Patents by Inventor Laura Scaglia

Laura Scaglia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PURIFIED hCG
    Publication number: 20070299001
    Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained form the process is particularly high, amounting to about 25,000 IU/mg.
    Type: Application
    Filed: August 28, 2007
    Publication date: December 27, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gianfranco PARADISI, Mara Rossi, Laura Scaglia
  • Process of purification of hCG and recombinant hCG purified by that method
    Patent number: 7297777
    Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained form the process is particularly high, amounting to about 25,000 IU/mg.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: November 20, 2007
    Assignee: Laboratoires Serono SA
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Purified LH
    Patent number: 7053054
    Abstract: A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of the ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high, amounting to 25,000 IU/mg.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: May 30, 2006
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Purified LH
    Publication number: 20060079460
    Abstract: Recombinant human luteinizing hormone (LH) having a specific bioactivity of from 20,522 to 31,229 IU/mg and obtainable from a process for the purification of recombinant LH from a sample of crude recombinant LH in the supernatant of CHO cells which comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The recombinant LH can be formulated into a pharmaceutical composition and used for treating a fertility disorder.
    Type: Application
    Filed: November 28, 2005
    Publication date: April 13, 2006
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Purified lh
    Publication number: 20030186893
    Abstract: A process for the purification of recombinant human Luteinizing Hormone (LH) from a sample of crude recombinant LH in the supernatant of CHO cells comprises the combined use of the ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography and the reverse phase HPLC are performed twice and the final use of a gel permeation column allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified LH obtained from the process is particularly high, amounting to 25,000 IU/mg.
    Type: Application
    Filed: December 11, 2002
    Publication date: October 2, 2003
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia
  • Process of purification of hcg and recombinant hcg purified by that method
    Publication number: 20030104553
    Abstract: A process for the purification of recombinant human Chorionic Gonadotropin (hCG) from a sample of crude recombinant hCG in the supernatant of CHO cells comprises the combined use of ion-exchange chromatography and reverse phase HPLC. The ion-exchange chromatography is performed twice and the final use of a size exclusion chromatography allows the purification from any residual traces of contaminants. The specific bioactivity of the highly purified hCG obtained form the process is particularly high, amounting to about 25,000 IU/mg.
    Type: Application
    Filed: December 9, 2002
    Publication date: June 5, 2003
    Inventors: Gianfranco Paradisi, Mara Rossi, Laura Scaglia