Patents by Inventor Laura Brown

Laura Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240138534
    Abstract: An interchangeable ring system is provided. The interchangeable ring system includes a shank and a head. The shank includes a receiving hole, and the head includes a peg. The peg is removably inserted into the receiving hole such that the head is secured on the shank. The shank includes a clamp at least partially extending into the receiving hole.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 2, 2024
    Applicant: STERLING JEWELERS, INC.
    Inventors: Laura BROWN, Sarah BLUM, Jill SUDDENDORF
  • Patent number: 11179422
    Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: November 23, 2021
    Assignee: Depuy Synthes Products, Inc.
    Inventors: Laura Brown, Sridevi Dhanaraj, Agnieszka Seyda
  • Patent number: 10227290
    Abstract: Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: March 12, 2019
    Assignees: The Regents of the University of California, President and Fellows of Harvard College
    Inventors: Michael A. Fischbach, Jeffrey A. Bluestone, Cristina Penaranda, Laura Brown, Jon Clardy
  • Patent number: 9504719
    Abstract: Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: November 29, 2016
    Assignee: DePuy Synthes Products, Inc.
    Inventors: Laura Brown, Alexander M. Harmon, Anna Gosiewska
  • Patent number: 9307940
    Abstract: A testing apparatus for testing a user's sustained attention comprises at least one stimulus-provider and a controller for controlling the stimulus-provider to provide at least one target stimulus, wherein the controller is configured to perform at least one operating procedure and the or each operating procedure comprises controlling the stimulus-provider to provide a sequence of target stimuli to the user.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: April 12, 2016
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
    Inventors: Alasdair MacLullich, Laura Brown, Jonathan Adler
  • Publication number: 20140377291
    Abstract: Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
    Type: Application
    Filed: February 7, 2013
    Publication date: December 25, 2014
    Inventors: Michael A. Fischbach, Jeffrey A. Bluestone, Cristina Penaranda, Laura Brown, Jon Clardy
  • Publication number: 20120271194
    Abstract: A testing apparatus for testing a user's sustained attention comprises at least one stimulus-provider and a controller for controlling the stimulus-provider to provide at least one target stimulus, wherein the controller is configured to perform at least one operating procedure and the or each operating procedure comprises controlling the stimulus-provider to provide a sequence of target stimuli to the user.
    Type: Application
    Filed: October 7, 2010
    Publication date: October 25, 2012
    Applicant: The University Court of the University of Edinburgh
    Inventors: Alasdair MacLullich, Laura Brown, Jonathan Adler
  • Publication number: 20090087855
    Abstract: Novel sequence tagged sites (STSs), probes and primers useful, e.g., for detecting the presence or absence of an STS in a sample, and methods of using these STSs, probes and primers, e.g., in methods of detecting alterations in the Y chromosome are disclosed. These compositions are also useful in methods of diagnosing or aiding in the diagnosis and/or cause of reduced sperm count and in methods of predicting or aiding in the prediction of the likelihood of success of infertility treatments.
    Type: Application
    Filed: October 14, 2008
    Publication date: April 2, 2009
    Inventors: David C. Page, Steven G. Rozen, Helen Skaletsky, Sjoerd Repping, Tomoko Kuroda-Kawaguchi, Julian Lange, Laura Brown
  • Publication number: 20070190878
    Abstract: Cleaning sheets comprise an additive that is selected to enhance the pick up and retention of particulate material from surfaces, while minimizing the amount of residue left on the surface being cleaned. If the type of additive and level of additive on the cleaning sheet are not carefully selected, the sheet will leave a residue on the surface being cleaned resulting in filming and streaking of the surface that is unacceptable to consumers. The additive is preferably selected from the group consisting of a wax, an oil, and mixtures thereof. Cleaning implements comprise a mop head having a resilient bottom surface, a portion of which preferably has a substantially smooth curved profile or crown which engages a removable cleaning sheet.
    Type: Application
    Filed: March 19, 2007
    Publication date: August 16, 2007
    Inventors: Kenneth Willman, Michael Maile, Mark Kacher, Marty Vanderstelt, Laura Brown, Benjamin Clare, Nicola Policicchio, Nirav Shah
  • Publication number: 20070141160
    Abstract: A method of treatment of osteoarthritis is described, where a therapeutically effective amount of a composition having biodegradable microparticles in an aqueous vehicle is delivered into the intra-articular space of a joint. In one aspect, the microparticle-containing composition is injected into the synovial fluid-containing portion of an affected joint.
    Type: Application
    Filed: December 15, 2005
    Publication date: June 21, 2007
    Inventors: Laura Brown, Han Cui, Zhangwen Wu
  • Publication number: 20070107156
    Abstract: Cleaning sheets comprise an additive that is selected to enhance the pick up and retention of particulate material from surfaces, while minimizing the amount of residue left on the surface being cleaned. If the type of additive and level of additive on the cleaning sheet are not carefully selected, the sheet will leave a residue on the surface being cleaned resulting in filming and streaking of the surface that is unacceptable to consumers. The additive is preferably selected from the group consisting of a wax, an oil, and mixtures thereof. Cleaning implements comprise a mop head having a resilient bottom surface, a portion of which preferably has a substantially smooth curved profile or crown which engages a removable cleaning sheet.
    Type: Application
    Filed: January 11, 2007
    Publication date: May 17, 2007
    Inventors: Kenneth Willman, Michael Maile, Mark Kacher, Marty Vanderstelt, Laura Brown, Benjamin Clare, Nicola Policicchio
  • Publication number: 20060272115
    Abstract: Disposable cleaning sheets for removing debris from a surface comprise a substrate and a plurality of protrusions affixed to the substrate, wherein the cleaning sheet is removably attachable to a cleaning implement. The protrusions are preferably hook-shaped. The preferred hook-shaped protrusions can be made of certain thermoplastic resins and can have certain geometric configurations. The protrusions can be affixed to the substrate via a variety of process and are preferably affixed to the substrate in one or more zones of the substrate. Methods of removing debris from a surface comprise contacting the surface with a cleaning sheet of the present invention.
    Type: Application
    Filed: August 11, 2006
    Publication date: December 7, 2006
    Inventors: Mark Kacher, Michael Maile, Andrea Switzer, Arthur Wong, Laura Brown, Preston Rhamy
  • Publication number: 20060166228
    Abstract: Novel sequence tagged sites (STSs), probes and primers useful, e.g., for detecting the presence or absence of an STS in a sample, and methods of using these STSs, probes and primers, e.g., in methods of detecting alterations in the Y chromosome are disclosed. These compositions are also useful in methods of diagnosing or aiding in the diagnosis and/or cause of reduced sperm count and in methods of predicting or aiding in the prediction of the likelihood of success of infertility treatments.
    Type: Application
    Filed: August 1, 2005
    Publication date: July 27, 2006
    Inventors: David Page, Steven Rozen, Helen Skaletsky, Sjoerd Repping, Tomoko Kuroda-Kawaguchi, Julian Lange, Laura Brown
  • Publication number: 20060154366
    Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products such as lysates related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions such as osteoarthritis.
    Type: Application
    Filed: December 22, 2005
    Publication date: July 13, 2006
    Inventors: Laura Brown, Sridevi Dhanaraj, Agnieszka Seyda
  • Publication number: 20060153816
    Abstract: Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.
    Type: Application
    Filed: December 22, 2005
    Publication date: July 13, 2006
    Inventors: Laura Brown, Alexander Harmon, Anna Gosiewska
  • Publication number: 20060122150
    Abstract: A pharmaceutical composition for use in treating a joint-capsule arthropathy comprising an effective amount of one or more of a locally administered, optionally encapsulated therapeutic agent in admixture with a hyaluronic acid delivery vehicle and a method for use thereof in treating a joint-capsule arthropathy by intra-articular injection.
    Type: Application
    Filed: September 30, 2005
    Publication date: June 8, 2006
    Inventors: Dennis Argentieri, Demetrius Carter, Laura Brown, Jeffrey Geesin, John Siekierka, Han Cui
  • Publication number: 20050221612
    Abstract: The present invention is directed to a low thermal budget MOL liner to be used in the fabrication of a semiconductor device. The low thermal budget MOL liner of the present invention, which is formed by treating a titanium-deposited layer with an in-situ plasma nitridization step, results in a significantly improved high performance device as the need for the higher thermal annealing process presently used in the making of such devices can be avoided. The present invention is further directed to a method of making the resulting semiconductor device, as well as the semi-conductor device itself.
    Type: Application
    Filed: April 5, 2004
    Publication date: October 6, 2005
    Applicants: INTERNATIONAL BUSINESS MACHINES CORPORATION, ADVANCED MICRO DEVICES, INC.
    Inventors: Laura Brown, Fen Jamin, Kin-Sang Lam, Ying Li, Yun Wang, Horatio Wildman, Kwong Wong
  • Publication number: 20050038001
    Abstract: The present invention relates to injecting a cycline compound into a diseased intervertebral disc.
    Type: Application
    Filed: August 13, 2003
    Publication date: February 17, 2005
    Applicant: DePuy Spine, Inc.
    Inventors: Mohamed Attawia, Thomas DiMauro, Hassan Serhan, Melissa Grace, Sudhakar Kadiyala, David Urbahns, Scott Bruder, Gregory Collins, Laura Brown, Jeff Geesin, Pamela Plouhar, Catherine Smith, John Siekierka
  • Publication number: 20050025765
    Abstract: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-? synthesis; iii) an inhibitor of membrane-bound TNF-?; iv) an inhibitor of a natural receptor of TNF-?; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.
    Type: Application
    Filed: July 30, 2003
    Publication date: February 3, 2005
    Applicant: DePuy Spine, Inc.
    Inventors: Thomas DiMauro, Mohamed Attawia, Hassan Serhan, Martin Reynolds, Melissa Grace, Sudhakar Kadiyala, David Urbahns, Scott Bruder, Gregory Collins, Laura Brown, Jeff Geesin, Pamela Plouhar, Catherine Smith, John Siekierka
  • Patent number: D318955
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: August 13, 1991
    Inventor: Laura Brown