Patents by Inventor Latha Nair

Latha Nair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2?-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
    Patent number: 9156872
    Abstract: The present invention relates to 2?-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2?-Azido Substituted Nucleoside Derivative, and methods of using the 2?-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: October 13, 2015
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Vinay Girijavallabhan, F. George Njoroge, Stephane Bogen, Frank Bennett, Vishal Verma, Ashok Arasappan, Kevin Chen, Ying Huang, Angela Kerekes, Latha Nair, Dmitri Pissarnitski, Qun Dang, Ian Davies, David B. Olsen, Andrew Stamford, Joseph P. Vacca
  • 2?-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases
    Patent number: 9150603
    Abstract: The present invention relates to 2?-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2?-Cyano Substituted Nucleoside Derivative, and methods of using the 2?-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: October 6, 2015
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Vinay Girijavallabhan, F. George Njoroge, Stephane Bogen, Angela Kerekes, Frank Bennett, Ying Huang, Latha Nair, Dmitri Pissarnitski, Vishal Verma, Qun Dang, Ian Davies, David B. Olsen, Andrew Stamford, Joseph P. Vacca
  • 2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
    Publication number: 20140206640
    Abstract: The present invention relates to 2?-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2?-Azido Substituted Nucleoside Derivative, and methods of using the 2?-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
    Type: Application
    Filed: April 11, 2012
    Publication date: July 24, 2014
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Vinay Girijavallabhan, F. George Njoroge, Stephane Bogen, Frank Bennett, Vishal Verma, Ashok Arasappan, Kevin X. Chen, Ying Huang, Angela Kerekes, Latha Nair, Dimitri Pissarnitski, Qun Dang, Ian Davies, David B. Olsen, Andrew Stamford, Joseph P. Vacca
  • 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF USEFUL FOR THE TREATMENT OF VIRAL DISEASES
    Publication number: 20140161770
    Abstract: The present invention relates to 2?-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2?-Cyano Substituted Nucleoside Derivative, and methods of using the 2?-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
    Type: Application
    Filed: April 11, 2012
    Publication date: June 12, 2014
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Vinay Girijavallabhan, F. George Njoroge, Stephane Bogen, Angela Kerekes, Frank Bennett, Ying Huang, Latha Nair, Dmitri Pissarnitski, Vishal Verma, Qun Dang, Ian Davies, David B. Olsen, Andrew Stamford, Joseph P. Vacca
  • Substituted Piperidines that Increase P53 Activity and the Uses Thereof
    Publication number: 20080004287
    Abstract: In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 3, 2008
    Inventors: Yao Ma, Brian Lahue, Gerald Shipps, Yaolin Wang, Stephane Bogen, Matthew Voss, Latha Nair, Yuan Tian, Ronald Doll, Zhuyan Guo, Corey Strickland, Rumin Zhang, Mark McCoy, Weidong Pan, Elise Siegel, Craig Gibeau
  • Novel inhibitors of Hepatitis C virus NS3 protease
    Publication number: 20070142301
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: December 21, 2006
    Publication date: June 21, 2007
    Inventors: Stephane Bogen, Weidong Pan, Sumei Ruan, Kevin Chen, Ashok Arasappan, Srikanth Venkatraman, Latha Nair, Mousumi Sannigrahi, Frank Bennett, Anil Saksena, F. Njoroge, Viyyoor Girijavallabhan
  • Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus
    Publication number: 20070093430
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: November 20, 2006
    Publication date: April 26, 2007
    Inventors: Kevin Chen, F. Njoroge, Mousumi Sannigrahi, Latha Nair, Weiying Yang, Bancha Vibulbhan, Srikanth Venkatraman, Ashok Arasappan, Stephane Bogen, Frank Bennett, Viyyoor Girijavallabhan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20070049536
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: October 3, 2006
    Publication date: March 1, 2007
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20070032434
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: October 3, 2006
    Publication date: February 8, 2007
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
    Publication number: 20070032433
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: January 18, 2002
    Publication date: February 8, 2007
    Inventors: Anil Saksena, Viyyoor Girijavallabhan, Raymond Lovey, Edwin Jao, Frank Bennett, Jinping Mc Cormick, Haiyan Wang, Russell Pike, Stephane Bogen, Tin-Yau Chan, Yi-Tsung Liu, Zhaoning Zhu, F. Njoroge, Ashok Arasappan, Tejal Parekh, Ashit Ganguly, Kevin Chen, Srikanth Venkatraman, Henry Vaccaro, Patrick Pinto, Bama Santhanam, Scott Kemp, Odile Levy, Marguerita Lim-wilby, Susan Tamura, Wanli Wu, Siska Hendrata, Yuhua Huang, Jesse Wong, Latha Nair
  • Novel compounds as inhibitors of hepatitis C virus NS3 serine protease
    Publication number: 20050288233
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 29, 2005
    Inventors: Srikanth Venkatraman, F. Njoroge, Melissa Blackman, Wanli Wu, Latha Nair, Ashok Arasappan, Stephane Bogen, Kevin Chen, Mousumi Sannigrahi, Frank Bennett, Viyyoor Girijavallabhan
  • Novel inhibitors of hepatitis C virus NS3 protease
    Publication number: 20050267043
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: December 1, 2005
    Inventors: Stephane Bogen, Weidong Pan, Sumei Ruan, Kevin Chen, Ashok Arasappan, Srikanth Venkatraman, Latha Nair, Mousumi Sannigrahi, Frank Bennett, Anil Saksena, F. Njoroge, Viyyoor Girijavallabhan
  • Novel ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus
    Publication number: 20050222047
    Abstract: The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
    Type: Application
    Filed: February 24, 2005
    Publication date: October 6, 2005
    Inventors: Kevin Chen, F. Njoroge, Mousumi Sannigrahi, Latha Nair, Weiying Yang, Bancha Vibulbhan, Srikanth Venkatraman, Ashok Arasappan, Stephane Bogen, Frank Bennett, Viyyoor Girijavallabhan