Abstract: An article of footwear having an upper and a sole structure includes a top midsole coupled to the upper, a sole plate coupled to the top midsole, and a front midsole coupled to the top midsole. The sole plate is disposed between the toe end and the widest section of the sole structure. A rear midsole is coupled to the top midsole and the sole plate and disposed between the heel end and the narrowest section of the sole structure. An outsole is directly coupled to the front midsole and the rear midsole. A toe end of the outsole extends beyond a toe end of the front midsole, and the toe end of the front midsole extends beyond a toe end of the sole plate. The toe ends of the sole plate, the front midsole, and the outsole extend beyond a toe end of the top midsole.

Abstract: An article of footwear that includes a sole structure and an upper and defines a widest section, a narrowest section, a toe end, a heel end, a lateral side, and a medial side. The sole structure includes a first midsole directly coupled to the upper that includes a lateral side depression and a medial side depression. The sole structure further includes a sole plate directly coupled to the first midsole, a second midsole directly coupled to the first midsole and the sole plate, and a third midsole directly coupled to the first midsole and the sole plate. A periphery of the third midsole defines a medial lip and a lateral lip. The lateral side depression of the first midsole receives the lateral lip of the third midsole, and the medial side depression of the first midsole receives the medial lip of the third midsole.

Abstract: An article of footwear having a sole structure and an upper and defining a widest section, a narrowest section, a toe end, a heel end, a lateral side, and a medial side. The sole structure includes a top midsole directly coupled to the upper, a sole plate directly coupled to the top midsole, a front midsole directly coupled to the top midsole and the sole plate, a rear midsole directly coupled to the top midsole and the sole plate, and an outsole directly coupled to the front midsole and the rear midsole. The top midsole includes an upper side and an underside, and the upper side of the top midsole includes a lip around an outer edge of the upper side. Further, the underside of the top midsole includes a plurality of recesses, and the top midsole includes an aperture that extends from the upper side to the underside.

Abstract: An article of footwear having a sole structure and an upper, the sole structure comprising a top midsole coupled to the upper, a sole plate coupled to the top midsole, a front midsole coupled to the top midsole and the sole plate, a rear midsole coupled to the top midsole and the sole plate, and an outsole coupled to the front midsole and the rear midsole. The front midsole is spaced forward from the rear midsole creating a cavity, and an underside of the sole plate is exposed in the cavity. The top midsole, the front midsole, and the rear midsole are made of a supercritical foam that includes an organic compound having an open-chain structure.

Abstract: An article of footwear having a sole structure and an upper, the sole structure comprising a widest section, a narrowest section, a toe end, a heel end, a lateral side, a medial side, a top midsole directly coupled to the upper, a sole plate directly coupled to the top midsole, a front midsole directly coupled to the top midsole and the sole plate between the toe end of the sole structure and the widest section of the sole structure, a rear midsole directly coupled to the top midsole and the sole plate between the heel end of the sole structure and the narrowest section of the sole structure, and an outsole directly coupled to the front midsole and the rear midsole. The front midsole is spaced forward from the rear midsole creating a void, and an underside of the sole plate is exposed in the void.

Abstract: A method for obtaining a genetically engineered leukocyte composition is provided. The method includes: (a) enriching a population of large cells from a biological sample obtained from a subject, wherein the biological sample comprises leukocytes without performing density gradient centrifugation; (b) contacting the population of large cells with an activating agent; and (c) transducing the population of large cells with a viral vector comprising a polynucleotide. The enriching comprises an array-based separation comprising a microfluidic device configured for deterministic lateral displacement comprising an array of obstacles, and the obstacles are elongated so that their length perpendicular to bulk fluid flow (P1) is longer than their width parallel to bulk fluid flow (P2) by at least 10%.

Abstract: An article of footwear having a sole structure and an upper, the sole structure comprising a top midsole coupled to the upper, a sole plate coupled to the top midsole, a front midsole coupled to the top midsole and the sole plate, a rear midsole coupled to the top midsole and the sole plate, and an outsole coupled to the front midsole and the rear midsole. The front midsole is spaced forward from the rear midsole creating a cavity, and an underside of the sole plate is exposed in the cavity. The top midsole, the front midsole, and the rear midsole are made of a supercritical foam that includes an organic compound having an open-chain structure.

Abstract: A sole plate for a sole structure of an article of footwear, the sole plate including a forefoot region including a toe end at the distal end of the forefoot region, a midfoot region, and a heel region including a heel end at the distal end of the heel region. The sole plate further including a medial side, a lateral side, a widest section, and a narrowest section. The sole plate defines an outer edge, and the outer edge includes a first plurality of peaks and a first plurality of valleys. The first plurality of peaks and the first plurality of valleys are located on the lateral side of the forefoot region, and the first plurality of peaks and the first plurality of valleys are disposed between the widest section of the sole plate and the toe end of the sole plate.

Abstract: An article of footwear having a sole structure and an upper, the sole structure comprising a widest section, a narrowest section, a toe end, a heel end, a lateral side, a medial side, a top midsole directly coupled to the upper, a sole plate directly coupled to the top midsole, a front midsole directly coupled to the top midsole and the sole plate between the toe end of the sole structure and the widest section of the sole structure, a rear midsole directly coupled to the top midsole and the sole plate between the heel end of the sole structure and the narrowest section of the sole structure, and an outsole directly coupled to the front midsole and the rear midsole. The front midsole is spaced forward from the rear midsole creating a void, and an underside of the sole plate is exposed in the void.

Abstract: An article of footwear having an upper and a sole structure includes a top midsole coupled to the upper, a sole plate coupled to the top midsole, and a front midsole coupled to the top midsole. The sole plate is disposed between the toe end and the widest section of the sole structure. A rear midsole is coupled to the top midsole and the sole plate and disposed between the heel end and the narrowest section of the sole structure. An outsole is directly coupled to the front midsole and the rear midsole. A toe end of the outsole extends beyond a toe end of the front midsole, and the toe end of the front midsole extends beyond a toe end of the sole plate. The toe ends of the sole plate, the front midsole, and the outsole extend beyond a toe end of the top midsole.

Abstract: Described herein are systems and methods for generating a product enriched in one or more target particles, comprising a cassette to which the one or more microfluidic cartridges are releasably coupled and supported, the cassette comprising (i) a plurality input containers releasably and fluidically coupled thereto, wherein at least one of the plurality of input containers comprises an incoming sample, (ii) a plurality of outlets having a plurality of output containers releasably and fluidically coupled thereto, (iii) one or more microfluidic cartridges for separating one or more target particles from the sample, and (iv) a plurality of fluidic channels extending between the plurality of inlets, the plurality of outlets, and the one or more microfluidic cartridges, wherein the cassette having the plurality of input containers, the plurality of output containers, and the one or more microfluidic cartridges coupled thereto, collectively provides a closed end-to-end sterile environment that enables inline contin

Abstract: Described herein are methods of producing enriched target cell populations that are susceptible to genetic engineering.

Abstract: Described herein are methods of producing enriched target cell populations that are susceptible to genetic engineering.

Abstract: Described herein are methods of producing enriched target cell populations that are susceptible to genetic engineering.

Abstract: Described herein are methods of producing enriched target cell populations that are susceptible to genetic engineering.