Patents by Inventor Laura Kaye
Laura Kaye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210369837Abstract: The present disclosure provides formulations and therapies for treating subjects with elevated levels of TIM-3 using gene-based cytotoxic immunostimulant therapy alone or with other immunotherapies.Type: ApplicationFiled: September 26, 2017Publication date: December 2, 2021Applicant: CANDEL THERAPEUTICS, INC.Inventors: Estuardo Aguilar-Cordova, Laura Kaye Aguilar, Antonio E. Chiocca, Brian Guzik, Sean Lawler, Maria Carmella Speranza
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Patent number: 9382272Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.Type: GrantFiled: January 22, 2010Date of Patent: July 5, 2016Assignee: Apotex Pharmachem Inc.Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
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Patent number: 9308334Abstract: An inhaler, the inhaler including a body (104) and a cartridge (106), the cartridge comprising a dose storage portion (122) and an airway (124), the dose storage portion being suitable for containing a plurality of doses of an inhalable medicament, the airway including a mouthpiece (128) at an end thereof, the inhaler device configured and arranged such that a dose of inhalable medicament from the dose storage portion can be accessed and arranged in a delivery configuration for delivery to a user through the airway upon inhalation through the mouthpiece by the user, the inhaler characterized in that the cartridge is replaceably removable from the body.Type: GrantFiled: September 28, 2011Date of Patent: April 12, 2016Assignee: Novartis AGInventors: Steven Dudley, John Palmer-Felgate, Sean Reynolds, Iain Breakwell, Jon Jamin, Steve Augustyn, Grant Smetham, Laura Kaye, John McGarva
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Patent number: 8563733Abstract: A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.Type: GrantFiled: August 12, 2010Date of Patent: October 22, 2013Assignee: Apotex Pharmachem IncInventors: Fan Wang, Laura Kaye Montemayor, Daqing Che, Stephen E. Horne
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Publication number: 20130206142Abstract: An inhaler, the inhaler including a body (104) and a cartridge (106), the cartridge comprising a dose storage portion (122) and an airway (124), 102 the dose storage portion being suitable for containing a plurality of doses of an inhalable medicament, the airway including a mouthpiece (128) at an end thereof, the inhaler device configured and arranged such that a dose of inhalable medicament from the dose storage portion can be accessed and arranged in a delivery configuration for delivery to a user through the airway upon inhalation through the mouthpiece by the user, the inhaler characterised in that the cartridge is replaceably removable from the body.Type: ApplicationFiled: September 28, 2011Publication date: August 15, 2013Applicant: NOVARTIS AGInventors: Steven Dudley, John Palmer-Felgate, Sean Reynolds, Iain Breakwell, Jon Jamin, Steve Augustyn, Grant Smetham, Laura Kaye, John McGarva
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Publication number: 20120065409Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.Type: ApplicationFiled: January 22, 2010Publication date: March 15, 2012Applicant: APOTEX PHARMACHEM INC.Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
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Publication number: 20100324298Abstract: A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.Type: ApplicationFiled: August 12, 2010Publication date: December 23, 2010Applicant: APOTEX PHARMACHEM INC.Inventors: Fan Wang, Laura Kaye Montemayor, Daqing Che, Stephen E. Horne
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Patent number: 7786309Abstract: A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.Type: GrantFiled: May 9, 2007Date of Patent: August 31, 2010Assignee: Apotex Pharmachem Inc.Inventors: Fan Wang, Laura Kaye Montemayor, Daqing Che, Stephen E. Horne
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Publication number: 20070287839Abstract: A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.Type: ApplicationFiled: May 9, 2007Publication date: December 13, 2007Inventors: Fan Wang, Laura Kaye Montemayor, Daqing Che, Stephen E. Home
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Patent number: 6932256Abstract: A pack for carrying school books and other items, with the weight substantially balanced between the front and back of the wearer. A yoke has front and back pouches, and an opening for the wearer's head. The sides of the front and back portions of the yoke are releasably connected by flaps at the sides of the back portion which engage a strip of hook-and-loop material on the front pouch. An auxiliary bag is detachably connected to the back pouch.Type: GrantFiled: April 9, 2003Date of Patent: August 23, 2005Inventors: Frederick G. Hale, Laura Kaye Blume
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Patent number: 6495691Abstract: A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I: or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl, alkoxycarbonyl, aryloxycarbonyl, nitrile, or carbamoyl of formula wherein R1 and R2 can be individually or simultaneously hydrogen, alkyl or part of a heterocyclic structure; Z can be hydrogen, halogen, alkyl, aryl, aryloxy or alkoxy group.Type: GrantFiled: July 11, 2001Date of Patent: December 17, 2002Assignee: Brantford Chemicals Inc.Inventors: Stephen E. Horne, Gamini Weeratunga, Bogdan M. Comanita, Jaipal Reddy Nagireddy, Laura Kaye McConachie