Patents by Inventor Laura Tandeske

Laura Tandeske has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HCV multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof
    Patent number: 7871625
    Abstract: Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: January 18, 2011
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Chien, Doris Coit, Carlos George-Nascimento, Sansan Lin, Angelica Medina-Selby, Laura Tandeske
  • Hcv Multiple Epitope Fusion Antigens With Modified Proteolytic Cleavage Sites And Uses Thereof
    Publication number: 20080299544
    Abstract: Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.
    Type: Application
    Filed: August 26, 2005
    Publication date: December 4, 2008
    Inventors: David Y Chien, Doris Coit, Carlos George-Nascimento, Sansan Lin, Angelica Medina-Selby, Laura Tandeske
  • Polynucleotides encoding a multiple epitope fusion antigen for use in an HCV antigen/antibody combination assay
    Patent number: 7319144
    Abstract: The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: January 15, 2008
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Patent number: 7241879
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: July 10, 2007
    Assignee: Novartis Vaccines and Diagnostics, Inc.
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Publication number: 20040265801
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: July 26, 2004
    Publication date: December 30, 2004
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Multiple fusion antigens for use in immunoassays for anti-HCV antibodies
    Patent number: 6797809
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: September 28, 2004
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • HCV antigen/antibody combination assay
    Publication number: 20040096822
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 20, 2004
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Publication number: 20040063092
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: August 8, 2003
    Publication date: April 1, 2004
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Patent number: 6632601
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 14, 2003
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • HCV antigen/antibody combination assay
    Patent number: 6630298
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 7, 2003
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • HCV antigen/antibody combination assay
    Publication number: 20020192639
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Application
    Filed: June 14, 2001
    Publication date: December 19, 2002
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies
    Publication number: 20020146685
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: June 14, 2001
    Publication date: October 10, 2002
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby