Patents by Inventor Laura Simmons
Laura Simmons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9688775Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: GrantFiled: September 5, 2013Date of Patent: June 27, 2017Assignee: GENENTECH, INC.Inventors: Laura Simmons, Dana Andersen
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Publication number: 20140120580Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: September 5, 2013Publication date: May 1, 2014Applicant: GENENTECH, INC.Inventors: Laura SIMMONS, Dana ANDERSON
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Publication number: 20120077740Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.Type: ApplicationFiled: December 10, 2010Publication date: March 29, 2012Applicant: Genentech, Inc.Inventors: Avi J. Ashkenazi, Sarah Hymowitz, Robert F. Kelley, Iphigenia Koumenis, Woon-Lam Susan Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
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Publication number: 20110244517Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: February 23, 2011Publication date: October 6, 2011Inventors: Laura Simmons, Dana Andersen
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Patent number: 7855066Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.Type: GrantFiled: September 28, 2006Date of Patent: December 21, 2010Assignee: Genentech, Inc.Inventors: Avi J. Ashkenazi, Sarah Hymowitz, Robert F. Kelley, Iphigenia Koumenis, Woon-Lam Susan Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
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Patent number: 7575893Abstract: The present invention provides methods for producing humanized antibodies and increasing the yield of antibodies and/or antigen binding fragments when produced in cell culture. In one aspect of the invention, at least one framework region amino acid residue of the variable domain is substituted by a corresponding amino acid from a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequence of the variable domain. In another aspect, an amino acid is placed at a position proximal to a cys residue that participates in an intrachain variable domain disulfide bond that corresponds to an amino acid found at that position in a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequenc of the variable domain.Type: GrantFiled: January 23, 2004Date of Patent: August 18, 2009Assignee: Genentech, Inc.Inventor: Laura Simmons
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Publication number: 20080187966Abstract: The present invention provides methods for producing humanized antibodies and increasing the yield of antibodies and/or antigen binding fragments when produced in cell culture. In one aspect of the invention, at least one framework region amino acid residue of the variable domain is substituted by a corresponding amino acid from a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequence of the variable domain. In another aspect, an amino acid is placed at a position proximal to a cys residue that participates in an intrachain variable domain disulfide bond that corresponds to an amino acid found at that position in a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequence of the variable domain.Type: ApplicationFiled: October 30, 2007Publication date: August 7, 2008Applicant: Genentech, Inc.Inventor: Laura Simmons
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Publication number: 20070224664Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: January 25, 2007Publication date: September 27, 2007Applicant: GENENTECH, INC.Inventors: Laura Simmons, Dana Anderson
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Publication number: 20070161564Abstract: Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.Type: ApplicationFiled: November 22, 2006Publication date: July 12, 2007Applicant: Genentech, Inc.Inventors: Avi Ashkenazi, Sarah Hymowitz, Robert Kelley, Iphigenia Koumenis, Woon-Lam Leung, Mark O'Connell, Roger Pai, Zahra Shahrokh, Laura Simmons
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Publication number: 20070065909Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: February 9, 2006Publication date: March 22, 2007Applicant: GENENTECH, INC.Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
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Publication number: 20070020725Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: May 22, 2006Publication date: January 25, 2007Applicant: GENENTECH, INC.Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
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Publication number: 20070015244Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: May 22, 2006Publication date: January 18, 2007Applicant: GENENTECH, INC.Inventors: Laura Simmons, Dana Andersen
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Publication number: 20060246542Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: February 9, 2006Publication date: November 2, 2006Applicant: GENENTECH, INC.Inventors: Laura Simmons, Dana Andersen
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Publication number: 20060170728Abstract: According to one embodiment of the present invention, a service station for maintaining pens is provided. The service station includes a treadmill belt that has an outer surface and an inner surface. At least one wiper is positioned on the outer surface of the treadmill belt. The treadmill belt is mounted on a first roller and a second roller. The first roller and the second roller contact the inner surface of the treadmill belt for driving the treadmill belt. Either the first roller or the second roller can be coupled to a drive axle. Preferably, the drive axle is coupled to a paper motor via a paper drive shaft. The wiper can be, for example, a flicker squeegee or a wicking squeegee.Type: ApplicationFiled: March 27, 2006Publication date: August 3, 2006Inventors: Laura Simmons, Jonathan Andrews, Stephen Cooper
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Publication number: 20050170464Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: March 2, 2005Publication date: August 4, 2005Applicant: GENENTECH, INC.Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
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Publication number: 20040229310Abstract: The present invention provides methods for producing humanized antibodies and increasing the yield of antibodies and/or antigen binding fragments when produced in cell culture. In one aspect of the invention, at least one framework region amino acid residue of the variable domain is substituted by a corresponding amino acid from a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequence of the variable domain. In another aspect, an amino acid is placed at a position proximal to a cys residue that participates in an intrachain variable domain disulfide bond that corresponds to an amino acid found at that position in a variable domain consensus sequence subgroup that has the most sequence identity with the HVR1 and/or HVR2 amino acid sequenc of the variable domain.Type: ApplicationFiled: January 23, 2004Publication date: November 18, 2004Applicant: Genentech, Inc.Inventor: Laura Simmons
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Publication number: 20030077739Abstract: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment.Type: ApplicationFiled: August 26, 2002Publication date: April 24, 2003Applicant: GENENTECH, INC.Inventors: Laura Simmons, Dana Andersen