Abstract: Example techniques for providing interactive exploration and analysis of cellular environments represented within multiplex immunofluorescence (MIF) images involve (i) obtaining a data graph representing a set of cells identified within image data for a cellular environment, wherein the data graph comprises (a) a set of nodes that each corresponds to a respective cell from the identified set of cells and (b) a set of node-to-node edges that each indicates a pairwise relationship between a respective pair of cells from the identified set of cells, (ii) for each respective node in at least a subset of the set of nodes, generating a node embedding corresponding to the respective node based on cellular information that is encoded by (a) the respective node and (b) one or more other nodes within a respective neighborhood of the respective node, and (iii) utilizing the generated node embeddings to facilitate evaluation of the cellular environment.

Abstract: Provided are methods and dosage regimens for treating cancer using an antibody that specifically binds to human DDR1 and an immune checkpoint inhibitor.

Abstract: Provided are methods and dosage regimens for treating cancer using an antibody that specifically binds to human DDR1.

Abstract: Provided herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for providing interactive exploration and analysis of cellular environments represented within MIF images. An embodiment includes a pipeline configured to generate an interactive visualization with selectable icons that represent cells in an MIF image by identifying identifying cells in the MIF image and generating a graph of the MIF image based on coordinates and the properties of the identified cells, with each node in the graph corresponding to the cells as well as neighboring cells. The graph may be transformed into embeddings and generating an interactive visualization of the graph based on the embeddings. Selectable icons in the interactive visualization correspond to nodes in the graph.

Abstract: Provided herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for providing interactive exploration and analysis of cellular environments represented within MIF images. An embodiment includes a pipeline configured to generate an interactive visualization with selectable icons that represent cells in an MIF image by identifying identifying cells in the MIF image and generating a graph of the MIF image based on coordinates and the properties of the identified cells, with each node in the graph corresponding to the cells as well as neighboring cells. The graph may be transformed into embeddings and generating an interactive visualization of the graph based on the embeddings. Selectable icons in the interactive visualization correspond to nodes in the graph.