Abstract: The present disclosure provides methods for producing Phyla dulcis plants and plant parts that are substantially camphor-free and also have an increased level of hernandulcin. Phyla dulcis plants and plant parts, as well as compositions comprising the same, are also provided herein. The present disclosure provides methods that utilize the regulation of the terpenoid biochemical pathways of P. dulcis as opposed to previous methods that depend on chemical synthesis or genetic, enzyme, microbial, and plant tissue engineering.

Abstract: Systems and methods are provided for semi-automated, portable, ultrasound guided cannulation. The systems and methods provide for image analysis to provide for identification of anatomical landmarks from image data. The image analysis provides for guidance for insertion of a cannulation system into an airway of a subject which may be accomplished by a non-expert based upon the guidance provided. The system further enables a single person to perform the cannulation rather than the typical 2 or more people. The guidance may include an indicator or a mechanical guide to guide a user for inserting the cannulation system into a subject to penetrate the airway of interest.

Abstract: An industrial communication module includes a controller and a common interface coupled to the controller. The common interface is configured to couple to a plurality of different types of sensor modules. The industrial communication module includes protocol/output circuitry coupled to the controller and configured to provide an output to a remote device. A sensor module includes a controller and a common interface coupled to the controller. The common interface is configured to couple to a plurality of different types of industrial communication modules. The sensor module includes measurement processing circuitry coupled to the controller and configured to measure an analog electrical characteristic of a sensor and provide a digital indication of the measured analog electrical characteristic to the controller.

Abstract: Fastener storage is presented. The fastener storage comprises a disc with a plurality of apertures through a first face of the disc and arranged in a plurality of rings concentric with the disc, and a plurality of machine-readable identifiers on the first face of the disc.

Abstract: An end effector for confined space manufacturing operations and methods of use are presented. The end effector comprises a pair of kinematic machines connected in series, and an operational head connected to a first platform of a first kinematic machine of the pair of kinematic machines, the operational head configured to perform number of manufacturing operations on a structure.

Abstract: A fastening end effector is presented. The fastening end effector comprises a hammering insertion die translatable into and out of a housing of the fastening end effector along a longitudinal axis of the fastening end effector; and grippers positioned circumferentially around the hammering insertion die to hold a head of a fastener against the hammering insertion die, the grippers independently moveable relative to the hammering insertion die.

Abstract: An end effector is presented. The end effector comprises a torque wrench and a first vacuum source. The torque wrench is configured to hold a collar and apply a single-sided clamp-up to a structure. The first vacuum source is pneumatically connected to the torque wrench and configured to supply a vacuum for the single-sided clamp-up.

Abstract: An end effector is presented. The end effector comprises a housing, an actuated mechanical retainer, and a normalizing nosepiece assembly. The actuated mechanical retainer is connected to the housing and configured to selectively constrain and release the normalizing nosepiece assembly from the housing. The normalizing nosepiece assembly is moveable relative to the housing and having a nosepiece bushing configured to contact a workpiece.

Abstract: A scope system is provided including an elongate tube with a distal portion and a lumen extending therethrough. The scope system also includes at least one accessory channel extending from a proximal end to a distal end and having with an accessory lumen extending therethrough, the at least one accessory channel movably disposed at least partially within the lumen of the elongate tube. The at least one accessory channel includes a distal section and a forward-viewing configuration and a side-viewing configuration. In the forward-viewing configuration, the distal section of the at least one accessory channel is substantially parallel to the distal portion of the elongate tube and in the side-viewing configuration, the distal section of the at least one accessory channel is arced at a radius greater than a radius of the distal portion of the elongate tube.

Abstract: The present invention provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, methods of measuring IDO activity as a way to identify a subpopulation of subjects with prostate cancer that may benefits from the treatment methods described herein are provided.

Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising chimeric antigen receptors (CARs) capable of binding human IL13R?2. Also provided are bispecific CARs, parallel CARs, tandem CARs, BiTEs, BiTE/CARs, and BiTE/BiTEs. Compositions and methods of treatment are also provided.

Abstract: A watercraft deck cover system. The system provides a cover member. The cover member has fasteners placed along the perimeter of the cover member. A connector is on the top of the cover member and is designed to have a cord attached to the connector. The cord is secured to a frame at an overhead arm extending from the frame. When the fasteners are secured to a watercraft and connector is elevated by the cord, water is prevented from pooling on the deck of the watercraft.

Abstract: A scope system is provided including an elongate tube with a distal portion and a lumen extending therethrough. The scope system also includes at least one accessory channel extending from a proximal end to a distal end and having with an accessory lumen extending therethrough, the at least one accessory channel movably disposed at least partially within the lumen of the elongate tube. The at least one accessory channel includes a distal section and a forward-viewing configuration and a side-viewing configuration. In the forward-viewing configuration, the distal section of the at least one accessory channel is substantially parallel to the distal portion of the elongate tube and in the side-viewing configuration, the distal section of the at least one accessory channel is arced at a radius greater than a radius of the distal portion of the elongate tube.

Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.

Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.

Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.

Abstract: A system allows for rapid intraosseous delivery of fluids from a fluid reservoir via an intraosseous port having a tip disposed within the bone marrow of a patient. The system includes a housing with a chamber and a plunger. An actuator is moveable between first and second positions to move the plunger between the distal and proximal positions. A valve housing includes a first one-way valve fluidly coupled to the fluid reservoir, and a second one-way valve fluidly coupled to the intraosseous port. The valves of the valve housing are oriented such that movement of the actuator from the first to the second position moves the plunger from the distal to the proximal position, drawing fluid from the fluid reservoir through the first valve and into the chamber. Movement of the actuator from the second to the first position moves the plunger from the proximal to the distal position, driving fluid from the chamber through the port and second valve and through the intraosseous port.

Abstract: Methods of treating patients with inflammatory bowel disease, intestinal fibrosis, or Crohn's disease involve administering a therapeutic amount of CARD-024 or related compound.

Abstract: An apparatus and method is described for determining the location of a object inside a patient. Three dimensional image data of the patient is obtained by an imaging modality such as a C-arm X-ray device. The same or another imaging modality may be used to obtain projection radiographic images, having a coordinate system that can be registered with respect to that of the three dimensional image. The location of one or more features of a medical treatment device such as a needle or a catheter introduced into the imaging filed of view is determined either by an operator or by image analysis, in at least two projection radiographic images, and the position of the feature located in the three-dimensional volume. The projection on a radiographic image of a vector joining a first and a second position is used to assist in guiding the medical treatment device inside of the patient.

Abstract: A system and method for receiving services is presented. The system comprises a first splitter having an input, a first output and a slaved output receiving a first signal at the input having a single polarization including a first service and a slaved service, wherein the first signal is directed to the first output and the slaved output and selected by a first control signal applied at the input, a first tuner receiving the first output and tuning the first service and a slaved tuner receiving the slaved output and tuning the slaved service. The method comprises generating a first control signal to select a first signal, receiving a first signal including a first service and a slaved service, wherein the first service and the slaved service are at the same polarization, splitting the first signal with a first splitter to a first output and a first slaved output, tuning the first service from the first output with a first tuner and tuning the slaved service from the slaved output with a slaved tuner.