Patents by Inventor Laura Buffa

Laura Buffa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS
    Publication number: 20240285621
    Abstract: The present invention relates to pyrazolyl-pyrimidine derivatives, to a process for their preparation, to pharmaceutical compositions comprising them, and to their use as therapeutic agents. The compounds are kinase inhibitors, in particular are inhibitors of Spleen Tyrosine Kinase (SYK) and can be used in treatment of cancer, cell proliferative disorders, viral infections, immune disorders, neurodegenerative disorders and cardiovascular diseases.
    Type: Application
    Filed: September 15, 2021
    Publication date: August 29, 2024
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Simona BINDI, Laura BUFFA, Giovanni CERVI, Roberto D'ALESSIO, Maria MENICHINCHERI, Michele MODUGNO
  • SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20240217969
    Abstract: The application relates to substituted pyrrole carboxamide derivatives of formula (I) which modulate the activity of cycle 7-related protein kinase (Cdc7). The compounds of this invention are therefore useful in treating diseases related to dysregulated kinases activity, for example cancer, cell proliferative disorders, viral infections, immune disorders, neurodegenerative disorders, cardiovascular diseases and bone related diseases. The application also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and their medical uses.
    Type: Application
    Filed: March 22, 2022
    Publication date: July 4, 2024
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Helena POSTERI, Laura BUFFA, Danilo MIRIZZI, Ilaria MOTTO, Maria MENICHINCHERI
  • 6-amino-7-bicyclo-7-deaza-purine derivatives as protein kinase inhibitors
    Patent number: 10221181
    Abstract: 6-Amino-7-bicyclo-7-deaza-purine derivatives of formula (I): modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 5, 2019
    Assignee: NERVIANO MEDICAL SCIENCES S.r.l.
    Inventors: Laura Buffa, Maria Menichincheri, Ilaria Motto, Francesca Quartieri
  • 6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
    Publication number: 20170327506
    Abstract: The present invention relates to 6-amino-7-bicyclo-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: November 12, 2015
    Publication date: November 16, 2017
    Applicant: NERVIANO MEICAL SCIENCES S.r.l.
    Inventors: Laura BUFFA, Maria MENICHINCHERI, Ilaria MOTTO, Francesca QUARTIERI
  • Pyrrolo[2,3-D]pyrimidine derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 9682083
    Abstract: The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: June 20, 2017
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Mauro Angiolini, Laura Buffa, Maria Menichincheri, Ilaria Motto, Paolo Polucci, Gabriella Traquandi, Fabio Zuccotto
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20160166575
    Abstract: The present invention relates to 6-amino-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
    Type: Application
    Filed: May 7, 2014
    Publication date: June 16, 2016
    Inventors: Mauro Angiolini, Laura Buffa, Maria Menichincheri, Ilaria Motto, Paolo Polucci, Gabriella Traquandi, Fabio Zuccotto