Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Abstract: A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Abstract: A system and device phase-aligns and sums signals from a very large array of sensors, such as microphones or ultrasonic transducers, without prior knowledge of time delays of signals reaching each sensor, so as to accommodate effects of reverberant fields or acoustic or ultrasonic media containing multiple reflectors or scatterers and/or having heterogeneous, unknown acoustic properties.

Abstract: A beamforming sensor node has an array of pressure wave sensors and beamforming circuitry. Each pressure wave sensor is configured within a unique processing channel including a time delay circuit for producing a signal, with a phase offset, representative of received pressure waves at said pressure wave sensor. The beamforming circuitry includes the time delay circuits for all processing channels and (a) sets the phase offset of each processing channel and (b) parallel processes all signals from the array of pressure wave sensors through respective time delay circuits to form a first coherent beam-formed signal from the node. A secondary beamforming node combines coherent beam-formed signals from the plurality of sensor nodes to produce a combined acoustic signal representative of received pressure waves at all sensor nodes.

Abstract: A noise canceling and communication system includes an in-ear device adapted to fit in the ear canal of a device user. A passive noise reduction element reduces external noise entering the ear canal. An external microphone senses an external acoustic signal outside the ear canal. An internal microphone senses an internal acoustic signal proximal to the tympanic membrane. One or more internal sound generators produce a noise cancellation signal and an acoustic communication signal, both directed towards the tympanic membrane. A probe tube shapes an acoustic response between the internal sound generator and the internal microphone to be relatively constant over a wide audio frequency band. An electronics module is located externally of the ear canal and in communication with the in-ear device for processing the microphone signals using a hybrid feed forward and feedback active noise reduction algorithm to produce the noise cancellation signal.

Abstract: A noise canceling and communication system is described. An in-ear device is adapted to fit in the ear canal of a device user. A passive noise reduction element reduces external noise entering the ear canal. An external microphone senses an external acoustic signal outside the ear canal to produce a representative external microphone signal. An internal microphone senses an internal acoustic signal proximal to the tympanic membrane to produce a representative internal microphone signal. One or more internal sound generators produce a noise cancellation signal and an acoustic communication signal, both directed towards the tympanic membrane. A probe tube shapes an acoustic response between the internal sound generator and the internal microphone to be relatively constant over a wide audio frequency band.