Patents by Inventor Laszlo Z. Bito

Laszlo Z. Bito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thioprostaglandins and -prostaglandin-like compounds and therapeutic uses thereof
    Patent number: 5516796
    Abstract: Thiosubstituted prostaglandin derivatives and related compounds having the general structure ##STR1## useful as intraocular pressure reducing agents; pharmaceutical compositions containing such compounds; and methods of treatment using such compositions are disclosed.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: May 14, 1996
    Assignee: Kabi Pharmacia AB
    Inventors: Johan W. Stjernschantz, Bahram Resul, Laszlo Z. Bito
  • Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
    Patent number: 4952581
    Abstract: This invention provides a method for treating ocular hypertension or glaucoma in a subject's eye. The method comprises contacting the surface of the eye with an effective intraocular pressure reducing amount of a mixture of an adrenergic blocking agent and a prostaglandin or prostaglandin derivative in an ophthalmically compatible carrier, so as to reduce the intraocular pressure of the eye and maintain such reduced intraocular pressure.This invention also provides a composition for topical treatment of ocular hypertension or glaucoma in the eye of a subject. The composition comprises an effective intraocular pressure reducing amount of a mixture of an adrenergic block agent and a prostaglandin or prostaglandin derivative in an ophthalmically compatible carrier.
    Type: Grant
    Filed: December 30, 1988
    Date of Patent: August 28, 1990
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Laszlo Z. Bito, Johan W. Stjernschantz
  • Use of A, B and C prostaglandins and derivatives thereof to treat ocular hypertension and glaucoma
    Patent number: 4883819
    Abstract: This invention provides a method for treating hypertension or glaucoma in a subject's eye which comprises contacting the surface of the eye with an effective intraocular pressure reducing amount of one or more prostaglandins selected from the group consisting of prostaglandin A (PGA), prostaglandin B (PGB), prostaglandin C (PGC), derivatives of PGA, PGB, and PGC, conjugates of PGA and conjugated derivatives of PGA, so as to reduce the intraocular pressure of the eye and maintain such reduced intraocular pressure. Also provided is a composition for topical treatment of hypertension or glaucoma in the eye of a subject which comprises an effective intraocular pressure reducing amount of one or more prostaglandins selected from the group consisting of PGA, PGB and PGC, derivatives of PGA, PGB and PGC and conjugates of PGA and an opthalmically compatible carrier.
    Type: Grant
    Filed: March 5, 1987
    Date of Patent: November 28, 1989
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Laszlo Z. Bito
  • Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
    Patent number: 4599353
    Abstract: Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an afflicted eye. Eicosanoids, particularly the prostaglandins PGE.sub.2 and PGF.sub.2.alpha., and derivatives thereof, have been found effective in quantities less than about 1000 .mu.g per eye. Ophthalmic compositions containing C.sub.1 to C.sub.5 alkyl esters of PGF.sub.2.alpha. are presently preferred for use in treating ocular hypertension and glaucoma in primates, including man.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: July 8, 1986
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Laszlo Z. Bito