Patents by Inventor Laura F. Silvian

Laura F. Silvian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of the crystal structure of Staphylococcus aureus isoleucyl-tRNA synthetase in antibiotic design
    Patent number: 6631329
    Abstract: The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase from Staphylococcus aureus, and the cognate tRNAile from Escherichia coli. The present invention further provides methods of using the atomic coordinates to identify and design new agents which modulate protein synthesis as well as the agents themselves.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: October 7, 2003
    Assignee: Yale University
    Inventors: Jimin Wang, Laura F. Silvian, Thomas A. Steitz