Patents by Inventor Laura Storoni

Laura Storoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NITRIC OXIDE RELEASING PHOSPHODIESTERASE TYPE 5 INHIBITOR
    Publication number: 20210322413
    Abstract: The invention relates to nitric oxide releasing phosphodiesterase type 5 (PDE5) inhibitors of formula (I) or (Ib) or (II) or a stereoisomer or a pharmaceutically acceptable salt thereof: useful for the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies. The invention further relates to 3-[(2S)-2,3-bis(nitrooxy)propoxy]propanoic acid and 6-(nitrooxy)hexanoic acid for use in the treatment of ocular condition associated with elevated intraocular pressure such as ocular hypertension, glaucoma or retinopathies.
    Type: Application
    Filed: July 31, 2019
    Publication date: October 21, 2021
    Inventors: Nicoletta ALMIRANTE, Stefania BRAMBILLA, Laura STORONI, Francesco IMPAGNATIELLO, Elena BASTIA
  • Combinations of prostaglandins and nitric oxide donors
    Patent number: 10610509
    Abstract: The present invention relates to compositions for treating glaucoma and elevated ocular pressure. The compositions comprise a nitric oxide releasing isomannide derivative and a prostaglandin F2? analog.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: April 7, 2020
    Assignee: NICOX S.A.
    Inventors: Nicoletta Almirante, Laura Storoni, Elena Bastia, Francesco Impagnatiello
  • Nitric oxide donating derivatives of fluprostenol
    Patent number: 10280138
    Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: May 7, 2019
    Assignee: NICOX S.A.
    Inventors: Nicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Francesco Impagnatiello
  • Nitric oxide donating carnosine compounds
    Patent number: 10093696
    Abstract: The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: October 9, 2018
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Nicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Sergio Romeo
  • Nitric oxide donating derivatives of latanoprost free acid
    Patent number: 10047047
    Abstract: The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: August 14, 2018
    Assignee: NICOX S.A.
    Inventors: Nicoletta Almirante, Laura Storoni, Elena Bastia, Stefania Brambilla, Francesco Impagnatiello
  • NITRIC OXIDE DONATING DERIVATIVES OF LATANOPROST FREE ACID
    Publication number: 20180118676
    Abstract: The present invention relates to 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxyderivatives of latanoprost and 15-nitrooxyderivatives of latanoprost free acid.
    Type: Application
    Filed: March 22, 2016
    Publication date: May 3, 2018
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Elena BASTIA, Stefania BRAMBILLA, Francesco IMPAGNATIELLO
  • NITRIC OXIDE DONATING DERIVATIVES OF FLUPROSTENOL
    Publication number: 20180118677
    Abstract: The present invention relates to 15-nitrooxyderivatives of fluprostenol, their use for the treatment of glaucoma and ocular hypertension and formulation containing 15-nitrooxy derivatives of fluprostenol.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 3, 2018
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Elena BASTIA, Stefania BRAMBILLA, Francesco IMPAGNATIELLO
  • Ophthalmic compositions containing a nitric oxide donor
    Patent number: 9895335
    Abstract: The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan-1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: February 20, 2018
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Ennio Ongini, Nicoletta Almirante, Laura Storoni, Elena Bastia
  • COMBINATIONS OF PROSTAGLANDINS AND NITRIC OXIDE DONORS
    Publication number: 20170354634
    Abstract: The present invention relates to compositions for treating glaucoma and elevated ocular pressure. The compositions comprise a nitric oxide releasing isomannide derivative and a prostaglandin F2? analog.
    Type: Application
    Filed: November 17, 2015
    Publication date: December 14, 2017
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Elena BASTIA, Francesco IMPAGNATIELLO
  • NITRIC OXIDE DONATING CARNOSINE COMPOUNDS
    Publication number: 20170291920
    Abstract: The present invention relates to nitric oxide donor carnosine derivatives having a great efficacy in reducing elevated intraocular pressure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Application
    Filed: September 2, 2015
    Publication date: October 12, 2017
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Elena BASTIA, Stefania BRAMBILLA, Sergio ROMEO
  • Quinone based nitric oxide donating compounds for ophthalmic use
    Patent number: 9598349
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Nicox Science Ireland
    Inventors: Nicoletta Almirante, Laura Storoni, Gael Ronsin, Elena Bastia
  • Quinone based nitric oxide donating compounds for ophthalmic use
    Patent number: 9446015
    Abstract: The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: September 20, 2016
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Ennio Ongini, Nicoletta Almirante, Laura Storoni
  • OPHTHALMIC COMPOSITIONS CONTAINING A NITRIC OXIDE DONOR
    Publication number: 20160158182
    Abstract: The present invention relates to compositions comprising a 4-nitrooxybutan-1-ol alkyl ester as nitric oxide donor. More specifically, the invention relates to compositions comprising 4-nitrooxybutan-1-ol alkyl ester as a nitric oxide donor and an ophthalmic drug, useful in controlling elevated intraocular pressure associated with glaucoma or ocular hypertension associated with other diseases or conditions. The invention is also directed to methods of controlling intraocular pressure utilizing said compositions.
    Type: Application
    Filed: July 7, 2014
    Publication date: June 9, 2016
    Inventors: Ennio ONGINI, Nicoletta ALMIRANTE, Laura STORONI, Elena BASTIA
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
    Publication number: 20160145192
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Application
    Filed: April 14, 2014
    Publication date: May 26, 2016
    Inventors: Nicoletta ALMIRANTE, Laura STORONI, Gael RONSIN, Elena BASTIA
  • Nitric oxide donor compounds
    Patent number: 9266820
    Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metabolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: February 23, 2016
    Assignee: Nicox Science Ireland
    Inventors: Nicoletta Almirante, Stefano Biondi, Ennio Ongini, Laura Storoni, Alessia Nicotra
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
    Publication number: 20150283106
    Abstract: The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
    Type: Application
    Filed: October 10, 2013
    Publication date: October 8, 2015
    Inventors: Ennio Ongini, Nicoletta Almirante, Laura Storoni
  • Quinone based nitric oxide donating compounds
    Patent number: 9079821
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: July 14, 2015
    Assignee: NICOX SCIENCE IRELAND
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • Quinone based nitric oxide donating compounds
    Patent number: 9061962
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: June 23, 2015
    Assignee: Nicox Science Ireland
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
    Publication number: 20140342998
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
    Type: Application
    Filed: October 23, 2012
    Publication date: November 20, 2014
    Applicant: NICOX S.A.
    Inventors: Gael Ronsin, Laura Storoni, Francesca Benedini
  • NITRIC OXIDE DONOR COMPOUNDS
    Publication number: 20140288142
    Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Inventors: Nicoletta ALMIRANTE, Stefano BIONDI, Ennio ONGINI, Laura STORONI, Alessia NICOTRA