Patents by Inventor Laura E. Fredenburgh

Laura E. Fredenburgh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of imidazolutidine
    Patent number: 5424432
    Abstract: This invention relates to a method for the preparation of a compound of formula I: ##STR1## a key intermediate in the synthesis of a series of Angiotensin II receptor antagonists. The invention also relates to a selective reagent for conducting the Hofmann rearrangement, particularly in the formation of a pyridinoimidazolone, which is a percursor to the formation of an imidazopyfidine of formula I. This invention also relates to a method for the preparation of imidazolutidine, a key intermediate in the synthesis of 3-(2'-(N-benzoyl)sulfonamidobiphen-4-yl)-methyl-5,7 -dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine, using pyridinoimidazolone, an unreactive urea.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: June 13, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Laura E. Fredenburgh, Robert D. Larsen, Ji Liu, Robert A. Reamer, Chris H. Senanayake, Thomas R. Verhoeven