Patents by Inventor Laura Bedzyk

Laura Bedzyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACID-CLEAVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS
    Publication number: 20140221608
    Abstract: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 7, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: LAURA A BEDZYK, Stephen R. Fahnestock, Tanja Maria Gruber, Daniel P. O'Keefe, Pierre E Rouviere
  • Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
    Patent number: 8748399
    Abstract: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: June 10, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Laura A Bedzyk, Stephen R Fahnestock, Tanja Maria Gruber, Daniel P O'Keefe, Pierre E Rouviere
  • ACID-CLEAVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS
    Publication number: 20140080998
    Abstract: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
    Type: Application
    Filed: November 12, 2013
    Publication date: March 20, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: LAURA A BEDZYK, Stephen R. Fahnestock, Tanja Maria Gruber, Daniel P. O'Keefe, Pierre E Rouviere
  • Acid-cleavable linkers exhibiting altered rates of acid hydrolysis
    Patent number: 8609621
    Abstract: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: December 17, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Laura A. Bedzyk, Stephen R. Fahnestock, Tanja Maria Gruber, Daniel P. Okeefe, Pierre E. Rouviere
  • ACID-CLEVABLE LINKERS EXHIBITING ALTERED RATES OF ACID HYDROLYSIS
    Publication number: 20120122153
    Abstract: An acid-cleavable peptide linker comprising aspartic acid and proline residues is disclosed. The acid-cleavable peptide linker provides an altered sensitivity to acid-hydrolytic release of peptides of interest from fusion peptides of the formula PEP1-L-PEP2. The inventive linker, L, is described in various embodiments, each of which provides substantially more rapid acid-release of peptides of interest than does a single aspartic acid-proline pair. In an additional aspect, a method of increasing the stability of an acid cleavable linkage to acid hydrolysis is also provided.
    Type: Application
    Filed: September 7, 2011
    Publication date: May 17, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: LAURA A. BEDZYK, Stephen R. Fahnestock, Tanja Maria Gruber, Daniel P. Okeefe, Pierre E. Rouviere
  • METHOD FOR THE DETECTION OF DIAGNOSTIC RNA
    Publication number: 20110020794
    Abstract: Methods for the direct detection of diagnostic target RNA have been developed, which obviate the need for time consuming RNA purification and isolation procedures.
    Type: Application
    Filed: July 13, 2009
    Publication date: January 27, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: LAURA A. BEDZYK, Daniel R. Demarco, Richard C. Ebersole, Raymond E. Jackson, Stephen Varkey, Rick Ye
  • Method for the direct detection of diagnostic RNA
    Patent number: 7575864
    Abstract: Methods for the direct detection of diagnostic target RNA have been developed, which obviate the need for time consuming RNA purification and isolation procedures.
    Type: Grant
    Filed: May 24, 2005
    Date of Patent: August 18, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventors: Laura Bedzyk, Daniel DeMarco, Richard Ebersole, Raymond Jackson, Stephen Varkey, Rick Ye
  • Method for the direct detection of diagnostic RNA
    Publication number: 20050266468
    Abstract: Methods for the direct detection of diagnostic target RNA have been developed, which obviate the need for time consuming RNA purification and isolation procedures.
    Type: Application
    Filed: May 24, 2005
    Publication date: December 1, 2005
    Inventors: Laura Bedzyk, Daniel DeMarco, Richard Ebersole, Raymond Jackson, Stephen Varkey, Rick Ye
  • Natural promoters for gene expression and metabolic monitoring in bacillus species
    Publication number: 20040072354
    Abstract: Genes have been identified in the Bacillus genome that are responsive to various metabolic conditions and growth cycle changes. The new responsiveness of these genes allows for their use in regulated gene expression in Bacillus sp. and for the monitoring of bioreactor health.
    Type: Application
    Filed: November 1, 2002
    Publication date: April 15, 2004
    Inventors: Laura A. Bedzyk, Tao Wang, Rick W. Ye
  • Natural promoters for gene expression and metabolic monitoring in bacillus species
    Publication number: 20040009556
    Abstract: Genes have been identified in the Bacillus genome that are responsive to various metabolic conditions and growth cycle changes. The new responsiveness of these genes allows for their use in regulated gene expression in Bacillus sp. and for the monitoring of bioreactor health.
    Type: Application
    Filed: June 24, 2003
    Publication date: January 15, 2004
    Inventors: Laura A. Bedzyk, Tao Wang, Rick W. Ye
  • Natural promoters for gene expression and metabolic monitoring in bacillus species
    Patent number: 6617148
    Abstract: Genes have been identified in the Bacillus genome that are responsive to various metabolic conditions and growth cycle changes. The new responsiveness of these genes allows for their use in regulated gene expression in Bacillus sp. and for the monitoring of bioreactor health.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: September 9, 2003
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Laura A. Bedzyk, Tao Wang, Rick Ye
  • Natural promoters for gene expression and metabolic monitoring in bacillus species
    Publication number: 20020155612
    Abstract: Genes have been identified in the Bacillus genome that are responsive to various metabolic conditions and growth cycle changes. The new responsiveness of these genes allows for their use in regulated gene expression in Bacillus sp. and for the monitoring of bioreactor health.
    Type: Application
    Filed: June 26, 2001
    Publication date: October 24, 2002
    Inventors: Laura A. Bedzyk, Tao Wang, Rick Ye