Patents by Inventor Laura C. Pendleton

Laura C. Pendleton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides targeted against the extended 5?-UTR region of argininosuccinate synthase and uses thereof
    Patent number: 7718625
    Abstract: The present invention is based in part on the discovery that the upstream open reading frame (uORF) in the extended 5?-untranslated region (5?-UTR) argininosuccinate synthase (AS) mRNA species is functional, and when functional, limits overall AS expression as well as nitric oxide (NO) production. Thus, the extended 5?-UTR AS mRNA species is a mechanism for regulating AS expression and NO production, and provides a target for the treatment of pathophysiological conditions associated with vascular endothelial dysfunction and characterized by impairment of NO production, such as heart failure, hypertension, hypercholesterolemia, atherosclerosis, and diabetes.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: May 18, 2010
    Assignee: University of South Florida
    Inventors: Duane C. Eichler, Larry P. Solomonson, Laura C. Pendleton