Patents by Inventor Laura Cancedda

Laura Cancedda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR REDUCING THE EXPRESSION OF NKCC1 IN A SUBJECT
    Publication number: 20220380807
    Abstract: The invention relates to an RNA interference (RNAi) strategy based on the use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, the invention relates to a vector that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.
    Type: Application
    Filed: July 11, 2022
    Publication date: December 1, 2022
    Inventors: Federico Mingozzi, Giuseppe Ronzitti, Andrea Contestabile, Laura Cancedda
  • Method for reducing the expression of NKCC1 in a subject
    Patent number: 11427836
    Abstract: An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: August 30, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITE D'EVRY-VAL-D'ESSONNE, GENETHON, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, FONDAZIONE TELETHON
    Inventors: Federico Mingozzi, Giuseppe Ronzitti, Andrea Contestabile, Laura Cancedda
  • MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION
    Publication number: 20220184008
    Abstract: The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 16, 2022
    Inventors: Laura Cancedda, Marco De Vivo, Andrea Contestabile, Marco Borgogno, Annalisa Savardi, Jose Antonio Ortega Martinez
  • METHOD FOR REDUCING THE EXPRESSION OF NKCC1 IN A SUBJECT
    Publication number: 20210130847
    Abstract: An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.
    Type: Application
    Filed: April 11, 2018
    Publication date: May 6, 2021
    Inventors: Federico Mingozzi, Giuseppe Ronzitti, Andrea Contestabile, Laura Cancedda
  • Modulators of intracellular chloride concentration for treating down syndrome
    Patent number: 9822368
    Abstract: Modulators of intracellular chloride concentration for treating down syndrome The present invention relates to a modulator of a chloride transporter for use in the treatment of Down syndrome.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: November 21, 2017
    Assignees: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, B&A THERAPEUTICS
    Inventors: Laura Cancedda, Yehezkel Ben-Ari, Andrea Constestabile
  • Modulators of Intracellular Chloride Concentration for Treating Down Syndrome
    Publication number: 20160312229
    Abstract: Modulators of intracellular chloride concentration for treating down syndrome The present invention relates to a modulator of a chloride transporter for use in the treatment of Down syndrome.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Applicants: Fondazione Istituto Italiano di Tecnologia, B & A Therapeutics
    Inventors: Laura Cancedda, Yehezkel Ben-Ari, Andrea Constestabile
  • ELECTROPORATION DEVICES
    Publication number: 20140066836
    Abstract: Electroporation devices are provided which include a forceps-type member carrying first and second electrodes and a grip member carrying a third electrode. The third electrode is independently movable with respect to the first and second electrodes in order to vary the spatial configuration of the electrical field generated by the device and thus enable an improved range of action and efficacy. Methods for carrying out electroporation with such devices are also provided.
    Type: Application
    Filed: May 10, 2012
    Publication date: March 6, 2014
    Applicants: Consiglio Nazionale delle Ricerche, Fondazione Istituto Italiano di Tecnologia
    Inventors: Laura Cancedda, Gian Michele Ratto