Patents by Inventor Laura Klimowski

Laura Klimowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070065909
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: February 9, 2006
    Publication date: March 22, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070020725
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: May 22, 2006
    Publication date: January 25, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
    Patent number: 6979556
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: December 27, 2005
    Assignee: Genentech, Inc.
    Inventors: Laura C. Simmons, Laura Klimowski, Dorothea Reilly, Daniel G. Yansura
  • Prokaryotically produced antibodies and use thereof
    Publication number: 20050170464
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20030073164
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: December 13, 2001
    Publication date: April 17, 2003
    Applicant: GENENTECH, INC.
    Inventors: Laura C. Simmons, Laura Klimowski, Dorothea Reilly, Daniel G. Yansura
  • Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof
    Patent number: 6489448
    Abstract: The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: December 3, 2002
    Assignee: Heska Corporation
    Inventors: Laura Klimowski, Cynthia Ann Tripp
  • Parasitic helminth larval thiol specific antioxidant proteins, nucleic acid molecules and uses thereof
    Patent number: 6031077
    Abstract: The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: February 29, 2000
    Assignee: Heska Corporation
    Inventors: Laura Klimowski, Cynthia Ann Tripp
  • Parasitic helminth larval thiol specific antioxidant proteins and nucleic acid molecules
    Patent number: 5744593
    Abstract: The present invention relates to parasitic helminth thiol specific antioxidant (TSA) larval proteins; to parasitic helminth larval TSA nucleic acid molecules, including those that encode such TSA proteins; to antibodies raised against such TSA proteins; and to compounds that inhibit parasitic helminth larval TSA activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: April 28, 1998
    Assignee: Heska Corporation
    Inventors: Laura Klimowski, Cynthia Ann Tripp