Patents by Inventor Laura E. Niklason

Laura E. Niklason has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7498332
    Abstract: The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: March 3, 2009
    Assignee: Duke University
    Inventors: Laura E. Niklason, Andy McKee, Cecil Borel
  • Publication number: 20030235562
    Abstract: The present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering.
    Type: Application
    Filed: March 17, 2003
    Publication date: December 25, 2003
    Inventors: Laura E. Niklason, J. Andrew McKee, Christopher M. Counter
  • Patent number: 6537567
    Abstract: Improved methods for the production of tissue-engineered constructs, including muscular tissue constructs such as vascular constructs, are disclosed. The methods include the use of improved substrates for cell growth, improved cell culture media for cell growth, and the use of distensible bodies to impart pulsatile stretching force to lumens of constructs during growth. Also disclosed are improved products and methods for making those products, including substrates and cell culture media, for tissue engineering and tissue culture generally. Improved muscular tissue constructs, including vascular constructs, are also disclosed, which may be used in medicine for the repair or replacement of damaged natural structures. In an embodiment, a muscular, tubular tissue-engineered construct is prepared having a wall of mammalian smooth muscle cells oriented circumferentially about a lumen of the construct at a cell density of at least 107 cells/cc.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: March 25, 2003
    Assignee: Massachusetts Institute of Technology
    Inventors: Laura E. Niklason, Jinming Gao, Robert S. Langer
  • Publication number: 20020160001
    Abstract: The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage
    Type: Application
    Filed: February 14, 2002
    Publication date: October 31, 2002
    Inventors: Laura E. Niklason, Andy McKee, Cecil Borel
  • Patent number: 6443156
    Abstract: A separable double lumen endotracheal tube is disclosed having a first lumen and a second lumen and which are removably affixed together to allow the first lumen to be separated from the second lumen of the double lumen endotracheal tube and, if desired, to be subsequently affixed together again. Either lumen of the double lumen endotracheal tube can function alone for positive pressure ventilation, but normally the bronchial lumen will be removed from a patient and the tracheal lumen left in place to function alone to provide positive pressure ventilation as required by a patient. The double lumen endotracheal tube will, however, function to allow the bronchial lumen to remain in a patient subsequent to removal of the tracheal lumen as a matter of choice during a medical procedure.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: September 3, 2002
    Inventors: Laura E. Niklason, Loren T. Niklason
  • Patent number: 5872828
    Abstract: The invention includes both systems and methods for tomosynthesis x-ray imaging. An x-ray source is moved at various positions in an arc around an object, e.g., a breast, to illuminate a stationary digital detector (or its equivalent) placed at an image plane behind the object. A digital image data processor collects data from the detector and a motion controller moves the source around the object. As the source moves along the arc, the detector generates, for a succession of points along the arc, a corresponding succession of image data sets, each set being representative of the intensity of x-rays incident on the detector for the then current position of the source. The image data processor is responsive to the image data sets to generate an output image signal representative of the x-ray absorption of points within the object region.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: February 16, 1999
    Assignee: The General Hospital Corporation
    Inventors: Loren T. Niklason, Laura E. Niklason, Daniel B. Kopans