Patents by Inventor Laura EDGINGTON-MITCHELL

Laura EDGINGTON-MITCHELL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SULFOXONIUM YLIDE DERIVATIVES AS PROBES FOR CYSTEINE PROTEASE
    Publication number: 20230285598
    Abstract: The present invention relates to compounds of formula I bearing a sulfoxoniumylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 14, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Simon MOUNTFORD, Bethany M. ANDERSON, Monika SZABO, Luigi AURELIO, Philip THOMPSON
  • NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE
    Publication number: 20230140838
    Abstract: The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 4, 2023
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Bethany M. ANDERSON, Daniel P. POOLE, Luigi AURELIO, Paulina KASPERKIEWICZ, Marcin DRAG, Nigel BUNNETT
  • NOVEL ACTIVITY-BASED PROBES FOR NEUTROPHIL ELASTASE AND THEIR USE
    Publication number: 20220050107
    Abstract: The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 17, 2022
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Laura EDGINGTON-MITCHELL, Bethany M. ANDERSON, Daniel P. POOLE, Luigi AURELIO, Paulina KASPERKIEWICZ, Marcin DRAG, Nigel BUNNETT