Patents by Inventor Laura ORIO

Laura ORIO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEAR-INFRARED CYANINE DYES AND CONJUGATES THEREOF
    Publication number: 20250084066
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: November 25, 2024
    Publication date: March 13, 2025
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
  • Near-infrared cyanine dyes and conjugates thereof
    Patent number: 12187708
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: January 7, 2025
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa
  • NEAR-INFRARED CYANINE DYES AND CONJUGATES THEREOF
    Publication number: 20240083880
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: November 10, 2023
    Publication date: March 14, 2024
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
  • Near-infrared cyanine dyes and conjugates thereof
    Patent number: 11851421
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: December 26, 2023
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa
  • NEAR-INFRARED CYANINE DYES AND CONJUGATES THEREOF
    Publication number: 20230312523
    Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: June 22, 2021
    Publication date: October 5, 2023
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
  • MANUFACTURING OF DIMERIC CONTRAST AGENTS
    Publication number: 20230303592
    Abstract: The invention relates to a process for the preparation of dimeric contrast agents for use in Magnetic resonance Imaging (MRI), in particular [?-[1-[bis[2-(hydroxy-kO)-3-[4,7,10-tris[(carboxy-kO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-kN1,kN4,kN7,kN10]propyl]amino]-1-deoxy-D-glucitolato(6-)]]di-gadolinium complex, which includes preparation steps carried out one-pot and without isolation of the obtained intermediate.
    Type: Application
    Filed: July 26, 2021
    Publication date: September 28, 2023
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Andrea BARALE, Valeria BOI, Aurelia FERRIGATO, Sonia GAZZETTO, Daniela GIARDINA-PAPA, Armando MORTILLARO, Laura ORIO, Massimo VERANI
  • MODIFIED CYANINE DYES AND CONJUGATES THEREOF
    Publication number: 20220242853
    Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 4, 2022
    Applicant: BRACCO IMAGING S.P.A.
    Inventors: Francesco BLASI, Chiara BRIOSCHI, Federica BUONSANTI, Luigi MIRAGOLI, Roberta NAPOLITANO, Laura ORIO, Lorena PIZZUTO, Giovanni VALBUSA
  • Synthesis of NIR fluorescent probe
    Patent number: 10870649
    Abstract: The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: December 22, 2020
    Assignee: BRACCO IMAGING SPA
    Inventors: Luciano Lattuada, Federica Buonsanti, Federico Crivellin, Fulvio Ferretti, Federico Maisano, Laura Orio, Lorena Pizzuto
  • IMPROVED SYNTHESIS OF NIR FLUORESCENT PROBE
    Publication number: 20200055855
    Abstract: The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
    Type: Application
    Filed: April 10, 2018
    Publication date: February 20, 2020
    Applicant: BRACCO IMAGING SPA
    Inventors: Luciano LATTUADA, Federica BUONSANTI, Federico CRIVELLIN, Fulvio FERRETTI, Federico MAISANO, Laura ORIO, Lorena PIZZUTO
  • COMPOSITIONS FOR THE PREVENTION AND/OR TREATMENT OF ALCOHOL USE DISORDERS
    Publication number: 20190365675
    Abstract: The invention relates to the use of acylethanolamides in the production of a medicinal product or nutraceutical for the prevention, relief, and/or treatment of alcohol use disorders in general, and of alcohol intoxication or pathological inebriation, and alcohol dependence syndrome in particular.
    Type: Application
    Filed: April 11, 2017
    Publication date: December 5, 2019
    Inventors: Laura ORÍO ORTIZ, Fernando RODRÍGUEZ DE FONSECA, María ANTÓN VALADÉS
  • 1,2,4-oxadiazole derivatives as drugs modulating the GLP-1 peptide receptor
    Patent number: 9050347
    Abstract: The present invention relates to the use of a compound of formula (I): or a pharmaceutically acceptable solvate or salt thereof in the preparation of a medicinal product for the prevention and/or the treatment of a disease in which the GLP-1 receptor participates or mediates, such as eating disorders or diseases, for example, obesity, anorexia, lipid dysfunction, diabetes, hyperinsulinism and cardiovascular diseases or metabolic syndrome.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: June 9, 2015
    Assignee: VIVIABIOTECH, S.L.
    Inventors: Fernando Antonio Rodríguez De Fonseca, Miguel Romero Cuevas, Laura Orio Ortíz, Juan Manuel Decara Del Olmo, Monica Alonso Scrignoli
  • 1,2,4-OXADIAZOLE DERIVATIVES AS DRUGS MODULATING THE GLP-1 PEPTIDE RECEPTOR
    Publication number: 20140031347
    Abstract: The present invention relates to the use of a compound of formula (I): or a pharmaceutically acceptable solvate or salt thereof in the preparation of a medicinal product for the prevention and/or the treatment of a disease in which the GLP-1 receptor participates or mediates, such as eating disorders or diseases, for example, obesity, anorexia, lipid dysfunction, diabetes, hyperinsulinism and cardiovascular diseases or metabolic syndrome.
    Type: Application
    Filed: January 25, 2011
    Publication date: January 30, 2014
    Applicant: VIVIABIOTECH, S.L.
    Inventors: Fernando Antonio Rodríguez De Fonseca, Miguel Romero Cuevas, Laura Orio Ortiz, Juan Manuel Decara Del Olmo, Monica Alonso