Patents by Inventor Laura Cook Blumberg

Laura Cook Blumberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
    Patent number: 9585965
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: March 7, 2017
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • Prodrugs of heteraromatic compounds
    Patent number: 9580417
    Abstract: The present invention relates to prodrugs of parent drug compounds containing heteroaromatic NH groups.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: February 28, 2017
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, Orn Almarsson
  • Prodrugs of NH-Acidic Compounds
    Publication number: 20170015659
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Application
    Filed: August 3, 2016
    Publication date: January 19, 2017
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • PERIPHERALLY ACTING OPIOID COMPOUNDS
    Publication number: 20170007609
    Abstract: The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof:
    Type: Application
    Filed: July 12, 2016
    Publication date: January 12, 2017
    Inventors: Laura Cook Blumberg, Derrick Arnelle
  • MORPHAN AND MORPHINAN ANALOGUES, AND METHODS OF USE
    Publication number: 20160326119
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Application
    Filed: July 21, 2016
    Publication date: November 10, 2016
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Heterocyclic Compounds for the Treatment of Neurological and Psychological Disorders
    Publication number: 20160318869
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 3, 2016
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Peripherally acting opioid compounds
    Patent number: 9415045
    Abstract: The invention relates to a compound of Formula I, II, III, IV or a pharmaceutically acceptable ester or prodrug thereof:
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: August 16, 2016
    Assignee: Alkermes, Inc.
    Inventors: Laura Cook Blumberg, Derrick Arnelle
  • Morphan and morphinan analogues, and methods of use
    Patent number: 9416137
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: August 16, 2016
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman, Thomas Andrew Wynn
  • Process for Synthesizing Oxidized Lactam Compounds
    Publication number: 20160024012
    Abstract: The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
    Type: Application
    Filed: July 24, 2015
    Publication date: January 28, 2016
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Multi-API Loading Prodrugs
    Publication number: 20160024011
    Abstract: The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam-amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
    Type: Application
    Filed: May 4, 2015
    Publication date: January 28, 2016
    Inventors: Tarek A. Zeidan, Laura Cook Blumberg
  • Prodrugs of Heteraromatic Compounds
    Publication number: 20160009713
    Abstract: The present invention relates to prodrugs of parent drug compounds containing heteroaromatic NH groups.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 14, 2016
    Inventors: Laura Cook Blumberg, Orn Almarsson
  • Prodrugs of NH-Acidic Compounds
    Publication number: 20150376143
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Application
    Filed: June 30, 2015
    Publication date: December 31, 2015
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • MORPHAN AND MORPHINAN ANALOGUES, AND METHODS OF USE
    Publication number: 20150376197
    Abstract: The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Application
    Filed: August 24, 2015
    Publication date: December 31, 2015
    Inventors: Laura Cook Blumberg, Daniel R. Deaver, David J. Eyerman
  • Prodrugs of NH-Acidic Compounds: Ester, Carbonate, Carbamate and Phosphonate Derivatives
    Publication number: 20150320875
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Application
    Filed: May 22, 2015
    Publication date: November 12, 2015
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • Heterocyclic Compounds for the Treatment of Neurological and Psychological Disorders
    Publication number: 20150274670
    Abstract: Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
    Type: Application
    Filed: April 2, 2015
    Publication date: October 1, 2015
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Morphan and morphinan analogues, and methods of use
    Patent number: 9133125
    Abstract: The present application relates to analogs of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: September 15, 2015
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Laura Cook Blumberg, Dan Deaver, David Eyerman
  • Process for synthesizing oxidized lactam compounds
    Patent number: 9126936
    Abstract: The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 8, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Julius F. Remenar, Laura Cook Blumberg, Tarek A. Zeidan
  • Prodrugs of heteraromatic compounds
    Patent number: 9107911
    Abstract: The present invention relates to prodrugs of parent drug compounds containing heteroaromatic NH groups.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: August 18, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, Örn Almarsson
  • Prodrugs of NH-acidic compounds
    Patent number: 9102618
    Abstract: The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: August 11, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Laura Cook Blumberg, Julius F. Remenar, Orn Almarsson, Tarek A. Zeidan
  • Prodrugs of Secondary Amine Compounds
    Publication number: 20150210712
    Abstract: The present invention relates to compounds of Formula I:
    Type: Application
    Filed: February 3, 2015
    Publication date: July 30, 2015
    Inventors: Laura Cook Blumberg, John A. Lowe, III, Orn Almarsson, Juan Alvarez, Tarek A. Zeidan