, nee Balogh, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Zsolt Szombathelyi, Adam Sarkadi, Erzsebet Lapis, Aniko Gere, Mih,acu/a/ ly Bodo, Katalin Csomor, Judit Laszy, Zsolt Szentirmay
  • Patent number: 5198446
    Abstract: A method of treating a mammalian subject for Parkinson's disease or to provide a central muscle relaxant effect, which comprises the step of administering to the mammalian subject in need of the treatment, a therapeutically effective amount of a compound of the Formula (I) ##STR1## wherein m is 1,2 or 3;R.sub.1 and R.sub.2 each independently stand for hydrogen, C.sub.1 to C.sub.4 straight or branched chain alkyl, C.sub.1 to C.sub.4 alkoxy, C.sub.5 to C.sub.7 cycloalkyl, or halogen; andB is a 5- or 6-membered saturated or unsaturated heterocyclic group containing a nitrogen heteroatom, the heterocyclic group being bound through its heterocyclic nitrogen atom to the remainder of the compound, and which can contain one or two additional heteroatoms selected form the group consisting of an oxygen heteroatom, a sulfur heteroatom, and one or two additional nitrogen heteroatoms, which may be as an .dbd.N--, --NH-- or --NR-- group, where R is a C.sub.1 to C.sub.5 alkyl or C.sub.1 to C.sub.
    Type: Grant
    Filed: July 29, 1991
    Date of Patent: March 30, 1993
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Sandor Farkas, Sandor Foldeak, Egon Karpati, Peter Hegyes, Janos Kreidl, Laszlo Szporny, Laszlo Czibula, Szilvia Petofi-Vass
  • Patent number: 5162359
    Abstract: Novel antihyperlipoproteinemic compounds are disclosed of the formula I, ##STR1## wherein X is a halogen atom, methyl, ethyl, methoxy or ethoxy group,Y is hydroxy if X is methoxy or ethoxy, otherwise it is a hydrogen atom or a, methoxy or ethoxy group,Z is a methoxy or ethoxy group if X or Y is a methoxy group or an ethoxy group; otherwise it is hydrogen atom,The invention also covers antiartheriosclerotic, antihyperlipoproteinemic pharmaceutical compositions, suitable for inhibiting the formation of thrombuses, comprising the compounds of formula I in an effective dose, a process for preparing the same and methods for the treatment of hyperlipoproteinemia with the aid of the said compounds or compositions.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: November 10, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Kalman Harsanyi, Peter Tetenyi, Tamas Nagy, Attila Csehi, Tibor Gizur, Bela Hegedus, Andrea Maderspach, Andras Javor, Gyorgy Hajos, Laszlo Szporny
  • Patent number: 5157038
    Abstract: The invention relates to novel 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives of the formula (I), ##STR1## wherein X means oxygen or an >NR group, whereinR stands for hydrogen; a C.sub.1-12 alkyl; C.sub.3-6 cycloalkyl; carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the two latter two substituents optionally substituted on their aromatic moiety by one or more, same or different halogen, one or more C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trihalomethyl group; or a tosyl group;R.sup.1 and R.sup.2 together represent a methylene group or, when X stands for an >NR group wherein R is as defined above, one of R.sup.1 and R.sup.2 m may represent a hydroxyl group and the other one is a methyl group; andR.sup.3 means hydrogen, benzyl, (C.sub.1-4 alkoxy)carbonyl, phenoxycarbonyl, benzyloxycarbonyl, formyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, 4-(2-hydroxethyl)piperazin-1-ylcarbonyl, 2-chloro-3-nicotinoylcarbamoyl or C.sub.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: October 20, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Bela Hegedus, Laszlo Szporny, Bela Kiss, Eva Palosi, Dora Groo, Istvan Laszlovszky, Erzsebet Lapis, Ferenc Auth, Laszlo Gaal
  • Patent number: 5155123
    Abstract: The invention relates to novel pyridine derivatives of formula (I), ##STR1## wherein Q stand for a nitro or cyano group; andX.sup.1 and X.sup.2, independently from each other, represent hydrogen or halogen or a trifluoromethyl, a lower alkyl or alkoxy or nitro group bound to any of the carbon atoms of the phenyl ring.The invention further relates to pharmaceutical compositions containing these compounds and a process for their preparation.The compounds of formula (I) possess gastric acid secretion inhibiting, tissue-protecting, analgetic and mild antiinflammatory effects and are useful for therapeutical purposes.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: October 13, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Gyorgy Domany, Elemer Ezer, Istvan Schon, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Marta Renyei
  • Patent number: 5132303
    Abstract: The invention relates to novel, therapeutically active 4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives of the compound, ##STR1## wherein X means oxygen or an >NR group, whereinR stands for hydrogen, C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 arylC.sub.1-4 alkyl group, the latter two being optionally substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl group(s) or by one or more C.sub.1-4 alkoxy group(s);R.sup.3 and R.sup.4, which are the same or different, represent hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl group or hydroxyl group optionally esterified by a C.sub.1-4 alkanoic acid; andis 1 or 2,their isomers, solvates, hydrates, acid addition and quaternary ammonium salts.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: July 21, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Bela Kiss, Eva Palosi, Dora Groo, Istvan Laszlovszky, Erzsebet Lapis, Ferenc Auth, Laszlo Gaal
  • Patent number: 5132309
    Abstract: The invention relates to, therapeutically active 2-oxo-3,8-diazaspiro[4,5]decane derivatives (I), ##STR1## wherein R means hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two optionally being substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);one of R.sup.1 and R.sup.2 stands for a hydroxyl group whereas the other means a methyl gorup;R.sup.3 and R.sup.4, which are the same or different, represent hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl group or a hydroxyl group optionally esterified by a C.sub.1-4 alkanoic acid; andn is 1 or 2,their isomers, solvates, hydrates, acid addition and quaternary ammonium salts.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: July 21, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Edit Toth, Jozsef Torley, Sandor Gorog, Laszlo Szporny, Bela Kiss, Eva Palosi, Dora Groo, Istvan Laszlovszky, Erzsebet Lapis, Ferenc Auth, Laszlo Haal
  • Patent number: 5118687
    Abstract: The invention relates to novel compounds 1-oxa-2-oxo-8- of the formula (I), ##STR1## wherein X means oxygen or an >NR group, whereinR stands for hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.10-4 alkyl group, the latter two groups are optionally substituted on their aromatic moiety by one or more, same or different halogen(s), one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);R.sup.1 and R.sup.2 together represent a methylene group or, when X stands for an >NR group, wherein R is as defined above, one of R.sup.1 and R.sup.2 may represent a hydroxyl group whereas the other is a methyl group;R.sup.3 stands for hydrogen or a phenyl group optionally substituted by one or more halogen(s), one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy or hydroxyl group(s);R.sup.4 means hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: June 2, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Laszlo Szporny, Bela Kiss, Egon Karpati, Eva Palosi, Dora Groo, Istvan Laszlovszky, Zsolt Szombathelyi, Adam Sarkadi, Aniko Gere, Katalin Csomor, Mihaly Bodo, Judit Laszy, Zsolt Szentirmay
  • Patent number: 5118693
    Abstract: The invention relates to novel, therapeutically active 4,4-disubstituted piperidine derivatives of the formula (I), ##STR1## wherein R.sup.1 means hydrogen or --CONHR group, whereinR stands for hydrogen, C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two being optionally substituted on their aromatic moiety by one or more, same or different halogen(s) or one of more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);R.sup.2 stands for an ethynyl or acetyl group;R.sup.3 and R.sup.4, which are the same or different, represent hydrogen, one or more halogen(s), C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trihalomethyl group or hydroxyl group optionally esterified by a C.sub.1-4 alkanoic acid; andn is 1 or 2,as well as their pharmaceutically acceptable acid addition and quaternary ammonium salts.
    Type: Grant
    Filed: August 10, 1990
    Date of Patent: June 2, 1992
    Assignee: Richter Gedeon Vlcyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozef Torley, Sandor Gorog, Laszlo Szporny, Bela Kiss, Eva Palosi, Groo, Istvan Laszlovszky, Erzsebet Lapis, Ferenc Auth, Laszlo Gaal
  • Patent number: 5112815
    Abstract: The invention relates to novel 9.alpha.-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives of the formula (I), ##STR1## wherein M stands for hydrogen, C.sub.1-4 alkyl or a pharmaceutically accteptable cation to a process for repairing these compounds and to compositions containing said compounds which exert an anti-hypercholesteremic effect.
    Type: Grant
    Filed: February 17, 1991
    Date of Patent: May 12, 1992
    Assignee: Richer Gedeon Vegyeszet
    Inventors: Gabor Ambrus, Andrea Maderspach, Antalne Jekkel, Andras Javor, Eva Ilkoy, Gyorgy Hajos, Laszlo Szporny, Jozsef Nagy, Gyula Horvath, Imre Moravcsik
  • Patent number: 5106846
    Abstract: The present invention relates to compounds of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or nitro group;R.sub.2 means a C.sub.1-7 alkyl group optionally substituted by: a hydroxyl or oxo group; or an ester group containing 1 to 4 carbon atoms in the alkoxy moiety; or a C.sub.1-4 alkoxy, cyano, amino, C.sub.1-4 alkylamino, or dialkylamino group; or an acyl group containing 1 to 7 carbon atoms in the alkyl moiety; orR.sub.2 means an aryl-C.sub.1-7 alkyl group optionally bearing the substituents defined above for R.sub.2 in the alkyl chain and optionally substituted by halogen, nitro, C.sub.1-4 alkyl or alkoxy group in the benzene ring; orR.sub.2 represents an allyl, phenylallyl or phenylsulfonyl group, both latter groups optionally being substituted by halogen or a C.sub.1-4 alkyl group in the benzene ring; orR.sub.2 stands for a carbamoyl group substituted by one or two C.sub.1-4 alkyl group(s) or phenyl group on the nitrogen atom.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: April 21, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Istvan Szabadkai, Kalman Harsanyi, Agnes Lampert, Gyorgy Domany, Bela Hegedus, Elemer Ezer, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Krisztina Szekely