Abstract: Method for the production of formula (I) lumateperone or its acid addition salts so that the enantiomer compound with stereochemistry 6bR,10aS is separated form the cis racemate using resolution and the formula (II) stereoisomer is alkylated with 4-halo-4?-fluoro butyrophenone (X=I, Br, Cl) to produce the formula (I) lumateperone, or optionally its acid addition salt. The object of the invention also relates to the amorphous form of the morphologically uniform p-toluenesulfonic acid salt of lumateperone and to the naphthalene-2-sulfonic acid salt of lumateperone, to the 1:2 stoichiometry salt of lumateperone formed with naphthalene-2-sulfonic acid.

Abstract: Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.

Abstract: Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.

Abstract: Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.

Abstract: Various examples are provided for x-ray imaging of the microstructure of materials. In one example, a system for non-destructive material testing includes an x-ray source configured to generate a beam spot on a test item; a grid detector configured to receive x-rays diffracted from the test object; and a computing device configured to determine a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the test object. In another example, a method for determining a microstructure of a material includes illuminating a beam spot on the material with a beam of incident x-rays; detecting, with a grid detector, x-rays diffracted from the material; and determining, by a computing device, a microstructure image based at least in part upon a diffraction pattern of the x-rays diffracted from the material.

Abstract: A fuel container operating under overpressure and consisting of two shells is to be reinforced by means of an inner column so that, when the two shells are conjoined, a tension resistant connection is created. For this purpose, the column consists of a first and a second part connected to the respective shell, one part having catches, the other part having latching hooks, which catches and latching hooks for a tension resistant snap-in connection when joined together. For this purpose, both parts have latching surfaces and deflecting surfaces and the latching hook is resiliently displaceable.

Abstract: A fuel container operating under overpressure and consisting of two shells is to be reinforced by means of an inner column so that, when the two shells are conjoined, a tension resistant connection is created. For this purpose, the column consists of a first and a second part connected to the respective shell, one part having catches, the other part having latching hooks, which catches and latching hooks for a tension resistant snap-in connection when joined together. For this purpose, both parts have latching surfaces and deflecting surfaces and the latching hook is resiliently displaceable.

Abstract: An insulated vent cap includes a cover member having a circumferential rim extending around corresponding circumferential edges of both a substantially rigid cover sheet and a substantially rigid base sheet, wherein the base sheet is spaced apart from, and below, the cover sheet, to thereby define a sealed, air-tight insulating void there-between. A spacer extends from the coversheet to the base sheet, whereby the cover and base sheets are maintained spaced apart to maintain the insulated void or space between the cover and base sheets irregardless of ambient temperatures external and internal to the vent on an enclosure to which the vent cap is mounted.

Abstract: The invention relates to a system for detecting the defects of a wall used for enclosing a space where—generally liquid—materials are stored, with a coating on its internal side, especially a container wall, or/and the defects in the coating. In numerous fields of life all types of different materials, such as chemicals, solvents, petroleum oil and petroleum fractions, etc. need to be stored in a way excluding the possibility of these materials getting into the environment or other materials from the environment intermixing with the stored materials. In most cases such materials are stored in containers made of different materials, mostly metal, the walls of which holes may appear either as a result of corrosion or other damage, and through the appearing holes materials can flow either from outside into the container or from inside the container into the environment, and so the stored material may become unsuitable for use or serious environmental pollution may occur.

Abstract: A temperature compensation system comprises a laser driver having a first potentiometer, the laser driver configured to provide a first signal to a laser based on a value of the first potentiometer and an optical communication analyzer configured to provide a second signal indicative of a first output parameter of the laser. The temperature compensation system comprises a computer system configured to drive the first signal and receive the second signal and determine a first updated value for the first potentiometer to obtain a first desired laser output parameter value based on a first known value of the first potentiometer, the second signal, and the first desired laser output parameter value.

Abstract: A temperature compensation system comprises a laser driver having a first potentiometer, the laser driver configured to provide a first signal to a laser based on a value of the first potentiometer and an optical communication analyzer configured to provide a second signal indicative of a first output parameter of the laser. The temperature compensation system comprises a computer system configured to drive the first signal and receive the second signal and determine a first updated value for the first potentiometer to obtain a first desired laser output parameter value based on a first known value of the first potentiometer, the second signal, and the first desired laser output parameter value.

Abstract: The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane compounds of the formula (I), ##STR1## wherein Q.sup.1 and Q.sup.2 mean hydrogen or a group of the formula (III), ##STR2## in the groups of the formula (III) the R subtituents independently represent hydrogen, a C.sub.1-5 straight or branched chain alkyl group, a C.sub.2-5 straight or branched chain alkenyl group, phenyl or phenyl-C.sub.1-5 alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C.sub.1-5 alkyl, C.sub.1-5 alkoxy, cyano or nitro group(s), with the proviso that at least one of Q.sup.1 and Q.sup.

Abstract: Pharmaceutical composition for decorporating radioactive isotopes from living organisms comprising as active agent a product prepared by reacting 1,4,10,17-tetraoxa-7,16-diazacyclooctadecane with 2-bromomalonic acid disodium salt.

Abstract: The invention relates to an environment-protective agent consisting of silicon-containing minerals for adsorbing radiactive metal isotopes and toxic heavy metals, which comprises as silicon-containing minerals with a particle size of 0.001 to 0.5 mm; a natural diatomaceous earth and at least two natural zeolite minerals of the general formulaM.sub.x O.Al.sub.2 O.sub.3.YSiO.sub.2.7H.sub.2 OwhereinM stands for sodium, potassium or calcium;x is a number between 1 and 2 inclusive of both extreme values;Y is 3 or 10; andZ is 6 or 7treated by dilute acid, washed to neutral, dried to a constant weight at a temperature up to 115.degree.0 C. and then heat-treated at 150.degree. to 350.degree. C., preferably at 250.degree. C., where the amount of each mineral ingredient independently of each other is at least 0.1% by weight up to 99.8% by weight calculated to the total weight of the agent.

Abstract: The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;n is an integer of 1, 2 or 3;R.sup.1 represents hydrogen andR.sup.2 represents hydroxy-lower alkyl or lower alkoxy-lower alkyl or a group of the general formula IV, ##STR2## wherein Z stands for --O--, --S--, --NH-- or --N(lower alkyl)--; the dotted lines represent optional bonds; andm is 0 or 1; orR.sup.1 and R.sup.2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered heterocyclic group which may optionally contain a further oxygen, nitrogen or sulfur heteroatom and may be optionally substituted),and pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention exhibit radiosensitizing effect, make hypoxial cells highly sensitive towards radiation and may be used in radiation therapy.

Abstract: A method for removing the moisture adhered to surfaces of bodies and simultaneously for adjusting the surface temperature of the bodies to a predetermined value, in which air or steam having a temperature within the range of .+-.10 degrees centigrade of the surface temperature to be reached is streamed along the surface of the body, wherein an average velocity of stream of the air or steam is as follows: ##EQU1## wherein v.sub.1 is the average velocity of stream of the air or steam,g is the gravitational acceleration (g=9.81 m/s.sup.2),t.sub.v is the dynamic viscosity of the moisture in the state of its removal,G.sub.1 is the specific weight of the air or steam in the state or removal of the moisture,v.sub.v1 is the velocity of stream of the moisture at radius R.sub.1,R.sub.b is the hydraulic radius of the moistened surface,R.sub.1 is the hydraulic radius of the interface of the moisture and the air or steam,f.sub.1 is the degree of saturation of the air or steam,c is ##EQU2## wherein 0.

Abstract: A process and apparatus for the measurement of the dimensions of footwear lasts and for determining reference directions for measurement and manufacture are described. Horizontal and vertical projection tracings are made from a master last, by a mechanical sensing-following mechanism combined with an optical projection system. Deviations from desired positions are rectified by displacing the last, in at least two directions. The location and magnitude of deviations can be marked on the last.

Abstract: The invention relates to novel peptides of formula (I),A-Try-B-Asp-Phg-NH.sub. 2 (I)whereinA is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl or E-aminooxy-acyl, wherein E is benzoyl or straight-chained or branched C.sub.1-5 aliphatic acyl, andB represents methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl,or acid addition salts or complexes thereof. The novel compounds according to the invention exert gastrin effects and can be applied to advantage in the diagnostics and therapy. The novel compounds of formula (I) are prepared according to the invention by reacting a tetrapeptideamide of formula (II),H-Try-B-Asp-Phg-NH.sub. 2 (II)wherein B is as defined above, with an (aminooxy)-acyl containing compound of the general formula A.sub.1 -X, whereinA.sub.1 has the same meanings as A with the exception of the (aminooxy)-acyl, andX is hydroxy group, halogen, pivaloyloxy, a group of the formula R--O--CO.sub.

Abstract: Peptides of the formula:A--Trp--B--Asp--Phe--NH--Ywherein A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl, or E-aminooxy-acyl, wherein E is benzoyl or straight-chain or branched C.sub.1-5 aliphatic acyl, B is methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, and Y is hydrogen or carboxymethoxy, and pharmaceutically acceptable acid-addition salts or complexes thereof have gastric-acid secretion increasing effects.

Abstract: A process for the preparation of L-aspartyl-(O-sulfato-L-tyrosyl)-L-methionyl-glycyl-L-tryptophyl-L-methion yl-L-aspartyl-L-phenylalanine amide, which comprises treating the protected octapeptide amide of the general formula (II) ##STR1## wherein X is BOC, Cbz or Ddz,Y is O.sup.t Bu, OBzl or OH andW is O.sup.t Bu, OBzl or OH,in the presence of an ether with an excess of the complex compound of sulfur trioxide and a tertiary amine containing at least one alkyl group, converting the obtained sulfate ester of the protected octapeptide amide into an alkali metal salt and simultaneously removing the formyl group from the tryptophan unit by reacting the sulfate ester with an alkali metal hydroxide, and then splitting off the remaining protective groups by acidolysis.