Patents by Inventor Laura A. Niklason

Laura A. Niklason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7993567
    Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: August 9, 2011
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Lisa A. Scott-Carnell, Ralph M Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi
  • Publication number: 20090108503
    Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.
    Type: Application
    Filed: June 2, 2008
    Publication date: April 30, 2009
    Applicant: USA as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Lisa A. Scott-Carnell, Ralph M. Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi
  • Publication number: 20090028817
    Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 29, 2009
    Inventors: Laura Niklason, Yuling Li, Juliana Blum, Shannon Dahl, Geoffrey Erickson, Frank Zeigler
  • Publication number: 20080248080
    Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.
    Type: Application
    Filed: May 21, 2008
    Publication date: October 9, 2008
    Applicant: Duke University
    Inventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
  • Publication number: 20060073590
    Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.
    Type: Application
    Filed: October 19, 2005
    Publication date: April 6, 2006
    Applicant: Duke University
    Inventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
  • Patent number: 6962814
    Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: November 8, 2005
    Assignee: Duke University
    Inventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
  • Publication number: 20020115208
    Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.
    Type: Application
    Filed: August 16, 2001
    Publication date: August 22, 2002
    Inventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason