Abstract: The invention relates to inhibitors of anaphase promoting complex/cyclosome (APC/C) function of formula (I), wherein the meaning for R1 and R2 is as disclosed in the description. These compounds are useful in the treatment of cancer, particularly, in the treatment of breast cancer.

Abstract: Methods, apparatus, and systems for analyzing user-activity data are disclosed. In one disclosed embodiment, for example, two or more data streams of low-level, user-activity data are detected at a computer workstation via two or more respective sensors. The two or more respective sensors may comprise a first sensor configured to detect network-access requests and a second sensor configured to detect at least one of the following events: file-activity events, window-title-change events, or user-interface events. Targeted user activity is identified from at least one of the data streams. The targeted user activity can comprise, for example, a user initiating a network access; performing a search on a search engine; creating, opening, or modifying a file; or initiating a network access that causes a window title to change.