Abstract: A scope system is provided including an elongate tube with a distal portion and a lumen extending therethrough. The scope system also includes at least one accessory channel extending from a proximal end to a distal end and having with an accessory lumen extending therethrough, the at least one accessory channel movably disposed at least partially within the lumen of the elongate tube. The at least one accessory channel includes a distal section and a forward-viewing configuration and a side-viewing configuration. In the forward-viewing configuration, the distal section of the at least one accessory channel is substantially parallel to the distal portion of the elongate tube and in the side-viewing configuration, the distal section of the at least one accessory channel is arced at a radius greater than a radius of the distal portion of the elongate tube.

Abstract: The present invention provides compositions and methods of treating prostate cancer using a combination of a DNA vaccine, PD-1 inhibitor and an IDO inhibitor. Further, methods of measuring IDO activity as a way to identify a subpopulation of subjects with prostate cancer that may benefits from the treatment methods described herein are provided.

Abstract: The present disclosure provides modified immune cells or precursors thereof (e.g. T cells) comprising chimeric antigen receptors (CARs) capable of binding human IL13R?2. Also provided are bispecific CARs, parallel CARs, tandem CARs, BiTEs, BiTE/CARs, and BiTE/BiTEs. Compositions and methods of treatment are also provided.

Abstract: A watercraft deck cover system. The system provides a cover member. The cover member has fasteners placed along the perimeter of the cover member. A connector is on the top of the cover member and is designed to have a cord attached to the connector. The cord is secured to a frame at an overhead arm extending from the frame. When the fasteners are secured to a watercraft and connector is elevated by the cord, water is prevented from pooling on the deck of the watercraft.

Abstract: A scope system is provided including an elongate tube with a distal portion and a lumen extending therethrough. The scope system also includes at least one accessory channel extending from a proximal end to a distal end and having with an accessory lumen extending therethrough, the at least one accessory channel movably disposed at least partially within the lumen of the elongate tube. The at least one accessory channel includes a distal section and a forward-viewing configuration and a side-viewing configuration. In the forward-viewing configuration, the distal section of the at least one accessory channel is substantially parallel to the distal portion of the elongate tube and in the side-viewing configuration, the distal section of the at least one accessory channel is arced at a radius greater than a radius of the distal portion of the elongate tube.

Abstract: A system allows for rapid intraosseous delivery of fluids from a fluid reservoir via an intraosseous port having a tip disposed within the bone marrow of a patient. The system includes a housing with a chamber and a plunger. An actuator is moveable between first and second positions to move the plunger between the distal and proximal positions. A valve housing includes a first one-way valve fluidly coupled to the fluid reservoir, and a second one-way valve fluidly coupled to the intraosseous port. The valves of the valve housing are oriented such that movement of the actuator from the first to the second position moves the plunger from the distal to the proximal position, drawing fluid from the fluid reservoir through the first valve and into the chamber. Movement of the actuator from the second to the first position moves the plunger from the proximal to the distal position, driving fluid from the chamber through the port and second valve and through the intraosseous port.

Abstract: An apparatus and method is described for determining the location of a object inside a patient. Three dimensional image data of the patient is obtained by an imaging modality such as a C-arm X-ray device. The same or another imaging modality may be used to obtain projection radiographic images, having a coordinate system that can be registered with respect to that of the three dimensional image. The location of one or more features of a medical treatment device such as a needle or a catheter introduced into the imaging filed of view is determined either by an operator or by image analysis, in at least two projection radiographic images, and the position of the feature located in the three-dimensional volume. The projection on a radiographic image of a vector joining a first and a second position is used to assist in guiding the medical treatment device inside of the patient.

Abstract: A system and method for receiving services is presented. The system comprises a first splitter having an input, a first output and a slaved output receiving a first signal at the input having a single polarization including a first service and a slaved service, wherein the first signal is directed to the first output and the slaved output and selected by a first control signal applied at the input, a first tuner receiving the first output and tuning the first service and a slaved tuner receiving the slaved output and tuning the slaved service. The method comprises generating a first control signal to select a first signal, receiving a first signal including a first service and a slaved service, wherein the first service and the slaved service are at the same polarization, splitting the first signal with a first splitter to a first output and a first slaved output, tuning the first service from the first output with a first tuner and tuning the slaved service from the slaved output with a slaved tuner.

Abstract: An apparatus and method is described for determining the location of a object inside a patient. Three dimensional image data of the patient is obtained by an imaging modality such as a C-arm X-ray device. The same or another imaging modality may be used to obtain projection radiographic images, having a coordinate system that can be registered with respect to that of the three dimensional image. The location of one or more features of a medical treatment device such as a needle or a catheter introduced into the imaging filed of view is determined either by an operator or by image analysis, in at least two projection radiographic images, and the position of the feature located in the three-dimensional volume. The projection on a radiographic image of a vector joining a first and a second position is used to assist in guiding the medical treatment device inside of the patient.

Abstract: A system and method for administering the grant accountability process in which decisions are informed by objective indicators that are scaleable to the community, foundation and grantee levels. Indicator data is entered into a grant management database and objectively analyzed to inform future grant making decisions. Drillable gauges provide a visual representation of the status of each indicator. The gauges are organized into community, foundation and grantee levels to provide a snapshot of the community as a whole, the foundation, and each grantee as in various leadership agenda and priority areas.

Abstract: A system and method for receiving services is presented. The system comprises a first splitter having an input, a first output and a slaved output receiving a first signal at the input having a single polarization including a first service and a slaved service, wherein the first signal is directed to the first output and the slaved output and selected by a first control signal applied at the input, a first tuner receiving the first output and tuning the first service and a slaved tuner receiving the slaved output and tuning the slaved service. The method comprises generating a first control signal to select a first signal, receiving a first signal including a first service and a slaved service, wherein the first service and the slaved service are at the same polarization, splitting the first signal with a first splitter to a first output and a first slaved output, tuning the first service from the first output with a first tuner and tuning the slaved service from the slaved output with a slaved tuner.

Abstract: Application software is visually programmed with a relational diagram that is structured in a left-to-right format. Parts/beans of a software application are placed onto the relational diagram to illustrate an inherent visual flow of the application's logic. The relational diagram is further structured by providing a three column workspace for display of the parts/beans of the software application. The three column workspace can be further structured with a center column for placement of a main part/bean. A left most column is also provided for placement of others of the parts/beans which provide input to the main part/bean in the center column. In addition, a right most column is provided for placement of other parts/beans which receive output from the main part/bean in the center column. The application logic can be modified when a user adds at least one of the parts/beans directly to any one of the three columns in the workspace.