Patents by Inventor Laura Dugan

Laura Dugan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydroethidine analogues and uses thereof
    Patent number: 9035057
    Abstract: Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: May 19, 2015
    Assignee: Washington University
    Inventors: Robert H. Mach, Mark Mintun, Wenhua Chu, Laura Dugan
  • DIHYDROETHIDINE ANALOGUES AND USES THEREOF
    Publication number: 20130079522
    Abstract: Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.
    Type: Application
    Filed: December 16, 2010
    Publication date: March 28, 2013
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Robert H. Mach, Mark Mintun, Wenhua Chu, Laura Dugan
  • Therapeutic Malonic Acid/Acetic Acid C60 Tri-Adducts of Buckminsterfullerene and Methods Related Thereto
    Publication number: 20070106087
    Abstract: Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adducts of buckminsterfullerene of the general formula C60R3, wherein each R is independently selected from groups of the formula ?CR1R2 wherein each R1 and R2 is independently selected from the group consisting of —H and —COOH, provided, however, that at least one of the R1's and R2's is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.
    Type: Application
    Filed: June 14, 2006
    Publication date: May 10, 2007
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Laura Dugan, Eva Lovett, Joshua Hardt, Kevin Quick
  • Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses
    Publication number: 20060116377
    Abstract: Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions, in particular stroke, Parkinson's disease, Alzheimer's disease. The compounds have not only low toxicity but also similar or superior LPO inhibition activity to references. They also effectively inhibit the cerebral neuronal cell death by ROS and/or zinc ion, and show neuroprotective effects against ischemic neuronal degeneration.
    Type: Application
    Filed: January 11, 2006
    Publication date: June 1, 2006
    Inventors: Eu-Gene Oh, Sung-Bo Ko, Kyung-Hwa Kim, In-Kyu Chang, Dennis Choi, Laura Dugan, Jae-Young Koh, In-Jae Shin, Moo-Ho Won
  • Method for treating neuronal injury with carboxyfullerene
    Patent number: 6265443
    Abstract: A method of treating neurotoxic injury, where the injury is the result of the release of oxygen-derived free radicals, is disclosed. The method utilizes carboxyfullerenes as free radicals scavengers to reduce the damage caused by the free radicals.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: July 24, 2001
    Assignee: Washington University
    Inventors: Dennis Wonkyu Choi, Laura Dugan, Tien-Sung Tom Lin, Tien-Yau Luh