Abstract: A method of (and concomitant computer software embodied on a non-transitory computer-readable medium for) generating speech comprising receiving a mel-frequency cepstrum employing a set of weighting functions, generating a pseudo-inverse of the set, reconstructing a speech waveform from the cepstrum and the pseudo-inverse, and outputting sound corresponding to the waveform. Also a corresponding method of (and concomitant computer software embodied on a non-transitory computer-readable medium for) encoding speech comprising receiving sounds comprising speech, computing mel-frequency cepstral coefficients from the sounds using a quantization method selected from the group consisting of non-uniform scalar quantization and vector quantization, and generating and storing codewords from the coefficients that permit recreation of the sounds.

Abstract: A speech enhancement method (and concomitant computer-readable medium comprising computer software encoded thereon) comprising receiving samples of a user's speech, determining mel-frequency cepstral coefficients of the samples, constructing a Gaussian mixture model of the coefficients, receiving speech from a noisy environment, determining mel-frequency cepstral coefficients of the noisy speech, estimating mel-frequency cepstral coefficients of clean speech from the mel-frequency cepstral coefficients of the noisy speech and from the Gaussian mixture model, and outputting a time-domain waveform of enhanced speech computed from the estimated mel-frequency cepstral coefficients.

Abstract: Quantitative object and spatial arrangement-level analysis of tissue are detailed using expert (pathologist) input to guide the classification process. A two-step method is disclosed for imaging tissue, by classifying one or more biological materials, e.g. nuclei, cytoplasm, and stroma, in the tissue into one or more identified classes on a pixel-by-pixel basis, and segmenting the identified classes to agglomerate one or more sets of identified pixels into segmented regions. Typically, the one or more biological materials comprises nuclear material, cytoplasm material, and stromal material. The method further allows a user to markup the image subsequent to the classification to re-classify said materials. The markup is performed via a graphic user interface to edit designated regions in the image.

Abstract: Quantitative object and spatial arrangement-level analysis of tissue are detailed using expert (pathologist) input to guide the classification process. A two-step method is disclosed for imaging tissue, by classifying one or more biological materials, e.g. nuclei, cytoplasm, and stroma, in the tissue into one or more identified classes on a pixel-by-pixel basis, and segmenting the identified classes to agglomerate one or more sets of identified pixels into segmented regions. Typically, the one or more biological materials comprises nuclear material, cytoplasm material, and stromal material. The method further allows a user to markup the image subsequent to the classification to re-classify said materials. The markup is performed via a graphic user interface to edit designated regions in the image.