Abstract: Provided is method of treating a product of a chemical process, such as an amino acid or a nucleoside, the method comprising adding the product to a solvent such as propanol in a vessel to obtain a mixture, stirring the mixture, filtering the mixture so as to separate the product from the solvent and drying the filtered product.

Abstract: The present invention relates to the use of cannabinoids in the treatment of a neurodegenerative disease or disorder. In particular the cannabinoids cannabidiolic acid (CBDA) and cannabidivarin (CBDV) were able to produce neuroprotective effects in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with amyotrophic lateral sclerosis (ALS). Furthermore, the combination of the cannabinoid tetrahydrocannabinol (THC) with the drug olexisome provided a synergistic disease modifying effect in a mouse model of neurodegenerative disease. In particular these effects were associated with the symptoms associated with ALS.

Abstract: An embodiment of the invention relates to method for increasing HDL-C in a patient in need thereof. An embodiment of the invention relates to a method for decreasing high blood pressure. An embodiment relates to a treatment method for a patient with refractory type 2 diabetes to provide normal HbA1C glycemia.

Abstract: There is provided a pressure sensing device and related methods, the pressure sensing device comprising, a plurality of chambers for storing one or more visual indicators, wherein the plurality of chambers are configured to release the one or more visual indicators when a pressure exerted on the plurality of chambers exceeds one or more pressure thresholds. The plurality of chambers can be microchambers. The device may be used in conjunction with a bandaging system to indicate the pressure applied onto a site of treatment.

Abstract: A method is disclosed, involving converting at least one structured text document stored in a database into one or more vectors, training a machine learning model to associate the at least one vector with the editors for that structured text document, training a machine learning model to associate the at least one vector with the editors for that structured text document, receiving a second structured text document and converting said second structured text document into one or more vectors, then processing the one or more vectors of the unpublished structured text documents through the trained machine learning model to identify appropriate editor teams, before finally sending the unpublished structured text documents to a computer device associated with an editor.

Abstract: A genetically-modified bacterium, for example of the class Actinobacteria, and the use of such a bacterium in the bioconversion of a steroidal substrate into a steroidal product of interest. A method of converting a steroidal substrate into a steroidal product of interest, wherein the method comprises: inoculating culture medium with genetically-modified bacteria according to any of Claims 1 to 28 and growing the bacterial culture until a target OD600 is reached; adding a steroidal substrate to the bacterial culture when the target OD600 is reached; culturing the bacterial culture so that the steroidal substrate is converted to the steroidal product of interest; and extracting and/or purifying the steroidal product of interest from the bacterial culture.

Abstract: The present invention relates to a combination comprising cromoglicic acid or derivatives thereof and to dermatological compositions comprising said composition. The invention also relates to the use of said combination or composition for the treatment of dermatitis.

Abstract: A process for the preparation of graphene includes the steps of a) providing flash thermal treatment of a graphite oxide at a temperature up to 700° C. sufficient to produce exfoliation and under inert atmosphere and b) cooling the material obtained in the previous step below 90° C. The method further includes the step of c) heating the material resulting from the previous step under inert atmosphere at a temperature which is higher than the temperature of step a), wherein the heating rate is between 1 and 15° C./min. The graphenes obtained from the process exhibit excellent physico-chemical properties.

Abstract: The invention relates to a method and system for providing mobile based services for hotel PBX having an external number assigned which includes the steps of providing each hotel room which provides the mobile based service with at least one mobile station comprising a SIM, each SIM storing a different IMSI number; assigning a VPN to the hotel; assigning each IMSI number of each mobile station to a different MSISDN that can only be used internally in the MNO network and that cannot be dialed from other telephones; and assigning each MSISDN to a different extension number that can be used as a room extension number and that corresponds to the VPN number of the VPN of the hotel. The invention is advantageous in that it solves problems of prior art systems by making use of a mobile PBX, so that every hotel will have its own VPN numbers that can be used as room extensions.

Abstract: Methods of treating a wound, an ulcer and/or a burn responsive to inhibition of xanthine oxidoreductase to thereby reduce uric acid in an animal are provided wherein the methods include topical administration of a therapeutic agent effective for treatment of the wound, the ulcer and/or the burn wherein the therapeutic agent inhibits xanthine oxidoreductase to thereby reduce uric acid in the wound, ulcer and/or burn. Also provided are methods and kits for determining the severity of a wound, a burn and/or an ulcer including the step of detecting one or more of (i) a level of uric acid; (ii) a level of one or more uric acid precursors; and (iii) a presence, or absence of or level of xanthine oxidoreductase.

Abstract: The invention relates to a method and system for providing mobile based services for hotel PBX having an external number assigned which includes the steps of providing each hotel room which provides the mobile based service with at least one mobile station comprising a SIM, each SIM storing a different IMSI number; assigning a VPN to the hotel; assigning each IMSI number of each mobile station to a different MSISDN that can only be used internally in the MNO network and that cannot be dialed from other telephones; and assigning each MSISDN to a different extension number that can be used as a room extension number and that corresponds to the VPN number of the VPN of the hotel. The invention is advantageous in that it solves problems of prior art systems by making use of a mobile PBX, so that every hotel will have its own VPN numbers that can be used as room extensions.

Abstract: In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R1 is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention.